Ondansetron: What You Need To Know

Summary or Key Points

Ondansetron is a medication primarily used to prevent nausea and vomiting caused by certain medical conditions or treatments. It belongs to a class of drugs known as antiemetics. This article provides detailed information about its usage, dosage, potential side effects, and more. Always consult with a healthcare provider, like one of our telemedicine experts, before starting or adjusting the dose.

Names of Medication

US Brand Name: Zofran (Ondansetron)

The term ‘generic name’ refers to the official medical name of the drug that is universally recognized, regardless of the brand it’s sold under. In this article, the generic name is listed in parentheses after the brand name.

Pharmacologic Category

Ondansetron belongs to a class of medications called Serotonin 5-HT3 receptor antagonists. Other medications in this category include Granisetron, Palonosetron, and Dolasetron.

Dosing

For adults experiencing Nausea and Vomiting due to certain medical conditions or treatments, the usual dose of Ondansetron is 8 mg, taken 1 to 2 times daily. Treatment duration varies according to the nature and cause of symptoms. Always remember to consult your healthcare provider before adjusting your dose. If you need immediate consultation, our telemedicine providers are available to assist.

Dosage Forms and Strengths

• Tablets: 4 mg, 8 mg, and 24 mg
• Orally disintegrating tablets: 4 mg, 8 mg
• Oral solution: 4 mg/5 mL
• Injection: 2 mg/mL

Administration Instructions

Ondansetron can be taken with or without food. The tablets should be swallowed whole with water. For the orally disintegrating tablets, allow them to dissolve on the tongue and then swallow. Do not chew the tablet or film.

Adverse Reactions and Side Effects

Like all medications, Ondansetron may cause side effects. Not everyone will experience them, but if they occur, they may need medical attention. The most common side effects include:

• Headache (common)
• Constipation (common)
• Diarrhea (less common)
• Fatigue (less common)

If you experience any side effects, it is important to reach out to a healthcare provider immediately. You can consult with one of our telemedicine experts who are ready to provide immediate care.

Contraindications

A ‘contraindication’ is a specific situation in which a drug, procedure, or surgery should not be used because it may be harmful to the person. Ondansetron should not be used if you have:

• Severe liver disease: Ondansetron is metabolized in the liver, and its use can lead to an increase in liver enzyme levels in individuals with severe liver disease.
• Known allergy to Ondansetron or any of its components: An allergic reaction could lead to a severe, potentially life-threatening condition called anaphylaxis.

Drug to Drug Interactions

Interactions between Ondansetron and other drugs may alter how either medication works or increase the risk of adverse effects. Some medications that can interact with Ondansetron include:

• Apomorphine (Apokyn)
• Phenytoin (Dilantin)
• Rifampicin (Rifadin)
• Carbamazepine (Tegretol)

Ondansetron in Pregnancy

Ondansetron is considered a Pregnancy Category B drug by the FDA, which means that it should only be used during pregnancy if clearly needed. While some studies have shown no risk to the fetus, others suggest a possible link to certain birth defects. Always consult your healthcare provider before taking any medication during pregnancy.

Ondansetron while Breastfeeding

Ondansetron does pass into breast milk, but its effects on a nursing infant are unknown. As with all medications, consult your healthcare provider before using Ondansetron while breastfeeding.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Ondansetron, without insurance but using a GoodRx coupon, is approximately $10 for the 4mg dose.

Possible Alternatives

For Nausea and Vomiting, possible alternative treatments could include other antiemetic medications, such as Metoclopramide (Reglan) or Prochlorperazine (Compazine). Lifestyle changes, like eating small, frequent meals and staying well-hydrated, might also help. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are readily available for consultation.

Recent Updates on Ondansetron Research

As of now, ongoing studies are examining the long-term effects and safety of Ondansetron use in pregnancy, with some suggesting a potential link to certain birth defects. Other research is investigating its effectiveness in treating various other conditions like Irritable Bowel Syndrome (IBS). Please consult with your healthcare provider or one of our telemedicine experts for the most recent and relevant information.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.