Medication Profile: Idelalisib

Summary or Key Points

Idelalisib is a crucial medication used to treat specific types of blood cancers. It belongs to the class of drugs known as kinase inhibitors, specifically targeting cells that contribute to the growth of cancer. This article will provide a comprehensive overview of Idelalisib, including its pharmacological category, dosing instructions, available dosage forms, administration directions, and potential side effects. Remember, this information is meant to support, not replace, a conversation with your healthcare provider. Our telemedicine professionals are readily available for a consultation.

Names of Medication

US Brand Name: Zydelig (Idelalisib)

The term ‘generic name’ refers to the official medical name of the active ingredient in the medication. This is the name used universally by healthcare professionals, regardless of the brand name under which it’s sold. In this article, the generic name of the medication is provided in parenthesis next to the brand name.

Pharmacologic Category

Idelalisib belongs to the pharmacological class of drugs known as PI3K inhibitors. Other drugs in this category include Copanlisib (Aliqopa) and Duvelisib (Copiktra).

Dosing

Idelalisib is indicated to treat the following conditions in adults:

• Chronic Lymphocytic Leukemia (CLL): The standard dose is 150 mg, taken orally twice daily until disease progression or unacceptable toxicity. Always consult your doctor before adjusting your dosage. If you’re experiencing any side effects or need to discuss your treatment, our telemedicine professionals are just a call away.
• Follicular Lymphoma (FL): The standard dose is 150 mg, administered orally twice daily until disease progression or unacceptable toxicity. Never change your medication dose without first discussing it with your healthcare provider. Our telemedicine service makes this easier than ever.
• Small Lymphocytic Lymphoma (SLL): The standard dosage is 150 mg, to be taken orally twice a day until disease progression or unacceptable toxicity. Always consult with your healthcare provider before adjusting your dose. We’re here for you via our telemedicine service for immediate consultation.

Dosage Forms and Strengths

Idelalisib is available in tablet form with the following strengths: 100 mg and 150 mg.

Administration Instructions

Idelalisib should be taken orally twice daily, with or without food. It is crucial to take it around the same time each day for the best effect. Do not crush or split the tablet. If you miss a dose, take it as soon as you remember, unless it is closer to the time of your next dose. Do not double up doses. Always consult your healthcare provider or one of our telemedicine professionals if you have any concerns or questions about taking this medication.

Adverse Reactions and Side Effects

While Idelalisib can be highly effective, it does carry the risk of certain side effects. Not everyone experiences these, but it’s important to be aware of them:

• Frequent: Diarrhea, fever, fatigue, nausea, cough, pneumonia, abdominal pain, chills, and rash.
• Less frequent

  but severe: Serious infections, decreased white blood cell count, liver problems, intestinal perforation, severe skin reactions, and allergic reactions.

If you experience any of these side effects or any other unexpected symptoms, immediately reach out to your healthcare provider or connect with our telemedicine professionals.

Contraindications

A contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it could cause the patient. For Idelalisib, contraindications include:

• Allergy to Idelalisib: Individuals who have shown hypersensitivity to Idelalisib should avoid the medication. The drug could provoke an allergic reaction, leading to symptoms such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
• Severe liver impairment: Idelalisib is metabolized in the liver. In cases of severe liver impairment, the body’s ability to process the drug is reduced, increasing the risk of adverse reactions.

Drug to Drug Interactions

Certain medications may interact with Idelalisib, potentially impacting its effectiveness or causing side effects. These include:

• Ketoconazole (Nizoral)
• Rifampin (Rifadin, Rimactane)
• Carbamazepine (Tegretol)
• St. John’s Wort (Hypericum perforatum)

Please inform your healthcare provider of all the medications you’re taking. If you’re uncertain about any potential interactions, our telemedicine providers are available for immediate consultation.

Idelalisib in Pregnancy

It is generally not recommended to take Idelalisib during pregnancy. Animal studies have shown potential harm to the fetus, and there is not enough data about its use in pregnant humans. Always consult with your healthcare provider if you’re pregnant or planning to become pregnant while taking this medication.

Idelalisib while Breastfeeding

It is not known whether Idelalisib passes into breast milk. Given its potential side effects, nursing mothers should discuss the risks and benefits with their healthcare provider. Our telemedicine professionals can provide immediate guidance on this issue.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Idelalisib, without insurance, using a GoodRX coupon is approximately $8,500. This can vary based on location and pharmacy.

Possible Alternatives

While Idelalisib is a powerful medication, other treatments or lifestyle changes might also be beneficial for patients with:

• Chronic Lymphocytic Leukemia: Alternatives include chemotherapy, monoclonal antibodies, or stem cell transplantation. Healthy lifestyle changes, such as maintaining a balanced diet and regular exercise, can support overall health.
• Follicular Lymphoma: Other treatments include radiation therapy, monoclonal antibody therapy, or chemotherapy. Healthy lifestyle changes can complement these treatments.
• Small Lymphocytic Lymphoma: Alternatives include targeted therapy, chemotherapy, and monoclonal antibody therapy. Always discuss these options with your healthcare provider. Our telemedicine professionals are available for immediate consultation.

Recent Updates on Idelalisib Research

Recent research has highlighted the efficacy of Idelalisib for relapsed or refractory Chronic Lymphocytic Leukemia. Studies indicate a high response rate, notably in patients who have specific genetic mutations that are generally associated with a poor prognosis. Ongoing research continues to investigate Idelalisib’s effectiveness and safety in combination with other medications and for other indications. This underscores the importance of regular check-ins with your healthcare provider or our telemedicine team to ensure you are benefiting from the most current treatment strategies.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.