Linaclotide: An In-Depth Medication Guide

Names of Medication

In the United States, Linaclotide is marketed under the brand name Linzess.

Pharmacologic Category

Linaclotide belongs to a category of drugs known as guanylate cyclase-C (GC-C) agonists. This group also includes the medication Plecanatide (Trulance).

Dosing

Please remember to never adjust your dose of medication without consulting with your doctor first.

Irritable Bowel Syndrome with Constipation (IBS-C)

For the management of IBS-C in adults, the recommended dose of Linaclotide is 290 micrograms (mcg) taken orally once daily.

Chronic Idiopathic Constipation (CIC)

For adults suffering from CIC, the recommended dosage is 145 mcg taken orally once daily, although a dose of 72 mcg may also be considered based on patient need and tolerability.

Dosage Forms and Strengths

Linaclotide (Linzess) is available as capsules in three strengths: 72 mcg, 145 mcg, and 290 mcg.

Administration Instructions

Linaclotide should be taken on an empty stomach, at least 30 minutes before the first meal of the day. The capsule should be swallowed whole and should not be crushed or chewed.

Adverse Reactions and Side Effects

Diarrhea (common)

Diarrhea is a common side effect of Linaclotide and is a result of its mechanism of action, which increases the fluid in your intestines to help make bowel movements easier. It is most common when you first start taking the medication and usually decreases over time. However, if it becomes severe or persistent, contact your healthcare provider.

Abdominal pain or discomfort

Some people may experience stomach pain or discomfort when taking this medication.

Gas (flatulence)

Linaclotide can cause increased gas.

Bloating

Some people may feel bloated while taking this medication.

Abdominal distension

This refers to an increase in the size of the abdomen, possibly due to increased gas.

Viral gastroenteritis

This is an infection that can cause diarrhea, stomach pain, nausea, and vomiting.

Upper respiratory tract infection

Some people may experience symptoms such as a cough, sore throat, or runny nose.

Sinusitis

This is inflammation of the sinuses that can cause symptoms such as a runny or stuffy nose, headache, facial pain or pressure, and a reduced sense of smell and taste.

Increased liver enzymes

Some patients may show elevated liver enzymes on laboratory tests.

Contraindications

A contraindication is a specific situation in which a drug, procedure, or surgery should not be used, as it may be harmful to the patient. For Linaclotide, this includes:

Known or suspected mechanical gastrointestinal obstruction: Linaclotide should not be used in patients with known or suspected mechanical gastrointestinal obstruction.
Pediatric patients less than 6 years of age: Linaclotide is contraindicated in pediatric patients less than 6 years of age due to the risk of serious dehydration.
Pediatric patients 6 to less than 18 years of age: The safety and effectiveness of linaclotide have not been established in pediatric patients 6 to less than 18 years of age. It is generally not recommended for use in these patients.

Drug to Drug Interactions

Currently, there are no specific drugs listed that have significant interactions with Linaclotide. However, always inform your healthcare provider of all medications, supplements, and over-the-counter products you are using.

Linaclotide in Pregnancy

Linaclotide is classified as Pregnancy Category C, meaning there have been no adequate and well-controlled studies in pregnant women. Therefore, this medication should be used during pregnancy only if clearly needed and after a careful assessment of the risks and benefits.

Linaclotide while Breastfeeding

It is not known if Linaclotide is excreted in human milk. A decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Linaclotide without insurance, using a GoodRx coupon, can range from $370 to $400 for the 145 mcg dose. However, this is only an estimate, and the price may vary depending on the pharmacy, location, and any negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

Understanding Linaclotide: Key Takeaways

In summary, Linaclotide (Linzess) is a valuable medication used for the management of certain bowel conditions. As with any medication, it’s crucial to follow your healthcare provider’s instructions when taking Linaclotide. Be aware of potential side effects and contraindications, and consult your healthcare provider if you’re pregnant, breastfeeding, or considering either. Your healthcare provider can provide the most accurate and personalized advice based on your specific health circumstances.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.