Cobimetinib Medication Profile

Summary or Key Points

Cobimetinib is a targeted therapy medication used to treat certain types of melanoma in adults. As with all medications, it’s essential to understand the appropriate dosing, potential side effects, and the importance of proper administration. Always consult your healthcare provider, who is readily available through telemedicine, before making any changes to your medication regimen.

Names of Medication

US Brand Name: Cotellic (Cobimetinib)

In smaller sized text: The ‘generic name’ of a medication is its official medical name, whereas the ‘brand name’ is the commercial name given by the pharmaceutical company. In this case, Cotellic is the brand name, and Cobimetinib, indicated in parenthesis, is the generic name.

Pharmacologic Category

Cobimetinib belongs to a group of medications known as kinase inhibitors, specifically, MEK inhibitors. Other drugs in this category include trametinib and binimetinib.

Dosing

Melanoma: For adults with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, the recommended dose of Cobimetinib is 60 mg once daily for 21 days, followed by 7 days off treatment. This 28-day cycle is typically repeated until disease progression or unacceptable toxicity. Always consult with your healthcare provider, who can conveniently be reached via our telemedicine service, before making adjustments to your medication.

Dosage Forms and Strengths

Cobimetinib is available as a 20mg oral tablet.

Administration Instructions

Cobimetinib is taken orally, with or without food. If you miss a dose, do not take an extra dose to make up for the missed one. Instead, take your next dose as scheduled. If you vomit after taking Cobimetinib, do not take an additional dose. Instead, take your next dose as planned.

Adverse Reactions and Side Effects

Cobimetinib may cause side effects, the most common of which include:

• Diarrhea: Frequent loose or watery bowel movements. This happens in more than 60% of patients.
• Sensitivity to sunlight: Sunburn or rash can occur more easily. This happens in about 46% of patients.
• Nausea: A feeling of sickness with an inclination to vomit. This occurs in about 41% of patients.
• Vomiting: Involuntary emptying of stomach contents. This happens in about 35% of patients.

Always consult with your healthcare provider, available through our telemedicine service, if you experience any side effects. They can provide guidance on managing side effects and adjusting your treatment if necessary.

Contraindications

A contraindication refers to a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm it would cause the patient. Cobimetinib is contraindicated in patients who have had severe skin reactions following treatment with it or are allergic to cobimetinib or any of its ingredients. Allergy symptoms may include hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. Always consult with our healthcare provider, readily available through telemedicine, to understand if this medication is suitable for you.

Drug to Drug Interactions

Several drugs can interact with Cobimetinib, potentially affecting its efficacy or causing adverse reactions. Notable drugs include:

• Rifampin (Rifadin): This antibiotic can decrease the effectiveness of Cobimetinib.
• Ketoconazole (Nizoral): This antifungal medication can increase the blood levels and effects of Cobimetinib.

Always inform your healthcare provider, accessible via our telemedicine service, about all the medications you are currently taking, including over-the-counter products and dietary supplements.

Cobimetinib in Pregnancy

Cobimetinib can harm an unborn baby. Women should avoid getting pregnant while taking this medication and for some time after the last dose. If you are pregnant or planning to become pregnant, discuss this with your healthcare provider.

Cobimetinib while Breastfeeding

It’s not known whether Cobimetinib passes into breast milk. However, because of the potential for serious adverse reactions in nursing infants, women should not breastfeed during treatment and for some time after the final dose. Consult with your healthcare provider for more personalized advice.

Estimated Cost of Medication

The estimated cost for a 30-day supply of Cobimetinib is approximately $8,500 without insurance. However, using a GoodRx coupon, the cost may be reduced significantly. Always consult with your healthcare provider or pharmacist about ways to lower the cost of your medication.

Possible Alternatives

For melanoma, alternatives to Cobimetinib may include other targeted therapies or immunotherapies. Lifestyle changes, such as protecting your skin from the sun, may also help reduce the risk of melanoma. However, always discuss with your healthcare provider, accessible through our telemedicine service, before making any changes to your treatment plan.

Recent Updates on Cobimetinib Research

Recent studies continue to explore the efficacy and safety of Cobimetinib in various combinations and for different indications. A notable ongoing study is investigating the potential of Cobimetinib in combination with immunotherapy for advanced melanoma. This research aims to improve patient outcomes further and reduce side effects. As always, consult with your healthcare provider, available via our telemedicine, for the most recent and relevant information for your condition.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.