Nitroglycerin Ointment: Medication Guide

Summary or Key Points

Nitroglycerin ointment is a topical medication primarily used for managing angina (chest pain) and treating anal fissures. It helps relieve pain and promotes healing by relaxing the smooth muscles and dilating blood vessels. Always consult with your healthcare provider before starting or adjusting your dose. Immediate medical attention should be sought for severe reactions.

Names of Medication

Nitro-Bid (Nitroglycerin)

A ‘generic name’ is the standard name of the medicine, while the ‘brand name’ is the name given by the manufacturer. The generic name is listed in parentheses.

Pharmacologic Category

Nitroglycerin ointment falls under the category of Nitrates and Nitrites, along with Isosorbide Dinitrate (Isordil) and Isosorbide Mononitrate (Imdur).

Dosing

Nitroglycerin ointment is indicated to treat the following in adults:

• Anal Fissures: Apply a 1 inch (2.5 cm) strip of ointment, 0.2% to 0.4%, every 12 hours for up to 8 weeks.
• Raynaud’s Phenomenon: Apply as directed by your doctor.
• Chronic Anal Fissure: Apply a 1.5 cm strip of 0.2% ointment, three times a day for up to 8 weeks.

Always consult your healthcare provider before adjusting your dose.

Dosage Forms and Strengths

Nitroglycerin ointment is available in a 0.2% and 0.4% concentration in tubes of 30g and 60g.

Administration Instructions

Nitroglycerin ointment should be applied as directed by your healthcare provider. For anal fissures, it’s usually applied externally around the anal area. For angina, it is often applied on a specific area on the body such as the chest. Wash hands before and after use.

Adverse Reactions and Side Effects

Side effects of nitroglycerin ointment can include:

• Headache
• Lightheadedness
• Flushing of the face
• Allergic skin reactions

Contraindications

A contraindication is a condition that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Nitroglycerin ointment is contraindicated in patients who are allergic to nitroglycerin, and those using PDE-5 inhibitors (like sildenafil) due to a risk of severe hypotension.

Drug to Drug Interactions

Concomitant use of nitroglycerin with certain medications can result in adverse effects. Some of these medications include:

• Phosphodiesterase Type 5 (PDE5) inhibitors such as Viagra (sildenafil), Levitra (vardenafil), and Cialis (tadalafil)
• Riociguat (Adempas)
• Certain antihypertensive drugs

Nitroglycerin Ointment in Pregnancy

There’s limited data on the use of nitroglycerin ointment during pregnancy. Always consult your healthcare provider if you’re pregnant or plan to become pregnant while using this medication. Your provider can explain the potential risks and benefits to help make an informed decision.

Nitroglycerin Ointment while Breastfeeding

It’s not known whether nitroglycerin ointment can pass into breast milk. If you are breastfeeding, it’s important to discuss this with your healthcare provider before starting this medication.

Estimated Cost of Medication

The estimated cost of a 30-day supply of nitroglycerin ointment without insurance, using a GoodRX coupon, is approximately $30 – $60. However, prices can vary based on location, pharmacy, and other factors.

Possible Alternatives

While nitroglycerin ointment can be very effective, other treatments may be considered for the conditions listed above. These could include other medications, lifestyle changes, or surgical procedures. For example, high-fiber diets and adequate hydration can help prevent anal fissures. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan.

Recent Updates on Nitroglycerin Ointment Research

Recent research continues to explore the potential benefits of nitroglycerin ointment in various medical conditions. One study published in the British Journal of Surgery found that nitroglycerin ointment may reduce the need for surgery in patients with chronic anal fissure. However, more research is needed. Always consult your healthcare provider or our team of telemedicine experts for the most recent and relevant information.

Please note:
The information in this article is intended to be informational and should not be considered medical advice. Always consult your healthcare provider before starting any new medication or changing your current regimen. If you have any concerns or questions about nitroglycerin ointment, consider scheduling an appointment with one of our telemedicine providers today.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
While every effort has been made to ensure the accuracy of this information, medicine is a constantly evolving field, and changes may occur that may not be reflected here. Please discuss any concerns or questions you have about your health or medications with your healthcare provider.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.