Binimetinib: Uses, Dosage, Side Effects & Cancer Treatment Guide

Key Points About Binimetinib

Binimetinib is a prescription medication used to treat certain cancers, including melanoma and other solid tumors. It works by blocking specific proteins that promote cancer cell growth. Typically, Binimetinib is used in combination with other cancer treatments. It’s essential to take Binimetinib exactly as prescribed and consult your healthcare provider before making any changes to your treatment plan. You can schedule a telemedicine appointment with one of our providers for personalized care.

Medication Names: Binimetinib and Its Brand

US Brand Name: Mektovi (Binimetinib)

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Binimetinib is the generic name, and Mektovi is the brand name.

Pharmacologic Category: MEK Inhibitor

Binimetinib belongs to a class of medications known as MEK inhibitors, a type of targeted cancer therapy. Other medications in this category include:

1. Trametinib (Mekinist)
2. Cobimetinib (Cotellic)

Binimetinib Dosage for Various Cancer Types

Binimetinib is used to treat several types of cancer. Below are the recommended doses for adults. Always consult your doctor or one of our telemedicine providers before adjusting your dose.

Binimetinib for Melanoma Treatment

Recommended Dose: 45 mg orally twice daily, in combination with encorafenib.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib Dosage for Non-Small Cell Lung Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib for Colorectal Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib Dosage for Thyroid Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib for Ovarian Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib Dosage for Pancreatic Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib for Breast Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib Dosage for Endometrial Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib for Gastric Cancer

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Binimetinib Dosage for Hepatocellular Carcinoma

Recommended Dose: 45 mg orally twice daily, in combination with other therapies.

Frequency: Twice daily.

Length of Treatment: Continue until disease progression or unacceptable toxicity.

Dosage Forms and Strengths of Binimetinib

Binimetinib is available in the following dosage form:

1. Tablet: 15 mg

How to Take Binimetinib: Administration Instructions

Take Binimetinib exactly as prescribed by your healthcare provider. It is typically taken twice a day, with or without food. Swallow the tablet whole with water. Do not crush, chew, or break the tablet. If you miss a dose, take it as soon as you remember, unless it’s close to your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you have any questions about how to take your medication, consult your doctor or schedule a telemedicine appointment with one of our providers.

Binimetinib Side Effects and Adverse Reactions

Like all medications, Binimetinib can cause side effects. Some are more common than others. It’s important to talk to your healthcare provider if you experience any side effects, especially if they are severe or persistent.

Common Binimetinib Side Effects (Affecting More Than 10% of Patients)

1. Fatigue: Feeling unusually tired or weak.
2. Nausea: Feeling sick to your stomach.
3. Diarrhea: Frequent, loose bowel movements.
4. Vomiting: Throwing up.
5. Abdominal Pain: Discomfort or pain in your stomach area.

Less Common Side Effects (Affecting 1-10% of Patients)

1. Rash: Red, itchy, or irritated skin.
2. Swelling: Fluid retention, especially in the hands, feet, or ankles.
3. Heart Problems: Changes in heart rhythm or heart failure.
4. Eye Problems: Blurred vision, sensitivity to light, or other vision changes.

Rare Side Effects (Affecting Less Than 1% of Patients)

1. Liver Damage: Yellowing of the skin or eyes, dark urine, or severe fatigue.
2. Blood Clots: Swelling, pain, or redness in the legs, or sudden shortness of breath.

If you experience any of these side effects, or have concerns about your treatment, contact your healthcare provider immediately. You can also schedule a telemedicine appointment with one of our providers for further guidance.

Contraindications for Binimetinib

A contraindication is a specific condition where a treatment or medication should not be used because it may cause harm. If you have any of the following conditions, Binimetinib may not be safe for you. Discuss your medical history with your healthcare provider before starting any new medication.

1. Heart Problems: Binimetinib can affect heart function, especially in patients with a history of heart failure or other heart conditions. It may cause or worsen heart failure, making it contraindicated in patients with significant heart disease.
2. Eye Disorders: Binimetinib can cause retinal detachment or other serious eye problems. If you have a history of eye conditions, especially retinal issues, this medication may not be safe for you.
3. Liver Disease: Since Binimetinib is processed by the liver, patients with moderate to severe liver impairment may not be able to safely metabolize the drug, leading to potential toxicity.
4. Bleeding Disorders: Binimetinib may increase the risk of bleeding, so it is contraindicated in patients with active bleeding disorders or those taking blood thinners.

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Drug to Drug Interactions

Binimetinib, a MEK inhibitor, can interact with other medications, potentially increasing side effects or reducing its effectiveness. It is crucial to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and supplements. Some known drug interactions include:

1. Warfarin (Coumadin): Binimetinib may increase the risk of bleeding when used with blood thinners like Warfarin.
2. Rifampin (Rifadin): This antibiotic can reduce the effectiveness of Binimetinib by accelerating its breakdown in the liver.
3. Carbamazepine (Tegretol): This seizure medication may also decrease Binimetinib’s effectiveness by speeding up its metabolism.
4. Ketoconazole (Nizoral): This antifungal drug can increase Binimetinib levels in the body, potentially leading to more pronounced side effects.
5. St. John’s Wort: This herbal supplement can reduce Binimetinib’s effectiveness by increasing its breakdown in the liver.

Binimetinib in Pregnancy

Is it Safe to Take Binimetinib During Pregnancy?

Binimetinib is not considered safe during pregnancy. Animal studies have shown that it can harm a developing fetus, increasing the risk of miscarriage or birth defects. If you are pregnant or planning to become pregnant, you should avoid taking Binimetinib. It is important to use effective contraception during treatment and for at least 30 days after your last dose. If you become pregnant while taking Binimetinib, contact your healthcare provider immediately to discuss your options.

Binimetinib While Breastfeeding

Is it Safe to Take Binimetinib While Breastfeeding?

It is not recommended to take Binimetinib while breastfeeding. Although there is no specific data on whether Binimetinib passes into breast milk, the potential for serious side effects in a nursing infant means breastfeeding should be avoided during treatment and for at least 3 days after your last dose. If you are breastfeeding or plan to breastfeed, talk to your healthcare provider about alternative options.

Estimated Cost of Binimetinib

The cost of Binimetinib can vary depending on your location and pharmacy. Without insurance, a 30-day supply is estimated to cost between $12,000 and $14,000. However, using a GoodRx coupon may help reduce this cost. Be sure to check with your pharmacy and explore financial assistance programs if needed.

Possible Alternatives to Binimetinib

If Binimetinib is not the right treatment for you, there are alternative therapies and lifestyle changes that may help manage your condition. Always discuss these options with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these alternatives.

1. Melanoma: Alternatives include immunotherapy (e.g., Pembrolizumab [Keytruda]), targeted therapies (e.g., Vemurafenib [Zelboraf]), or radiation therapy. Sun protection and regular skin checks are also essential.
2. Non-small cell lung cancer: Alternatives include chemotherapy (e.g., Cisplatin), immunotherapy (e.g., Nivolumab [Opdivo]), or targeted therapies (e.g., Osimertinib [Tagrisso]). Quitting smoking and maintaining a healthy lifestyle can improve outcomes.
3. Colorectal cancer: Alternatives include chemotherapy (e.g., FOLFOX regimen), immunotherapy, or targeted therapies (e.g., Cetuximab [Erbitux]). A fiber-rich diet and regular screenings are recommended for prevention and management.
4. Thyroid cancer: Alternatives include radioactive iodine therapy, surgery, or targeted therapies (e.g., Sorafenib [Nexavar]). Maintaining a healthy thyroid hormone balance through diet and medication may also help.
5. Ovarian cancer: Alternatives include chemotherapy (e.g., Paclitaxel), targeted therapies (e.g., Bevacizumab [Avastin]), or surgery. Maintaining a healthy weight and regular gynecological exams are important for prevention.
6. Pancreatic cancer: Alternatives include chemotherapy (e.g., Gemcitabine), radiation therapy, or surgery. A healthy diet and managing blood sugar levels may also help.
7. Breast cancer: Alternatives include hormone therapy (e.g., Tamoxifen), chemotherapy, or targeted therapies (e.g., Trastuzumab [Herceptin]). Regular mammograms and a healthy lifestyle are key to prevention and early detection.
8. Endometrial cancer: Alternatives include hormone therapy, radiation therapy, or surgery. Maintaining a healthy weight and managing hormone levels are important lifestyle factors.
9. Gastric cancer: Alternatives include chemotherapy (e.g., Capecitabine), targeted therapies (e.g., Ramucirumab [Cyramza]), or surgery. A healthy diet and regular screenings can help manage risk.
10. Hepatocellular carcinoma: Alternatives include targeted therapies (e.g., Sorafenib [Nexavar]), liver transplantation, or surgery. Avoiding alcohol and maintaining a healthy liver through diet and exercise are important lifestyle changes.

Recent Updates on Binimetinib Research

Recent studies continue to explore Binimetinib’s effectiveness in combination with other therapies for various cancers. Ongoing clinical trials are investigating its use with immunotherapies like Pembrolizumab (Keytruda) for melanoma and other cancers. Researchers are also studying its potential role in treating cancers such as colorectal and pancreatic cancer, where it may target specific genetic mutations. These studies are ongoing, and more data is needed to confirm the benefits of these combinations. If you are interested in participating in a clinical trial, speak with your healthcare provider or schedule a telemedicine appointment with one of our providers to discuss your options.

James Kingsley

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