Medication Profile: Irinotecan

Summary or Key Points

Irinotecan is a powerful medication used in the treatment of certain types of cancers, specifically colon and rectal cancer. It works by interfering with cancer cell growth and reproduction, helping to slow the disease’s progression. Though effective, it carries a risk of side effects which should be carefully monitored. Always consult with a healthcare provider, like our telemedicine experts, for personalized advice and instruction on using this medication.

Names of Medication

US Brand Name: Camptosar (Irinotecan)

In medical terms, ‘generic name’ refers to the official, scientific name of a medication, while the brand name is the commercial title under which the medication is sold. The generic name is provided here in parenthesis.

Pharmacologic Category

Irinotecan belongs to the pharmacologic category of topoisomerase I inhibitors, alongside medications such as topotecan and belotecan.

Dosing

Note: The following information is a general guideline. For personalized dosing instructions, please consult your healthcare provider or one of our telemedicine experts.

• Colon Cancer: The typical dose of Irinotecan for treating colon cancer is 125 mg/m² given intravenously over 90 minutes, once weekly for four weeks followed by a two-week rest period. This six-week cycle is then repeated.
• Rectal Cancer: The dosage for rectal cancer is individualized based on the patient’s condition and response to therapy. It’s typically given in combination with other medications. Always consult your healthcare provider or our telemedicine experts for personalized dosing instructions.

Dosage Forms and Strengths

Irinotecan is available as an injection in two strengths: 40 mg/2 mL and 100 mg/5 mL single-dose vials.

Administration Instructions

Irinotecan is administered by intravenous infusion. It’s crucial to follow healthcare provider’s instructions regarding the timing and duration of infusion. Remember, our telemedicine team is always available to help answer your questions and guide you through this process.

Adverse Reactions and Side Effects

While Irinotecan can be effective in treating certain cancers, it may also cause some side effects. Not everyone will experience these, but if you do, it’s crucial to reach out to your healthcare provider or one of our telemedicine experts right away.

• Common (may affect up to 1 in 10 people): Diarrhea, nausea, vomiting, abdominal pain, fatigue, hair loss.
• Less common (may affect up to 1 in 100 people): Fever, changes in blood pressure, changes in heart rate, skin reactions.

If you notice any other side effects not listed here, please consult your healthcare provider or contact our telemedicine experts immediately.

Contraindications

A contraindication is a specific situation in which a drug, procedure, or surgery should not be used because it may be harmful to the patient. For Irinotecan, contraindications include:

• Allergic Reactions: Patients who have shown hypersensitivity to Irinotecan or any of its components should not use this medication, as it may trigger serious allergic reactions.
• Severe Liver Disease: Irinotecan is contraindicated in patients with severe liver disease, as the liver is responsible for metabolizing the drug, and impaired liver function may lead to toxicity.
• Pregnancy and Breastfeeding: Irinotecan is potentially harmful to a developing fetus and nursing child, so it’s contraindicated in these situations. More information on this is detailed below.

Before starting any new medication, it is essential to discuss any potential contraindications with your healthcare provider or one of our telemedicine experts.

Drug to Drug Interactions

Various medications can interact with Irinotecan, affecting how it works or increasing the risk of side effects. Examples of such drugs include:

• St. John’s Wort (Hypericum perforatum)
• Ketoconazole (Nizoral)
• Atazanavir (Reyataz)
• Rifampin (Rifadin, Rimactane)

Always inform your healthcare provider or consult with one of our telemedicine experts about all medications you’re currently taking, including over-the-counter drugs, prescription medications, and dietary supplements.

Irinotecan in Pregnancy

Due to potential harm to the developing fetus, Irinotecan is not recommended during pregnancy. If you are pregnant or planning to become pregnant, it is essential to discuss the potential risks and benefits with your healthcare provider or one of our telemedicine experts.

Irinotecan while Breastfeeding

Irinotecan is also not recommended while breastfeeding, as it can pass into breast milk and harm a nursing infant. Discuss with your healthcare provider or contact one of our telemedicine experts about safer treatment options during this period.

Estimated Cost of Medication

As of the time of this article, the estimated cost for a 30-day supply of Irinotecan using a GoodRX coupon is approximately $600, but costs can vary. Always check with your pharmacy for the most accurate and up-to-date pricing.

Possible Alternatives

Alternative treatments or lifestyle changes for colon and rectal cancer might include other chemotherapy drugs, radiation therapy, surgery, or targeted therapies. It’s important to discuss these alternatives with your healthcare provider or one of our telemedicine experts before making any changes to your treatment plan.

Recent Updates on Irinotecan Research

Research into Irinotecan is ongoing. Recent studies have shown promise in using Irinotecan in combination with other chemotherapy drugs for more effective treatment of certain cancers. Another area of active research is investigating genetic factors that may influence how individuals respond to the medication. Always discuss the latest treatment options and research findings with your healthcare provider or one of our telemedicine experts.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.