Medication Profile: Sirolimus

Summary or Key Points

Sirolimus, also known as Rapamune, is a medication primarily used to prevent organ rejection following transplantation. It is vital to follow dosing instructions and consult with your healthcare provider about any concerns. Potential side effects are present and need to be considered. Remember, you can contact our telemedicine providers for immediate consultation regarding Sirolimus.

Names of Medication

US Brand Name: Rapamune

Generic Name: Sirolimus (The generic name, denoted in parentheses, is the official medical name of the medication, not tied to any particular brand.)

Pharmacologic Category

Sirolimus falls under the category of immunosuppressant medications, alongside others like Tacrolimus and Cyclosporine.

Dosing

Sirolimus is indicated for the following condition in adults:

• Organ Transplant Rejection Prevention: The typical dosage is 2 mg once daily, following a loading dose of 6 mg. Treatment duration depends on the physician’s guidance. Always consult with your healthcare provider or our telemedicine team before changing your dose.

Dosage Forms and Strengths

Sirolimus is available as:

• Tablets: 1 mg, 2 mg
• Oral solution: 1 mg/mL

Administration Instructions

Sirolimus should be taken consistently either with or without food, but not with grapefruit products. It should be taken at the same time each day to maintain consistent blood levels. If you have trouble remembering your medication, consider setting a daily reminder.

Adverse Reactions and Side Effects

Sirolimus may cause a range of side effects. Not everyone will experience these, but if they occur, consult with your doctor or our telemedicine providers immediately:

• Common (occurring in >10% of patients): High cholesterol and triglycerides, high blood pressure, kidney problems, diarrhea, headache, joint pain
• Less Common: Rash, nausea, anemia, and edema (swelling)
• Rare: Allergic reactions, lung problems, lymphocele

Remember, if you notice any new or worsening symptoms while taking Sirolimus, contact your healthcare provider or consult with one of our telemedicine providers immediately.

Contraindications

Contraindications are specific situations in which a drug or treatment should not be used, because it may be harmful to the person. Sirolimus should not be used in the following cases:

• Allergy to sirolimus or its components: An allergic reaction can lead to severe complications.
• Liver disease: Sirolimus can further impair liver function.

Drug to Drug Interactions

Sirolimus can interact with other medications, including:

• Voriconazole (Vfend)
• Clarithromycin (Biaxin)
• Ketoconazole (Nizoral)

Always inform your healthcare provider or our telemedicine team about all the medications you are currently taking.

Sirolimus in Pregnancy

Sirolimus is not typically recommended during pregnancy due to potential risk to the developing fetus. Consult with your healthcare provider or our telemedicine team before starting sirolimus if you are pregnant or planning to become pregnant.

Sirolimus while Breastfeeding

Sirolimus can pass into breast milk, and may affect the baby. It is generally not recommended to breastfeed while taking sirolimus. Always discuss your options with your healthcare provider or our telemedicine team.

Estimated Cost of Medication

The estimated cost of a 30-day supply of sirolimus without insurance, using a GoodRX coupon, is approximately $300. Prices may vary depending on the pharmacy.

Possible Alternatives

For Organ Transplant Rejection Prevention, alternatives may include other immunosuppressants like Tacrolimus (Prograf) or Cyclosporine (Neoral). Lifestyle changes, such as maintaining a healthy diet and exercising regularly, can also contribute to overall health. However, always discuss these alternatives with your healthcare provider or our telemedicine team before making any changes to your treatment plan.

Recent Updates on Sirolimus Research

New research suggests that sirolimus might also have potential benefits in treating other diseases such as cancer and rare lung diseases due to its mTOR inhibitory effects. However, these studies are still ongoing, and the FDA has not approved sirolimus for these conditions yet. Remember, our telemedicine providers are here to help you understand the most recent developments in sirolimus research.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.