Diphenhydramine: Key Facts, Uses, and Side Effects

Summary or Key Points

Diphenhydramine is an antihistamine that provides relief from allergy symptoms, motion sickness, and aids in sleep. It’s essential to understand the correct dosage, forms, administration instructions, and possible side effects. Always consult a healthcare provider, such as our telemedicine providers, for personalized advice and information.

Names of Medication

US Brand Name: Benadryl (Diphenhydramine)

The term ‘generic name’ refers to the standard name of the drug, not specific to any brand. It’s the name given in parentheses.

Pharmacologic Category

Other medications in the same pharmacologic category as Diphenhydramine include: Cetirizine, Loratadine, Fexofenadine, and Hydroxyzine.

Dosing

Before adjusting your dosage of Diphenhydramine, consult with your healthcare provider. Our telemedicine providers are available for immediate consultation. Here are common uses and respective dosages:

• Allergy Symptoms: 25-50 mg every 4-6 hours, not to exceed 300 mg/day.
• Motion Sickness: 25-50 mg every 4-6 hours, not to exceed 300 mg/day.
• Insomnia (Off-label use): 50 mg at bedtime.

Dosage Forms and Strengths

Diphenhydramine is available in various forms and strengths:

• Oral tablets: 25mg, 50mg
• Oral liquid: 12.5mg/5mL, 50mg/mL
• Injection: 50mg/mL
• Topical cream: 2%

Administration Instructions

Take Diphenhydramine orally with or without food. If stomach upset occurs, taking it with food or milk might help. Use the measuring cup provided for the liquid form. If you’re using the topical cream, apply it to the affected area no more than 3 to 4 times daily. For any further instructions, consult with our telemedicine providers.

Adverse Reactions and Side Effects

Like all medications, Diphenhydramine can cause side effects, though not everyone gets them. If you experience any of these, immediately consult with our telemedicine providers:

• Common (may affect up to 1 in 10 people): Drowsiness, dizziness, constipation, upset stomach.
• Uncommon (may affect up to 1 in 100 people): Dry mouth, nose, or throat, blurred vision, difficulty urinating.
• Rare (may affect up to 1 in 1,000 people): Confusion, hallucinations, rash, itching, difficulty breathing.

Contraindications and Drug Interactions

Diphenhydramine should not be used if you have certain medical conditions, such as severe asthma, glaucoma, or an enlarged prostate. Furthermore, interactions may occur with other medications, including sedatives, tranquilizers, and certain antidepressants. Always consult your healthcare provider before starting Diphenhydramine. Our telemedicine providers are ready to help you understand these risks.

Pregnancy and Breastfeeding

Diphenhydramine should only be used during pregnancy or while breastfeeding if the benefits outweigh the risks. It’s crucial to consult a healthcare provider before use; you can schedule a consultation with one of our telemedicine providers for personalized advice.

Overdose

Overdose symptoms may include nausea, vomiting, loss of coordination, and seizures. If an overdose is suspected, contact a healthcare provider immediately. Remember, our telemedicine services are available for immediate consultation and support.

Storage

Store Diphenhydramine at room temperature, away from light and moisture. Do not store in the bathroom, and keep all medications away from children and pets. For specific storage instructions, consult with our telemedicine providers.

Conclusion

Understanding your medication is crucial for effective treatment and minimizing side effects. Always consult a healthcare provider for personalized information. If you have further questions about Diphenhydramine or need medical consultation, consider reaching out to one of our telemedicine providers, who are always here to assist you.

Contraindications

A contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Diphenhydramine should not be taken in certain situations:

• Severe asthma: Diphenhydramine can thicken lung secretions, making it harder for those with severe asthma to breathe.
• Glaucoma: This medication may increase eye pressure, worsening glaucoma.
• Enlarged prostate: Diphenhydramine might cause problems urinating, which can worsen symptoms of an enlarged prostate.

Always discuss these conditions with a healthcare provider before using Diphenhydramine. Consult our telemedicine providers for immediate help.

Drug to Drug Interactions

There are several medications that interact with Diphenhydramine. Here are a few:

• Ambien (Zolpidem)
• Ativan (Lorazepam)
• Benadryl (Diphenhydramine)
• Lyrica (Pregabalin)
• Xanax (Alprazolam)

Diphenhydramine in Pregnancy

It’s generally safe to take Diphenhydramine when pregnant, but only under the guidance of a healthcare provider. Each case is unique, and potential risks should be discussed with a healthcare professional. Our telemedicine providers can provide immediate advice.

Diphenhydramine while Breastfeeding

Small amounts of Diphenhydramine can pass into breast milk. While it’s typically safe, it’s best to consult a healthcare provider before use. Our telemedicine providers are available to provide more personalized advice.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Diphenhydramine without insurance, using a GoodRX coupon, is approximately $10-$15. Prices can vary depending on the pharmacy and the form of the drug.

Possible Alternatives

There are alternative treatments or lifestyle changes for each condition Diphenhydramine is indicated to treat. Always discuss these alternatives with your healthcare provider before making changes to your treatment plan:

• Allergy Symptoms: Antihistamines like Loratadine or nasal steroids. Also, avoiding allergens and maintaining a clean environment can help.
• Motion Sickness: Other medications like Meclizine or natural remedies such as ginger. Habitual changes such as looking at the horizon can also help.
• Insomnia (Off-label use): Prescription sleep aids or natural remedies like Melatonin. Practicing good sleep hygiene and cognitive-behavioral therapy are also beneficial.

Recent Updates on Diphenhydramine Research

As of our latest update, research is ongoing about the long-term effects of Diphenhydramine and other antihistamines on cognitive function in elderly patients. More studies are needed to clarify these findings and their clinical significance. For the most current and relevant information, consider discussing with one of our telemedicine
providers.

Conclusion

Understanding your medication is a crucial part of effective treatment. It’s important to be aware of possible side effects, contraindications, and drug interactions. Remember, if you have any further questions or concerns about Diphenhydramine or need immediate medical advice, consider reaching out to one of our telemedicine providers. They are always here to assist you in understanding your condition and the best possible treatment plan for you.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.