Understanding Esomeprazole/Naproxen: A Comprehensive Medication Profile

Names of Medication

Vimovo is the brand name for the combination of two drugs: Esomeprazole (a proton pump inhibitor) and Naproxen (a nonsteroidal anti-inflammatory drug or NSAID).

Pharmacologic category

This combination medication falls under the pharmacological categories of proton pump inhibitors (PPIs) and nonsteroidal anti-inflammatory drugs (NSAIDs). Other drugs in these categories include omeprazole (Prilosec), pantoprazole (Protonix), ibuprofen (Advil, Motrin), and celecoxib (Celebrex).

Dosing

Esomeprazole/Naproxen (Vimovo) is used to treat various conditions in adults:
Rheumatoid arthritis: The typical dose is one tablet twice daily, taken at least 30 minutes before meals.
Osteoarthritis: The usual dose is one tablet twice daily, again, taken at least 30 minutes before meals.
Gastroesophageal reflux disease (GERD): The dosage will depend on the severity of symptoms and is usually decided by the physician.
Peptic ulcer disease: For prevention of ulcers related to NSAID use, one tablet is typically taken twice daily, 30 minutes before meals.
Remember, it’s important not to adjust your dosage without consulting your healthcare provider first.

Dosage Forms and the strengths

Esomeprazole/Naproxen (Vimovo) is available in two strengths: 20 mg of esomeprazole with 375 mg of naproxen, and 20 mg of esomeprazole with 500 mg of naproxen.

Administration Instructions

Take this medication orally at least 30 minutes before meals, usually twice daily or as directed by your healthcare provider. Do not lie down for at least 10 minutes after taking this drug.

Adverse Reactions and Side Effects

As with any medication, Esomeprazole/Naproxen can cause side effects. These include:
Nausea (Common): This occurs as the medication may irritate the stomach lining, triggering feelings of nausea.
Headache (Common): This is a common side effect of many medications, including NSAIDs like naproxen.
Stomach or abdominal pain (Common): This can occur as NSAIDs, like naproxen, can cause stomach irritation.
Diarrhea (Less Common): This can occur as esomeprazole changes the acidity in your stomach, which can affect the balance of your gut bacteria.
Always contact your healthcare provider if you experience any severe or persistent side effects.

Contraindications to taking Esomeprazole/naproxen

Contraindications are conditions or factors that serve as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. This medication is contraindicated in patients with:
Known allergy to esomeprazole, naproxen, or other NSAIDs.
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
History of coronary artery bypass graft (CABG) surgery

Drug to Drug Interactions

Esomeprazole/Naproxen can interact with several other medications. These include:
Anticoagulants (Warfarin): Esomeprazole/Naproxen can increase the risk of bleeding if taken with anticoagulants.
Angiotensin-converting enzyme (ACE) inhibitors (Lisinopril) and Angiotensin II receptor blockers (Losartan): Naproxen can reduce the blood pressure-lowering effects of these medications.
Selective serotonin reuptake inhibitors (SSRIs) (Fluoxetine, Sertraline): Taking these drugs with Esomeprazole/Naproxen can increase the risk of gastrointestinal bleeding.

Esomeprazole/Naproxen in Pregnancy

Esomeprazole/Naproxen should be avoided during pregnancy, especially in the third trimester, as it may cause harm to the fetus. Always consult with your healthcare provider for more personalized advice.

Esomeprazole/Naproxen while Breastfeeding

While naproxen is generally considered safe to use during breastfeeding, esomeprazole should be used with caution. If you are breastfeeding and need to take this medication, it’s important to discuss the risks and benefits with your healthcare provider.

Estimated Cost of Medication

The estimated cost for a 30-day supply of Esomeprazole/Naproxen (Vimovo) without insurance, using a GoodRx coupon, is around $200-$300, but this can vary depending on location and pharmacy. Remember, these are only estimates and prices can change based on negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.