Medication Profile: Eluxadoline

Summary or Key Points

Eluxadoline is an effective medication for the treatment of certain types of Irritable Bowel Syndrome (IBS). It aids in reducing stomach cramps and diarrhea associated with IBS. However, like all medications, it has potential side effects that patients should be aware of. As always, discuss any questions or concerns about Eluxadoline with your healthcare provider, or schedule a telemedicine consultation with one of our providers.

Names of Medication

US Brand Name: Viberzi (Eluxadoline)

The ‘generic name’ (Eluxadoline in this case) is the official, non-branded name of a medication, whereas the ‘brand name’ (Viberzi) is the commercial, marketed name. The generic name is placed in parenthesis for clarity.

Pharmacologic Category

Eluxadoline belongs to a class of drugs known as mixed opioid receptor agonists/antagonists. Other medications in this category include Butorphanol and Nalbuphine.

Dosing

Eluxadoline is indicated for the treatment of Irritable Bowel Syndrome with Diarrhea (IBS-D) in adults. The usual dosage is 100 mg orally twice daily. The length of treatment varies and should be determined by your healthcare provider. Always consult your doctor or our telemedicine provider before adjusting your dose.

Dosage Forms and Strengths

Eluxadoline (Viberzi) is available in the following forms and strengths:

• Tablet, Oral: 75 mg
• Tablet, Oral: 100 mg

Administration Instructions

Eluxadoline tablets should be taken orally with food. It’s important to swallow the tablet whole and not to crush or chew it. Always take this medication exactly as prescribed by your healthcare provider. Should you have any doubts or questions, don’t hesitate to consult with one of our telemedicine providers.

Adverse Reactions and Side Effects

While Eluxadoline can be beneficial, it may also cause some side effects. Not everyone will experience these, but if they do occur, they may need medical attention. Side effects can include:

• Common (may affect up to 1 in 10 people): constipation, nausea, and abdominal pain.
• Uncommon (may affect up to 1 in 100 people): vomiting, dizziness, or an increase in liver enzymes.

If you notice any side effects, promptly contact your healthcare provider or one of our telemedicine providers.

Contraindications

A contraindication is a specific situation in which a drug, procedure, or surgery should not be used because it may be harmful to the person. Here are the contraindications for Eluxadoline:

• Severe liver impairment: Eluxadoline can potentially harm the liver, so it’s not safe for people with severe liver disease.
• Alcoholism or a history of alcohol abuse: Due to the potential for liver damage, it’s contraindicated in those with alcoholism or a history of alcohol abuse.
• History of pancreatitis or other pancreatic disease: Eluxadoline can cause pancreatitis, so it’s not recommended for those with a history of this condition.

If you have any of these conditions, it’s important to discuss this with your healthcare provider or one of our telemedicine providers.

Drug to Drug Interactions

There are medications that can interact with Eluxadoline, potentially affecting its effectiveness or causing unwanted side effects. Examples include:

• Opioid medications, such as Morphine (MS Contin), Hydrocodone (Vicodin), or Oxycodone (OxyContin).
• Loperamide (Imodium), an over-the-counter medication used to control diarrhea.

Eluxadoline in Pregnancy

There is limited data on the use of Eluxadoline during pregnancy. Always consult your healthcare provider or one of our telemedicine providers if you are pregnant or planning to become pregnant while taking this medication.

Eluxadoline while Breastfeeding

It is not known if Eluxadoline passes into breast milk. If you are breastfeeding, please consult your healthcare provider or one of our telemedicine providers before taking this medication.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Eluxadoline (100 mg) is approximately $270-$300 without insurance but with a GoodRx coupon.

Possible Alternatives

For Irritable Bowel Syndrome (IBS), potential alternative treatments may include lifestyle changes like a modified diet, stress management techniques, and other medications. As always, it’s important to discuss any potential changes to your treatment plan with your healthcare provider or one of our telemedicine providers.

Recent Updates on Eluxadoline Research

Recent studies have shown that Eluxadoline is an effective and safe treatment for IBS-D when taken as directed. Ongoing research aims to further understand its long-term effects and potential uses. Always consult with your healthcare provider or one of our telemedicine providers for the most up-to-date information.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.