Sucralfate: An Informative Guide for Patients

Names of Medication

US Brand Name: Carafate (Sucralfate)

Pharmacologic Category

Sucralfate is classified as a gastroprotective agent, specifically a gastric mucosal protective agent.

Dosing

Sucralfate is used to treat the following diseases in adults:
Peptic ulcer disease
Stress ulcers
Gastric mucosal injury
Gastroesophageal reflux disease (GERD)
Remember to always consult with your healthcare provider before adjusting your medication dosage.

Peptic Ulcer Disease

The standard dosage for treating peptic ulcer disease is 1 gram of Sucralfate taken four times a day, usually taken one hour before meals and at bedtime. Treatment typically lasts for 4-8 weeks.

Stress Ulcers

For stress ulcers, the usual dose is 1 gram taken four times a day. The length of treatment varies depending on the patient’s individual needs and response to the medication.

Gastric Mucosal Injury

The typical dosage for gastric mucosal injury is 1 gram taken four times a day, with treatment duration dependent on the severity of the injury and the patient’s response to the medication.

Gastroesophageal Reflux Disease (GERD)

For GERD, the standard dosage is 1 gram taken twice a day. Treatment length varies based on the patient’s response and severity of symptoms.

Dosage Forms and Strengths

Sucralfate is available in the following forms and strengths:
Oral tablet: 1 gram
Oral suspension: 1 gram/10 mL

Administration Instructions

Sucralfate tablets should be taken on an empty stomach, typically one hour before meals and at bedtime. The oral suspension should be shaken well before use and can be taken with water to improve taste.

Adverse Reactions and Side Effects

Side effects and adverse reactions of Sucralfate may include:

Constipation (common)

Constipation is a common side effect of Sucralfate, occurring in up to 2-5% of patients. Sucralfate forms a protective barrier on the stomach lining, which can slow down gastrointestinal motility, leading to constipation. Increasing fluid and fiber intake may help alleviate this side effect.

Diarrhea (less common)

Diarrhea is a less common side effect of Sucralfate, affecting up to 1% of patients. The exact reason for diarrhea caused by Sucralfate is unknown, but it may be related to changes in gastrointestinal motility or the medication’s effect on the gastrointestinal lining.

Nausea and Vomiting (rare)

Nausea and vomiting are rare side effects of Sucralfate, occurring in less than 1% of patients. The exact cause is unknown but may be related to the medication’s effect on the stomach lining or gastrointestinal motility.

Dizziness and Headache (rare)

Dizziness and headache are rare side effects of Sucralfate, affecting less than 1% of patients. These side effects may be linked to the medication’s impact on the body’s hydration or electrolyte balance. Always report these side effects to your healthcare provider to rule out other possible causes.

Contraindications to Taking Sucralfate

A contraindication means that a certain drug or treatment is not advised due to potential harm or ineffectiveness. Sucralfate should not be used in the following situations:

Known Hypersensitivity to Sucralfate

Patients with a known hypersensitivity to Sucralfate or any of its ingredients should avoid taking this medication. Hypersensitivity reactions can result in a variety of symptoms, including rash, itching, swelling, severe dizziness, and difficulty breathing.

Severe Renal Impairment

Patients with severe renal impairment (kidney disease) should not use Sucralfate. This medication is eliminated by the kidneys and could accumulate in the body in patients with severe kidney disease, leading to increased risk of side effects.

Drug to Drug Interactions

Sucralfate may interact with the following medications:
Levothyroxine (Synthroid)
Ciprofloxacin (Cipro)
Tetracycline (Sumycin)
Phenytoin (Dilantin)
Digoxin (Lanoxin)
These interactions can reduce the absorption of these medications, decreasing their effectiveness. Always consult your healthcare provider or pharmacist before starting any new medications.

Sucralfate in Pregnancy

Sucralfate is classified as pregnancy category B. This means that studies in animals have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Therefore, Sucralfate should only be used during pregnancy if clearly needed and the potential benefits outweigh the potential risks.

Sucralfate while Breastfeeding

It’s currently unknown if Sucralfate passes into breast milk. However, due to its minimal absorption into the bloodstream, it’s unlikely to pose a significant risk to a nursing infant. Consult your healthcare provider before using this medication while breastfeeding.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Sucralfate, without insurance and using a GoodRx coupon, is approximately $30 to $60 for tablets and $80 to $120 for the suspension. Please note these are estimates, and prices may vary based on pharmacy, location, and any negotiated agreements between pharmacies and pharmaceutical manufacturers.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.