Understanding Helidac: Medication Profile

Names of Medication

The brand name for this medication is Helidac (Bismuth Subsalicylate/Metronidazole/Tetracycline Hydrochloride).

Pharmacologic Category

Helidac is a combination of three different drugs, each belonging to a different pharmacologic category. Bismuth subsalicylate is an antacid, metronidazole is an antibiotic, and tetracycline hydrochloride is a tetracycline antibiotic. Other medications in these categories include Pepto-Bismol (bismuth subsalicylate), Flagyl (metronidazole), and Sumycin (tetracycline).

Dosing

Helidac is used in the treatment of the following diseases in adults:
Helicobacter pylori infection: The standard dosing is 2 chewable tablets of bismuth subsalicylate (262 mg each), 1 capsule of tetracycline (500 mg), and 1 capsule of metronidazole (250 mg) taken four times a day (morning, noon, evening, and bedtime) for 14 days.
Peptic ulcer disease: Helidac is used in combination with an H2 antagonist for the treatment of active duodenal ulcer associated with H. pylori infection, with the same dosing as above.
It is important to note that patients should not adjust the dose of their medication without first speaking with their doctor.

Dosage Forms and Strengths

Helidac comes in a therapy pack containing chewable tablets of bismuth subsalicylate (262 mg) and capsules of metronidazole (250 mg) and tetracycline hydrochloride (500 mg).

Administration Instructions

The medication should be taken with meals and at bedtime, preferably with a full glass of water. The bismuth subsalicylate tablets should be chewed and swallowed. Metronidazole and tetracycline capsules should be swallowed whole, not crushed or chewed.

Adverse Reactions and Side Effects

Like any medication, Helidac can cause side effects. These may include:
Nausea (Common): This can occur as your body adjusts to the medication. Nausea is thought to be caused by the direct effect of the drugs on the stomach lining.
Metallic taste (Common): Metronidazole often causes a metallic taste in the mouth. It’s due to changes in the way your taste buds perceive different flavors.
Darkened tongue and/or black stool (Common): This is caused by the bismuth subsalicylate and is harmless.
Diarrhea (Less Common): This may be caused by the antibiotics disrupting the normal gut flora. If severe, it could indicate a serious condition known as Clostridium difficile-associated diarrhea.
Neurological symptoms (Rare): These can include dizziness, loss of balance, or seizures, and are more likely to occur with prolonged use or high doses of metronidazole.

Contraindications to Taking Helidac

Contraindication means a condition or factor that serves as a reason to withhold a certain medical treatment. Helidac should not be used in the following situations:
Allergy to any component: Patients with known hypersensitivity to bismuth subsalicylate, metronidazole, or tetracycline should not take Helidac.
Renal Impairment: In patients with renal impairment

Renal Impairment

In patients with renal impairment, the use of tetracycline, one of the components of Helidac, can lead to a buildup of the drug in the body, causing further kidney damage and other serious complications.

Pregnancy

Helidac should not be used in pregnant women due to the potential for fetal harm. Tetracycline, a component of Helidac, can cause permanent discoloration of teeth and inhibit bone growth in the developing fetus.

Drug to Drug Interactions

Certain medications can interact with Helidac. Some significant interactions include:
Anticoagulants like Warfarin (Coumadin): Metronidazole can potentiate the anticoagulant effect, increasing the risk of bleeding.
Antacids containing aluminum, calcium, or magnesium; supplements and products containing iron, zinc, calcium, magnesium, or bismuth: These can bind to tetracycline and prevent its absorption, reducing its effectiveness.
Disulfiram (Antabuse): Concurrent use with metronidazole can cause a psychotic reaction.

Helidac in Pregnancy

Helidac should not be used during pregnancy. Tetracycline can cause harm to the developing fetus, including permanent discoloration of teeth and potential inhibition of bone growth.

Helidac while Breastfeeding

Helidac should be used with caution in breastfeeding women. Metronidazole is excreted in breast milk and may cause side effects in the nursing infant, while tetracycline can affect tooth and bone development.

Estimated Cost of Medication

The estimated cost for a 14-day course of Helidac, without insurance and using a GoodRx coupon, is around $150-$200. However, prices can vary depending on the pharmacy and location, and they are subject to change based on negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

Meta Title: Helidac Medication Profile: Understanding Uses, Side Effects, and More Meta Description: Learn about Helidac, including its uses, side effects, and interactions. This comprehensive guide helps patients understand this medication used for H. pylori infection and peptic ulcer disease.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.