Medication Profile: Granisetron

Summary or Key Points

Granisetron is a prescription medication primarily used for the prevention of nausea and vomiting caused by chemotherapy or radiation therapy. As part of the antiemetics class of drugs, it works by blocking a certain natural substance (serotonin) in the body that can cause vomiting. It’s crucial to consult your healthcare provider before adjusting the dosage. For immediate consultation, our telemedicine providers are available.

Names of Medication

US Brand Name: Kytril (Granisetron)

The term in the parenthesis is the generic name of the medication. The generic name is the standard name of the active ingredient in the medicine. It’s important to note that the same generic drug may be sold under different brand names.

Pharmacologic Category

Granisetron is an antiemetic, belonging to the 5-HT3 receptor antagonist class of drugs. Other medications in this category include ondansetron (Zofran), palonosetron (Aloxi), and dolasetron (Anzemet).

Dosing

For nausea and vomiting caused by chemotherapy or radiation therapy, the recommended adult dosage is 2 mg orally once daily or 1 mg twice daily. This should be taken within one hour of chemotherapy or radiation therapy and can continue for up to 1 week after your therapy ends. Always consult with your healthcare provider before adjusting your dosage. If you need to consult a provider right away, our telemedicine team is ready to help.

Dosage Forms and Strengths

• Tablets: 1 mg and 2 mg
• Oral solution: 2 mg/10 mL
• Injection: 1 mg/mL

Administration Instructions

Take Granisetron exactly as your healthcare provider instructs. Do not change the dose or stop taking the medication without first consulting your provider. For immediate consultation, our telemedicine service is available.

Adverse Reactions and Side Effects

Side effects of Granisetron may include:

• Headache (common)
• Constipation (common)
• Diarrhea (less common)
• Stomach pain (less common)
• Weakness (rare)

If you experience any of these side effects persistently or they worsen, contact your healthcare provider immediately. If you need immediate consultation, our telemedicine service is available.

Contraindications

A contraindication is a condition or factor that suggests a particular medication should not be used because it may be harmful to the patient. Granisetron is contraindicated in patients who have a known allergy to the drug, as this can cause severe hypersensitivity reactions. Always let your healthcare provider know about any allergies or adverse reactions you have had to medications in the past. Our telemedicine providers are readily available to discuss any concerns you may have.

Drug to Drug Interactions

Certain medications may interact with Granisetron. These include:

• Phenobarbital (Luminal)
• Rifampin (Rifadin, Rimactane)

These medications may decrease the effectiveness of Granisetron. Always consult your healthcare provider before starting any new medications. Our telemedicine providers are ready to help answer any questions you might have.

Granisetron in Pregnancy

Current evidence suggests that Granisetron should only be used during pregnancy if clearly needed, as there are no adequate and well-controlled studies in pregnant women. Always consult your healthcare provider if you are pregnant or planning to become pregnant before taking any medication. Our telemedicine providers can provide immediate guidance.

Granisetron while Breastfeeding

It is not known whether Granisetron is excreted in human milk. Therefore, caution should be exercised when considering Granisetron for a nursing woman. As always, it’s crucial to consult with your healthcare provider before making any decisions. Our telemedicine team is ready for immediate consultation.

Estimated Cost of Medication

The estimated cost for a 30-day supply of Granisetron, without insurance and using a GoodRx coupon, is approximately $70 for 2mg tablets.

Possible Alternatives

For nausea and vomiting caused by chemotherapy or radiation therapy, alternatives may include other antiemetics such as Ondansetron (Zofran) or lifestyle changes like dietary modifications and stress management techniques. Always discuss these alternatives with your healthcare provider before making changes to your treatment plan. For immediate consultation, our telemedicine service is readily available.

Recent Updates on Granisetron Research

Recent studies suggest Granisetron may have potential benefits beyond its traditional use. Research is being conducted into its efficacy in treating post-operative nausea and vomiting. However, more comprehensive studies are required to determine the validity of these potential uses. Remember, any changes to your medication should always be discussed with your healthcare provider. Our telemedicine providers are ready to help with any questions or concerns you might have.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.