A Comprehensive Guide to Eluxadoline

Names of Medication

The medication is known by the brand name Viberzi (Eluxadoline).

Pharmacologic Category

Eluxadoline is classified as a mixed opioid receptor agonist. Similar medications in this category include Loperamide (Imodium) and Diphenoxylate/Atropine (Lomotil).

Dosing

Eluxadoline is used in adults for the treatment of a specific condition:

Irritable Bowel Syndrome with Diarrhea (IBS-D)

The standard therapeutic dose for IBS-D is 100 mg taken orally twice daily. This treatment may continue for as long as symptoms persist or as directed by a healthcare provider. Always remember never to adjust your dose of medication without first consulting with your doctor.

Dosage Forms and Strengths

Eluxadoline is available in tablet form in the following strengths: 75 mg and 100 mg.

Administration Instructions

Eluxadoline tablets should be taken orally with food. If you miss a dose, take it as soon as you remember, but if it is near the time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Adverse Reactions and Side Effects

Like all medications, Eluxadoline may cause side effects. Here are some common and severe side effects:

Constipation (7-8%)

Constipation is a common side effect of Eluxadoline. This happens because Eluxadoline slows down the movement of the gut, leading to longer stool transit times. If constipation occurs, it’s typically manageable with over-the-counter medications but should be reported to your healthcare provider.

Abdominal Pain (7%)

Abdominal pain can occur with Eluxadoline due to its action on the gut. This medication works by reducing bowel contractions, which can sometimes lead to pain or discomfort. If abdominal pain occurs, it’s usually mild to moderate but should be reported to your healthcare provider.

Contraindications to taking Eluxadoline

A contraindication is a situation in which a drug should not be used because it may be harmful to the patient. Here are some contraindications for Eluxadoline:

Known Hypersensitivity to Eluxadoline

Patients with a known hypersensitivity to Eluxadoline or any of its components should not take this medication. Symptoms of a hypersensitivity reaction can include rash, itching, swelling, severe dizziness, or trouble breathing.

History of Biliary Duct Obstruction

Eluxadoline can cause contractions in the biliary tract. Therefore, patients with a history of biliary duct obstruction should not use this medication as it may exacerbate their condition.

h2>Drug to Drug Interactions

Certain drugs may interact with Eluxadoline, potentially altering its effectiveness and side effect profile. Here are some significant interactions:
Opioids (e.g., Morphine, Codeine)
Anticholinergics (e.g., Atropine, Scopolamine)
Loper
Loperamide (Imodium)
These medications can increase the risk of severe constipation and blockage in your intestines.

Eluxadoline in Pregnancy

There is limited information available on the use of Eluxadoline during pregnancy. Therefore, it should only be used if the potential benefits justify the potential risks to the fetus. Consult your healthcare provider for more personalized advice.

Eluxadoline while Breastfeeding

It’s unknown whether Eluxadoline passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Estimated Cost of Medication

As of this writing, the estimated cost of a 30-day supply of Eluxadoline (Viberzi) is about $1400-$1600 for the 75mg dose, and $1500-$1700 for the 100mg dose when using a GoodRx coupon. Prices may vary depending on the pharmacy, location, and changes in negotiated agreements between pharmacies and pharmaceutical companies. These estimates do not include insurance copayments or deductibles.

Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.