Understanding Dexlansoprazole: A Comprehensive Guide for Patients

Names of Medication

Dexlansoprazole is marketed in the United States under the brand name Dexilant (Dexlansoprazole).

Pharmacologic Category

Dexlansoprazole belongs to a class of medications known as proton pump inhibitors (PPIs). Other medications in this class include:
Omeprazole (Prilosec)
Esomeprazole (Nexium)
Lansoprazole (Prevacid)
Pantoprazole (Protonix)
Rabeprazole (Aciphex)

Dosing

Dexlansoprazole is used to treat a variety of conditions related to the stomach and esophagus. The dosage depends on the condition being treated:
Gastroesophageal reflux disease (GERD): 60 mg daily for up to 8 weeks.
Erosive esophagitis: 60 mg daily for up to 8 weeks, with a potential additional 8 weeks if necessary.
Maintenance of healed erosive esophagitis: 30 mg daily.
Zollinger-Ellison syndrome: The dose varies and is individualized based on the patient’s needs.
Remember, you should never adjust your dose or dosing schedule without consulting your healthcare provider.

Dosage Forms and Strengths

Dexlansoprazole comes in delayed-release capsules in strengths of 30 mg and 60 mg.

Administration Instructions

Dexlansoprazole should be taken once daily, without regard to food. The capsule should be swallowed whole and should not be crushed, chewed, or broken.

Adverse Reactions and Side Effects

Like all medications, Dexlansoprazole can cause side effects. Common side effects include:
Diarrhea (up to 4.8%): This can occur due to changes in the digestive system caused by the medication. If severe, contact your healthcare provider.
Abdominal pain (up to 4.0%): This is often mild and temporary. If persistent or severe, seek medical attention.
Nausea (up to 2.9%): This can be reduced by taking the medication with food.
Remember to report any unusual or severe side effects to your healthcare provider.

Contraindications to Taking Dexlansoprazole

Contraindications refer to conditions or factors that serve as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Dexlansoprazole is contraindicated in:
Individuals with known hypersensitivity to Dexlansoprazole or other proton pump inhibitors. This can result in allergic reactions, including anaphylaxis.
Patients taking the anti-HIV medication rilpivirine (Edurant, Complera). Dexlansoprazole can decrease the effectiveness of rilpivirine, potentially leading to treatment failure.
Always inform your healthcare provider about your full medical history and any medications you are currently taking.

Drug to Drug Interactions

Dexlansoprazole can interact with other medications, affecting their efficacy or increasing the risk of side effects.

Significant Drug Interactions

Rilpivirine (Edurant, Complera): Dexlansoprazole can reduce the absorption of this medication, making it less effective.
Warfarin (Coumadin, Jantoven): Dexlansoprazole can increase the blood-thinning effect of warfarin, increasing the risk of bleeding.
Methotrexate (Trexall, Rheumatrex): Concurrent use can increase methotrexate levels, leading to toxicity.
Digoxin (Lanoxin): Dexlansoprazole can increase the absorption of digoxin, potentially leading to toxicity.
Always discuss potential interactions with your healthcare provider before starting a new medication.

Dexlansoprazole in Pregnancy

Dexlansoprazole is classified as a pregnancy category B drug by the FDA. This means that studies in animals have not shown a risk to the fetus, but there are no adequate studies in pregnant women. You should only use this medication during pregnancy if clearly needed and after discussing potential risks and benefits with your healthcare provider.

Dexlansoprazole While Breastfeeding

It is not known if Dexlansoprazole passes into breast milk. Consult your healthcare provider before breastfeeding while taking this medication.

Estimated Cost of Medication

The estimated cost for a 30-day supply of Dexlansoprazole 60 mg (Dexilant) without insurance and using a GoodRx coupon is approximately $250, but this can vary based on location and pharmacy. These prices are only estimates and can change based on negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Remember, taking medication is a serious commitment and should be done with the full understanding of the benefits and potential risks. Always communicate openly with your healthcare provider, and ask questions if you have any doubts or concerns about your medication.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.