Understanding Lubiprostone: A Comprehensive Guide

Names of Medication

In the United States, Lubiprostone is marketed under the brand name Amitiza.

Pharmacologic Category

Lubiprostone belongs to the pharmacologic category known as chloride channel activators. Other medications in this category include Linaclotide (Linzess).

Dosing

Lubiprostone is used to treat various diseases in adults. Dosages depend on the disease being treated and should always be determined by a healthcare professional. Never adjust your medication dosage without consulting with your healthcare provider first.

Chronic Idiopathic Constipation (CIC)

For Chronic Idiopathic Constipation (CIC), the standard dose is 24 mcg, taken orally twice daily.

Irritable Bowel Syndrome with Constipation (IBS-C)

For IBS-C, the typical dosage is 8 mcg, taken orally twice daily.

Opioid-induced Constipation (OIC)

For Opioid-induced Constipation (OIC), the recommended dosage is 24 mcg, taken orally twice daily.

Dosage Forms and Strengths

Lubiprostone comes in two strengths, 8 mcg and 24 mcg, in the form of soft gelatin capsules.

Administration Instructions

Lubiprostone should be taken orally with food and water to reduce the potential for nausea. The capsule should be swallowed whole and not crushed or chewed.

Adverse Reactions and Side Effects

As with all medications, Lubiprostone may cause side effects. The frequency of side effects varies, but some of the most common include:

Nausea (31%)

Nausea is the most common side effect of Lubiprostone. This medication increases intestinal fluid secretion, which may lead to feelings of nausea, especially when first starting the medication.

Diarrhea (12%)

As Lubiprostone works by increasing fluid in the intestines to help make bowel movements easier, it may sometimes lead to loose, watery stools or diarrhea.

Headache (11%)

Headaches are also a common side effect of many medications, including Lubiprostone. The exact reason is unclear, but it may be related to the body’s adjustment to the medication.

Contraindications to Taking Lubiprostone

A contraindication is a specific situation in which a drug, procedure, or surgery should not be used because it may be harmful to the patient. Lubiprostone is contraindicated in the following situations:

Known or suspected Mechanical Gastrointestinal Obstruction

Lubiprostone should not be used in patients with a known or suspected mechanical gastrointestinal obstruction. This medication works by increasing fluid in the intestines, which could lead to severe complications in the presence of an obstruction.

Drug to Drug Interactions

While Lubiprostone does not have any significant drug-drug interactions, it’s always crucial to inform your healthcare provider about all the medications you’re currently taking, including over-the-counter drugs and herbal supplements.

While Lubiprostone falls under pregnancy category C (which means risk cannot be ruled out), it should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Always consult with your healthcare provider for advice tailored to your circumstances.

Lubiprostone while Breastfeeding

It’s currently unknown if Lubiprostone passes into breast milk. It’s advisable to consult with your healthcare provider before using this medication while breastfeeding.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Lubiprostone (24 mcg twice daily) without insurance but with a GoodRx coupon is approximately $400-$450. Please remember these are only estimates and the prices may vary depending on pharmacy location and negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

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Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.