Medication Profile: Pertuzumab

Summary or Key Points

Pertuzumab is a targeted therapy used in the treatment of certain types of breast cancer, specifically, those which overexpress the HER2 protein. Its primary function is to prevent the HER2 protein from sending growth signals to the cancer cells. As with all medications, Pertuzumab has potential side effects and interactions, so it is vital to have detailed discussions with your healthcare provider, who you can conveniently consult via our telemedicine service.

Names of Medication

US Brand Name: Perjeta
Generic Name: Pertuzumab (In smaller font size)

A ‘generic name’ refers to the official medical name of the active ingredient in the medication. This is the name given in parenthesis.

Pharmacologic Category

• HER2/neu Receptor Antagonist
• Monoclonal Antibody

Dosing

Pertuzumab is indicated in adults for the treatment of HER2-positive breast cancer. It’s usually administered every three weeks in combination with Trastuzumab and Docetaxel. The initial dose is 840 mg over 60 minutes, followed by 420 mg over 30 to 60 minutes every three weeks thereafter. Always consult your doctor before adjusting your dose.

Dosage Forms and Strengths

• Pertuzumab is available in a single-dose vial containing 420 mg/14 mL (30 mg/mL) solution for intravenous infusion.

Administration Instructions

Pertuzumab is given as an intravenous infusion by a healthcare provider, usually once every three weeks. It should not be shaken or frozen, and any unused product should be discarded.

Adverse Reactions and Side Effects

Common side effects of Pertuzumab include diarrhea, hair loss, low white blood cell count, nausea, fatigue, rash, and peripheral neuropathy. Severe side effects may include heart problems, infusion-related reactions, and embryo-fetal toxicity. Each of these side effects varies in frequency and severity.

Contraindications

A ‘contraindication’ is a condition or factor that serves as a reason not to take a certain medicine due to the harm that it could cause the patient. Pertuzumab is contraindicated in patients with known hypersensitivity to Pertuzumab or to any of its excipients.

Drug to Drug Interactions

While Pertuzumab does not have any significant drug-to-drug interactions, it’s important to notify your healthcare provider about all medications you’re taking, including over-the-counter drugs and dietary supplements.

Pertuzumab in Pregnancy

Pertuzumab may cause harm to the fetus when administered to pregnant women. It is recommended to use effective contraception while taking Pertuzumab and for some time after the last dose.

Pertuzumab while Breastfeeding

It is not known if Pertuzumab is present in human breast milk, and potential harm to the infant cannot be ruled out. A decision should be made whether to discontinue breastfeeding or to discontinue Pertuzumab, considering the importance of the drug to the mother.

Estimated Cost of Medication

The cost of Pertuzumab can vary greatly depending on the patient’s insurance coverage. Without insurance, the estimated cost of a 30-day supply of Pertuzumab, using a GoodRx coupon, is approximately $5,874. Please note that the actual price may vary, and patients should check with their local pharmacy.

Possible Alternatives

Alternatives to Pertuzumab for the treatment of breast cancer may include other HER2 targeted therapies, such as Trastuzumab and Lapatinib, chemotherapy drugs, hormone therapies, and surgery. It’s also important to maintain a healthy lifestyle, including a balanced diet and regular exercise, as part of the overall treatment plan. Remember, these alternatives should only be considered after discussing them with your healthcare provider, who you can easily consult through our telemedicine services.

Recent Updates on Pertuzumab Research

Recent studies indicate that Pertuzumab, in combination with Trastuzumab and chemotherapy, significantly increases the overall survival rate in HER2-positive breast cancer patients. Researchers are also investigating its potential use in the treatment of other types of cancer. It is always crucial to remember that while research is ongoing, the current recommended use of Pertuzumab is for the treatment of specific types of breast cancer.

Being aware of the medications you take and understanding their effects on your body is an important part of managing your health. Please remember that you can consult one of our telemedicine providers anytime for any concerns or questions about your medication or condition.

This article does not replace professional medical advice and is intended for informational purposes only. Always consult with your healthcare provider for any medical concerns.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.