Ofatumumab Medication Profile

Summary or Key Points

Ofatumumab is an effective medication primarily used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis (MS). Known for its targeted action against the immune system’s B cells, this drug can manage these diseases by reducing harmful cell activities. However, side effects can occur, and it’s essential to follow administration guidelines for optimal benefits. Always consult a healthcare provider, such as our telemedicine team, to discuss your treatment options.

Names of Medication

US Brand Name: Kesimpta (Ofatumumab)

The ‘generic name’ refers to the active ingredient in the medication, which is usually named scientifically and remains the same across different brands. In this case, Ofatumumab is the generic name, provided in parenthesis.

Pharmacologic Category

Ofatumumab belongs to the class of medications known as monoclonal antibodies, specifically CD20-directed cytolytic antibodies.

Dosing

Ofatumumab is indicated to treat the following diseases in adults. Note that these are general dosages; the specific dose may vary depending on individual factors. Always consult a healthcare provider, available immediately via our telemedicine services, before adjusting your dose.

• Chronic Lymphocytic Leukemia: The standard dose is 300 mg on day 1, followed by 1,000 mg on day 2, and then 1,000 mg every 28 days for up to 12 cycles.
• Multiple Sclerosis: The initial dose is 20 mg, followed by 20 mg once a month for a total of 14 doses over a period of approximately 13 months.

Dosage Forms and Strengths

Ofatumumab is available in the following forms and strengths:

• Injection: 20 mg/0.4 mL single-dose prefilled syringe
• Injection: 20 mg/0.4 mL single-dose autoinjector

Administration Instructions

Ofatumumab is given by subcutaneous (under the skin) injection. It is typically administered by a healthcare provider, but some patients may be trained to self-administer the medication at home. Specific administration instructions depend on the patient’s health condition and the provider’s advice.

Adverse Reactions and Side Effects

While Ofatumumab effectively manages CLL and MS, side effects can occur. These include:

• Common side effects: Infections, tiredness, diarrhea, cough, headache, upper respiratory tract infection, and pain in extremities.
• Rare but severe side effects: Serious infections, infusion reactions, heart problems, kidney problems, and serious skin reactions.

If you experience any side effects, contact your healthcare provider immediately. Our telemedicine team is available for immediate consultations.

Contraindications

A ‘contraindication’ is a reason or condition that makes it unadvisable to take a particular medication due to the potential for harm or an adverse reaction. For Ofatumumab, contraindications include:

• Allergy to Ofatumumab or its components: Patients who have previously had an allergic reaction to Ofatumumab should avoid using it.
• Active Infection: Ofatumumab can weaken the immune system, making it harder for the body to fight off infections.

Always consult with a healthcare provider before taking any medication. Our telemedicine team can discuss your health history and determine if Ofatumumab is right for you.

Drug to Drug Interactions

Some medications may interact with Ofatumumab, altering its effectiveness or causing adverse effects. These include:

• Live vaccines: Interaction with Ofatumumab may increase your risk of infection from the vaccine.

Ofatumumab in Pregnancy

The safety of Ofatumumab during pregnancy is unclear. Animal studies have shown some risk, but there are no adequate studies in humans. If you’re pregnant or planning to become pregnant, discuss the potential risks and benefits with your healthcare provider. Our telemedicine team is readily available for consultations.

Ofatumumab while Breastfeeding

It’s currently unknown if Ofatumumab passes into breast milk. If you’re breastfeeding, consult with your healthcare provider to understand potential risks. Our telemedicine team can provide immediate consultations and guidance.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Ofatumumab, using a GoodRX coupon, is around $15,000. Prices can vary based on location and pharmacy. Remember, costs may be substantially lower with health insurance or patient assistance programs.

Possible Alternatives

There are alternatives to Ofatumumab, including other medications and lifestyle changes. It’s important to discuss these alternatives with a healthcare provider before making any changes to your treatment plan.

• Chronic Lymphocytic Leukemia: Alternative treatments include Rituximab (Rituxan), Alemtuzumab (Lemtrada), and lifestyle changes like a balanced diet and regular exercise.
• Multiple Sclerosis: Alternative treatments include Interferon beta-1a (Avonex, Rebif), Glatiramer acetate (Copaxone), and lifestyle changes such as stress management and regular physical activity.

Recent Updates on Ofatumumab Research

As of 2023, research is ongoing to explore the potential benefits of Ofatumumab in treating other autoimmune diseases. Recent studies have shown promising results in slowing disease progression in relapsing-remitting multiple sclerosis (RRMS) patients. As with all research, these findings need further validation. Stay connected with our telemedicine team for the most recent updates and to discuss how these findings may impact your treatment.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.