Letrozole: A Comprehensive Medication Profile

Summary or Key Points

Letrozole, often recognized by the brand name Femara, is an oral medication used mainly to treat hormone-receptor-positive breast cancer in postmenopausal women. It operates as an aromatase inhibitor, effectively lowering estrogen levels in the body, thus inhibiting the growth of cancer cells. Regular consultation with your healthcare provider is essential for monitoring its effectiveness and managing potential side effects.

Names of Medication

US Brand Name: Femara
Generic Name: Letrozole

The ‘generic name’ refers to the active ingredient in the medication. In this case, Letrozole is the generic name and is presented in parentheses.

Pharmacologic Category

Letrozole is a part of the nonsteroidal aromatase inhibitors class of medications. Other medications in this category include Anastrozole (Arimidex) and Exemestane (Aromasin).

Dosing

Letrozole is primarily indicated for the treatment of hormone-receptor-positive breast cancer in postmenopausal women. The typical dosage is 2.5 mg, taken orally once daily. The duration of treatment is often extended based on clinical response and doctor’s advice. Always consult with your healthcare provider before adjusting your dosage.

Dosage Forms and Strengths

Letrozole is available as a tablet in the strength of 2.5 mg.

Administration Instructions

Letrozole is taken orally, with or without food. It is usually taken once a day at about the same time for better effectiveness. Always follow your healthcare provider’s instructions.

Adverse Reactions and Side Effects

Common side effects of Letrozole include hot flashes, fatigue, joint pain, and night sweats. Less common but more serious side effects can include osteoporosis, increased cholesterol levels, and cardiovascular disease. Contact your healthcare provider promptly if any of these side effects persist or worsen.

Contraindications

A contraindication is a condition or factor that suggests a medication should not be used because it could be harmful to the patient. Letrozole is contraindicated in pregnant women, those with hypersensitivity to Letrozole, and pre-menopausal women. This is due to the risk of fetal harm, potential allergic reactions, and the need for continued estrogen production in pre-menopausal women.

Drug to Drug Interactions

Letrozole may interact with hormone replacement therapy (HRT), products containing estrogen (like birth control pills Ethinyl Estradiol/Norgestimate – Ortho Tri-Cyclen), and tamoxifen (Nolvadex). Always inform your healthcare provider about any other medications you are taking.

Letrozole in Pregnancy

Letrozole is not recommended during pregnancy as it may harm the unborn baby or cause birth defects.

Letrozole while Breastfeeding

It is currently unknown whether Letrozole passes into breast milk. Due to potential risks to the nursing infant, Letrozole is not recommended while breastfeeding.

(Note: We have reached the halfway point in this medication profile. The following sections, including ‘Estimated Cost of Medication’, ‘Possible Alternatives’, ‘Recent Updates on Letrozole Research’, will be addressed in the second half of this profile. Thank you for your understanding.)

Estimated Cost of Medication

The estimated cost for a 30-day supply of Letrozole (2.5 mg), using a GoodRx coupon and without insurance, is typically around $10 to $15. However, costs can vary based on location and pharmacy. Always check current prices with your local pharmacy.

Possible Alternatives

For hormone-receptor-positive breast cancer, alternative treatments may include other aromatase inhibitors like Anastrozole (Arimidex), Exemestane (Aromasin), or hormonal therapies such as Tamoxifen. Additionally, lifestyle modifications, including a healthy diet and regular physical activity, may support overall health. Please discuss these alternatives with your healthcare provider before making any changes to your treatment plan.

Recent Updates on Letrozole Research

Recent studies indicate potential additional uses for Letrozole in fertility treatment, specifically in women with Polycystic Ovary Syndrome (PCOS). However, its use in such context should be under the strict guidance of a fertility specialist. Always stay informed about recent research and discuss any questions or concerns with your healthcare provider.

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Remember, this article is intended to provide a general overview of Letrozole and may not cover all potential drug interactions or adverse effects. This content is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider to discuss what is best for your individual health needs.

References and Further Reading

Please refer to the official FDA medication guide for Letrozole and professional drug reference resources for complete and updated information.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.