Domperidone: A Comprehensive Medication Profile for Patients

Names of Medication

US Brand Name: Motilium (Domperidone)

Pharmacologic Category

Domperidone belongs to the pharmacologic category of prokinetic agents. Other medications in this category include: – Metoclopramide (Reglan) – Cisapride (Propulsid) – Erythromycin (Ery-Tab, EryPed)

Dosing

Domperidone is used to treat the following conditions in adults:
Gastroparesis
Gastroesophageal reflux disease (GERD)
Nausea and vomiting
Dosage and treatment duration vary depending on the condition being treated. Always consult your doctor before adjusting your medication dosage, and never make changes without their guidance.

Gastroparesis

Initial dosing: 10 mg three times daily, before meals. Standard therapeutic dose: 10-20 mg three to four times daily, before meals. Maximum dose: 80 mg per day. Minimum dose: 10 mg three times daily, before meals. Treatment duration: As prescribed by your doctor.

Gastroesophageal Reflux Disease (GERD)

Initial dosing: 10 mg three times daily, before meals. Standard therapeutic dose: 10-20 mg three to four times daily, before meals. Maximum dose: 80 mg per day. Minimum dose: 10 mg three times daily, before meals. Treatment duration: As prescribed by your doctor.

Nausea and Vomiting

Initial dosing: 10 mg three times daily, before meals. Standard therapeutic dose: 10-20 mg three to four times daily, before meals. Maximum dose: 80 mg per day. Minimum dose: 10 mg three times daily, before meals. Treatment duration: As prescribed by your doctor.

Dosage Forms and Strengths

Domperidone is available in the following forms and strengths:
Tablets: 10 mg

Administration Instructions

Domperidone tablets should be taken 15-30 minutes before meals and at bedtime if necessary. If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Adverse Reactions and Side Effects

Domperidone may cause side effects. Always inform your doctor if you experience any adverse reactions while taking this medication. Some side effects and their frequencies include:
Dry mouth (common): Domperidone can affect saliva production, which may result in a dry mouth.
Headache (common): This may occur due to changes in blood flow caused by the drug’s action on dopamine receptors.
Abdominal cramps (less common): This can occur due to increased gut motility and gastric emptying.
Rash or itching (rare): This may occur due to an allergic reaction to the medication.

Contraindications to taking Domperidone

A contraindication is a specific situation in which a drug, procedure, or surgery should not be used because it may be harmful to the person. Domperidone is contraindicated in the following situations:
Known allergy to domperidone or any components of the tablet.
A history of abnormal heart rhythms, or other significant heart diseases.
Concurrent use of certain medications, such as ketoconazole, that can interact with domperidone.
Presence of gastrointestinal bleeding, obstruction, or perforation.
Each contraindication is a situation in which the potential risks of taking Domperidone outweigh the potential benefits. Always inform your doctor about your medical history and all the medications you are taking.

Drug to Drug Interactions

Significant interactions can occur between Domperidone and the following medications:
Ketoconazole (Nizoral)
Erythromycin (Ery-Tab, EryPed)
Certain antidepressants, like fluoxetine (Prozac)
Certain heart medications, like amiodarone (Cordarone)
Always inform your healthcare provider about all the medications you are currently taking, including over-the-counter medications, to avoid possible drug interactions.

Domperidone in Pregnancy

While Domperidone is not known to cause harm to unborn babies, it should only be used during pregnancy if the potential benefits outweigh the potential risks. Always consult your healthcare provider if you are pregnant or planning to become pregnant while taking this medication.

Domperidone while Breastfeeding

Domperidone passes into breast milk in small amounts and could potentially affect a nursing infant. Consult your healthcare provider before using Domperidone if you are breastfeeding.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Domperidone 10mg tablets without insurance, using a GoodRx coupon, is approximately $30. Prices may vary depending on the pharmacy and location. Remember, this is an estimate and actual prices may vary.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.