Pyridoxine/Doxylamine: A Comprehensive Medication Guide

Summary or Key Points

Pyridoxine/doxylamine, commonly known as Diclegis, is a medication primarily used to manage nausea and vomiting in pregnancy. This guide will explain the usage, dosage, possible side effects, and other essential aspects of this medicine. It’s crucial to always consult your healthcare provider before making any changes to your medication regimen. Remember, you can immediately consult one of our providers through telemedicine.

Names of Medication

US Brand Name: Diclegis (Pyridoxine/doxylamine)

The ‘generic name’ (Pyridoxine/doxylamine here) refers to the active ingredients in the medication. It’s usually given in parentheses next to the brand name, which is the name the manufacturer gives to the drug.

Pharmacologic Category

Pyridoxine/doxylamine is categorized as an ‘Antiemetic’ medication. Other drugs in this category include Ondansetron, Prochlorperazine, and Metoclopramide.

Dosing

Pyridoxine/doxylamine is indicated for the treatment of the following condition in adults:

Nausea and Vomiting in Pregnancy

• Dose: Start with two tablets at bedtime on an empty stomach
• Frequency: If symptoms persist into the afternoon, the dose can be increased to one tablet in the morning and two tablets at bedtime
• Length of treatment: Continue as long as symptoms persist, and discontinue when no longer needed

Always consult your healthcare provider before adjusting your dose. Our telemedicine providers are available to help guide you.

Dosage Forms and Strengths

Pyridoxine/doxylamine is available in the following form and strength:

• Tablets: Pyridoxine (10mg) and Doxylamine (10mg)

Administration Instructions

Take Pyridoxine/doxylamine on an empty stomach with a glass of water. If you experience stomach upset, you may take it with food or milk. Do not crush, break, or chew the tablets; swallow them whole. If you miss a dose, take it as soon as you remember, but never double up to make up for a missed dose. Always consult with one of our telemedicine providers if you’re unsure.

Adverse Reactions and Side Effects

Like any medication, Pyridoxine/doxylamine can cause side effects. Not everyone will experience these, but if they occur, they may need medical attention. Common side effects include:

• Drowsiness: This is the most common side effect, affecting up to 14% of users. Avoid driving or operating heavy machinery until you know how this medication affects you.
• Dizziness: Up to 3.6% of users may experience this. Be careful when standing or sitting up quickly.
• Dry mouth: Affects around 1% of users. Drinking water, chewing gum, or sucking on hard candy can help.

Contraindications

A contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm it would cause the patient. Pyridoxine/doxylamine has the following contraindications:

• Allergic Reactions: Do not take this medication if you have a known allergy to pyridoxine, doxylamine, or any other components of the medication, as it could result in a severe allergic reaction.
• MAOI Therapy: If you are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI), you should avoid Pyridoxine/doxylamine. Combining these drugs can lead to serious side effects.

Drug to Drug Interactions

Some medications can interact with Pyridoxine/doxylamine, potentially altering its effectiveness or increasing side effects. Here are a few:

• Phenobarbital (Luminal)
• Phenytoin (Dilantin)
• Alcohol

Always consult your healthcare provider or one of our telemedicine professionals before starting any new medications.

Pyridoxine/doxylamine in Pregnancy

Yes, Pyridoxine/doxylamine is considered safe to use during pregnancy. It’s specifically designed to treat nausea and vomiting in pregnancy and is approved by the FDA for this use. Always consult your healthcare provider for personalized advice.

Pyridoxine/doxylamine while Breastfeeding

Pyridoxine/doxylamine is considered safe to use while breastfeeding. However, as all medicines can pass into breast milk, it’s always best to discuss this with your healthcare provider or one of our telemedicine professionals.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Pyridoxine/doxylamine, without insurance but with a GoodRX coupon, is approximately $140. Prices may vary depending on the pharmacy and your location.

Possible Alternatives

For nausea and vomiting in pregnancy, there are alternative treatments and lifestyle changes that might help:

• Alternative Medications: Medications such as Ondansetron (Zofran) can also be effective. Always consult with a healthcare provider before changing medications.
• Lifestyle Changes: Small, frequent meals, keeping crackers by your bed, ginger tea, and avoiding trigger smells can help manage symptoms. It’s essential to discuss these alternatives with a healthcare provider before making changes to your treatment plan.

Recent Updates on Pyridoxine/doxylamine Research

Recent studies continue to confirm the safety and efficacy of Pyridoxine/doxylamine for the treatment of nausea and vomiting in pregnancy. Some research suggests it may even be beneficial in the treatment of nausea and vomiting due to other medical conditions. Always consult one of our telemedicine professionals for the most up-to-date and personalized advice.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.