Dabrafenib: A Comprehensive Medication Profile

Summary or Key Points

Dabrafenib is a targeted therapy primarily used to treat certain types of melanoma and non-small cell lung cancer. It operates by blocking abnormal proteins in cancer cells, impeding their growth and spread. The drug comes in varying strengths and may trigger several side effects, though these vary by individual. Always consult a healthcare provider before adjusting your dosage, and remember, our telemedicine service allows easy access to medical consultations.

Names of Medication

US Brand Name: Tafinlar (Generic name: Dabrafenib)

The ‘generic name’ refers to the official, scientific name of the drug, often reflecting its chemical structure or the way it works in the body. Here, we’ve provided the generic name in parentheses for clarity and reference.

Pharmacologic Category

Dabrafenib falls under the pharmacologic category of BRAF inhibitors. Other medications in this group include Vemurafenib (Zelboraf) and Encorafenib (Braftovi).

Dosing

The following are the indications, dosages, and lengths of treatment for Dabrafenib:

• Melanoma: The typical dosage for adults with metastatic melanoma carrying the BRAF V600 mutation is 150 mg twice daily. Treatment continues until disease progression or until the patient cannot tolerate the side effects.
• Non-Small Cell Lung Cancer: For adults with metastatic non-small cell lung cancer with the BRAF V600E mutation, the recommended dose is also 150 mg twice daily, continuing as long as the disease doesn’t progress or until side effects become intolerable.

Always consult your healthcare provider before adjusting your dose. Our telemedicine services can provide immediate assistance with medication management.

Dosage Forms and Strengths

Dabrafenib is available in the following forms and strengths:

• 50 mg capsules
• 75 mg capsules

Administration Instructions

Dabrafenib should be taken orally, twice a day, at least one hour before or two hours after a meal. Swallow the capsule whole and do not open, break, or chew it. As with any medication, always follow the specific instructions provided by your healthcare provider. Should you have questions, our telemedicine service can provide you with professional consultation anytime, anywhere.

Adverse Reactions and Side Effects

While Dabrafenib can be beneficial in managing certain diseases, it may also cause several side effects. Some people may experience none or only mild side effects, while others may experience more severe effects. Side effects may include:

• Common side effects: These may include headache, joint pain, skin rash, fever, fatigue, and nausea.
• Severe side effects: These can include vision changes, severe fever, chest pain, severe skin rash, or signs of liver problems such as yellowing of the skin or eyes.

Always inform your healthcare provider if you experience any side effects. With our telemedicine service, you can easily report and discuss these side effects with a healthcare provider.

Contraindications

A ‘contraindication’ is a specific situation or condition in which a drug should not be used because it may be harmful to the patient. Contraindications for Dabrafenib include:

• Allergy to Dabrafenib: Patients who have previously had a severe allergic reaction to Dabrafenib or any of its components should avoid its use.

Drug to Drug Interactions

It’s important to be aware that Dabrafenib may interact with other medications, potentially altering their effects. Some notable interactions include:

• Rifampin (Rifadin)
• Phenytoin (Dilantin)
• Carbamazepine (Tegretol)
• Warfarin (Coumadin)

Dabrafenib in Pregnancy

Dabrafenib may pose risks during pregnancy. Animal studies have suggested potential harm to the fetus, and there are limited human studies. If you are pregnant or planning to become pregnant, discuss this with your healthcare provider. Our telemedicine services can help facilitate this conversation.

Dabrafenib while Breastfeeding

It’s currently unknown if Dabrafenib passes into breast milk. Due to potential risks, it’s generally recommended that breastfeeding should be discontinued while taking Dabrafenib. Discuss this with your healthcare provider and take advantage of our telemedicine services for a consultation.

Estimated Cost of Medication

The estimated cost for a 30-day supply of Dabrafenib (75 mg), using a GoodRX coupon and without insurance, is approximately $9,200. Please note that prices may vary.

Possible Alternatives

While Dabrafenib is often effective, there may be alternative treatments or lifestyle changes that can aid in managing your condition. For each disease, consider:

• Melanoma: Other treatments may include surgery, immunotherapy, other targeted therapies, chemotherapy, or radiation therapy. Lifestyle changes such as sun protection can help prevent melanoma.
• Non-Small Cell Lung Cancer: Other treatments can include surgery, radiation therapy, immunotherapy, chemotherapy, or targeted therapies. Lifestyle changes like quitting smoking can decrease the risk of lung cancer.

Always discuss potential alternatives with your healthcare provider before making any changes to your treatment plan. Our telemedicine services can provide a platform for these discussions.

Recent Updates on Dabrafenib Research

Research on Dabrafenib is ongoing. Recent studies have explored the drug’s effectiveness when used in combination with other treatments, potentially expanding its use to other types of cancer. For instance, a combination of Dabrafenib and Trametinib has shown promise in treating BRAF V600 mutation-positive anaplastic thyroid cancer. Always consult your healthcare provider for the most recent and relevant information about your treatment. Our telemedicine service is here to provide up-to-date consultations.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.