Nizatidine: A Comprehensive Guide for Patients

Names of Medication

US Brand Name: Axid (Nizatidine)

Pharmacologic Category

Nizatidine is a histamine H2-receptor antagonist. Other medications in this category include: Ranitidine (Zantac), Famotidine (Pepcid), Cimetidine (Tagamet)

Dosing

Nizatidine is used to treat the following diseases in adults:
Gastroesophageal reflux disease (GERD)
Peptic ulcer disease
Zollinger-Ellison syndrome
Erosive esophagitis
Nonerosive reflux disease

Dosing for these conditions may vary, so it’s important to consult with a healthcare professional before making any adjustments to your medication.

Gastroesophageal Reflux Disease (GERD)

The typical dose for treating GERD with Nizatidine is 150 mg twice daily or 300 mg once daily, usually for 8-12 weeks.

Peptic Ulcer Disease

For peptic ulcer disease, the recommended dose is 300 mg once daily at bedtime, typically for 4-8 weeks.

Zollinger-Ellison Syndrome

The dose for Zollinger-Ellison syndrome varies, starting at 150 mg twice daily, and may be increased under the supervision of a healthcare professional.

Erosive Esophagitis

For erosive esophagitis, the standard dose is 150 mg twice daily for up to 12 weeks.

Nonerosive Reflux Disease

In cases of nonerosive reflux disease, the typical dose is 150 mg twice daily for 4-8 weeks.

Always consult with a healthcare professional before making any changes to your medication or dosing.

Dosage Forms and Strengths

Nizatidine is available in the following forms and strengths:
Oral capsules: 150 mg and 300 mg
Oral solution: 15 mg/mL

Administration Instructions

Nizatidine can be taken with or without food. The capsules should be swallowed whole, and the oral solution should be measured with the provided measuring device for accurate dosing.

Adverse Reactions and Side Effects

Side effects of Nizatidine may include:

Headache (7-18%)

Headaches are a common side effect of Nizatidine. They may be caused by changes in blood flow or the release of histamine, which can trigger inflammation and pain in the head.

Dizziness (2-5%)

Dizziness may occur while taking Nizatidine due to its effect on the central nervous system. This side effect is usually mild and may resolve on its own.

Diarrhea (2-4%)

Diarrhea is another potential side effect of Nizatidine. It may result from changes in the gastrointestinal system caused by the medication.

Rash (1-2%)

Rashes can occur as a side effect of Nizatidine, likely due to an immune response to the medication. If the rash is severe or accompanied by other symptoms such as fever, seek medical attention immediately.

Contraindications to taking Nizatidine

A contraindication refers to a situation where a particular drug or treatment is not recommended due to the potential for harm or ineffectiveness. The following conditions are contraindicated for Nizatidine:

Allergy to Nizatidine or Similar Medications

If you have a known allergy to Nizatidine or similar medications such as ranitidine, famotidine, or cimetidine, you should not take Nizatidine. An allergic reaction could cause symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing.

Severe Kidney Disease

Nizatidine is excreted by the kidneys, so if you have severe kidney disease, your body may not be able to eliminate the drug effectively. This could lead to a buildup of the drug in your body, increasing the risk of side effects.

Drug to Drug Interactions

Nizatidine may interact with the following medications:
Ketoconazole (Nizoral)
Itraconazole (Sporanox)
Atazanavir (Reyataz)
Dasatinib (Sprycel)
Delavirdine (Rescriptor)

Nizatidine in Pregnancy

Nizatidine is classified as Pregnancy Category B by the FDA, which means that studies in animals have not shown a risk to the fetus, but there are no adequate studies in pregnant women. Always consult a healthcare provider before starting or continuing Nizatidine during pregnancy.

Nizatidine while Breastfeeding

Nizatidine is excreted into human milk in small amounts. While no adverse effects have been reported in breastfed infants, consult a healthcare provider before using Nizatidine while breastfeeding.

Estimated Cost of Medication

As of 2023, the estimated cost of a 30-day supply of Nizatidine 150 mg capsules, using a GoodRx coupon and without insurance, is approximately $25. Remember, prices may vary depending on the pharmacy, location, and any negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.