Medication Profile: Encorafenib

Summary or Key Points

Encorafenib is a targeted cancer medication primarily used in the treatment of specific types of Melanoma and Metastatic Colorectal Cancer. It helps slow cancer growth and progression. This medication should be taken as directed by your healthcare provider. Side effects may occur, and close communication with your telemedicine provider will ensure the best possible outcome.

Names of Medication

US Brand Name: Braftovi (Encorafenib)

The generic name of a drug is its medical name, not linked to any specific brand. It’s the same active ingredient but may be manufactured by different companies. For this medication, the generic name is in parenthesis: Encorafenib.

Pharmacologic Category

Encorafenib belongs to the pharmacologic category known as Kinase Inhibitors.

Dosing

Encorafenib is used to treat the following diseases in adults:

• Melanoma: The usual dose is 450 mg once daily until disease progression or unacceptable toxicity. Consult your healthcare provider for any changes in the dose.
• Metastatic Colorectal Cancer: The usual dose is 300 mg once daily in combination with binimetinib until disease progression or unacceptable toxicity. Consult your healthcare provider before adjusting your dose. Remember, you can schedule a quick telemedicine consultation with our providers if you need assistance.

Dosage Forms and Strengths

Encorafenib (Braftovi) is available in the following forms and strengths:

• 50 mg tablets
• 75 mg tablets
• 100 mg tablets

Administration Instructions

Take Encorafenib exactly as your healthcare provider tells you. It should be taken orally once daily, with or without food. Do not change your dose or stop taking Encorafenib without first talking to your healthcare provider. If you have any questions, our telemedicine providers are readily available to assist you.

Adverse Reactions and Side Effects

While Encorafenib can be highly effective in treating certain types of cancer, it may also cause side effects. Not everyone experiences these side effects, but if they occur, they may need medical attention. Common side effects include:

• Fatigue: Feeling tired or weak (very common)
• Joint pain: Discomfort in joints (common)
• Abdominal pain: Discomfort or pain in the stomach area (common)
• Nausea: Feeling sick (common)
• Rash: Redness or irritation on the skin (common)

If you experience any side effects, please contact your healthcare provider promptly. If needed, schedule a consultation with one of our telemedicine providers for immediate assistance.

Contraindications

A contraindication refers to a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. For Encorafenib, the following are contraindications:

• Hypersensitivity to Encorafenib: If you are allergic to Encorafenib or any of its ingredients, this medication should not be taken due to the risk of a severe allergic reaction.

Drug to Drug Interactions

Some medications may interfere with the effectiveness of Encorafenib or cause adverse reactions. Always consult with your healthcare provider or one of our telemedicine practitioners if you’re taking other medications. Interacting medications include:

• Rifampin (Rifadin)
• Carbamazepine (Tegretol)
• Phenytoin (Dilantin)
• St. John’s Wort

Encorafenib in Pregnancy

Encorafenib is not recommended during pregnancy. It may harm an unborn baby. If you’re planning to become pregnant or are already pregnant, discuss this with your healthcare provider.

Encorafenib while Breastfeeding

It’s not known whether Encorafenib passes into breast milk. Therefore, breastfeeding is not recommended while taking this medication. Always consult your healthcare provider before making any decisions regarding breastfeeding while on Encorafenib.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Encorafenib, without insurance but using a GoodRx coupon, is approximately $13,000. It’s important to note that prices may vary based on location and pharmacy.

Possible Alternatives

While Encorafenib is often effective, alternative treatments may be suitable for some patients. However, always discuss these alternatives with your healthcare provider before making any changes to your treatment plan:

• Melanoma: Alternative treatments can include other targeted therapies, immunotherapies, radiation therapy, or surgical removal of the tumor. Lifestyle changes, like protecting your skin from the sun, can help prevent melanoma.
• Metastatic Colorectal Cancer: Other options can include chemotherapy, radiation therapy, surgery, or other targeted therapies. Healthy lifestyle choices, such as maintaining a balanced diet and regular exercise, may also be beneficial.

Recent Updates on Encorafenib Research

Recent research continues to support the use of Encorafenib for the treatment of certain cancers. In a study published in The Lancet Oncology, Encorafenib, in combination with other drugs, showed increased survival rates in patients with metastatic colorectal cancer. As always, it’s essential to discuss any questions or concerns with your healthcare provider. Our telemedicine team is readily available to assist you with any queries.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.