Encorafenib Treatment: Uses, Dosage, Side Effects, and Cost Guide

Key Points About Encorafenib Treatment

Encorafenib is a prescription medication used to treat certain types of cancer, including melanoma and colorectal cancer. It works by targeting and inhibiting specific proteins that contribute to cancer cell growth. Typically, it is used in combination with other treatments, such as binimetinib. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine service is available to help you manage your treatment plan from the comfort of your home.

Names of Encorafenib Medication

US Brand Name: Braftovi

Generic Name: Encorafenib

The generic name refers to the chemical composition of the medication, while the brand name is assigned by the manufacturer. The generic name is often listed in parentheses.

Pharmacologic Category of Encorafenib

Encorafenib belongs to a class of medications known as BRAF Kinase Inhibitors. This type of targeted cancer therapy works by blocking the BRAF protein, which plays a key role in cell growth and division.

Encorafenib Dosage for Different Cancer Types

Encorafenib is used to treat various cancers in adults. The dosage depends on the type of cancer being treated. Always follow your doctor’s instructions and consult them before making any changes to your dose. If needed, you can schedule a telemedicine appointment with us for further guidance.

Encorafenib for Melanoma

For melanoma with a BRAF V600E or V600K mutation, the recommended dose is 450 mg taken orally once daily in combination with binimetinib. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Colorectal Cancer

For colorectal cancer with a BRAF V600E mutation, the recommended dose is 300 mg taken orally once daily in combination with cetuximab. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Non-Small Cell Lung Cancer

The recommended dose for non-small cell lung cancer with a BRAF V600E mutation is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Thyroid Cancer

For thyroid cancer with a BRAF V600E mutation, the recommended dose is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Pancreatic Cancer

The recommended dose for pancreatic cancer with a BRAF V600E mutation is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Biliary Tract Cancer

For biliary tract cancer with a BRAF V600E mutation, the recommended dose is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Gastrointestinal Stromal Tumors

The recommended dose for gastrointestinal stromal tumors with a BRAF V600E mutation is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Breast Cancer

For breast cancer with a BRAF V600E mutation, the recommended dose is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Ovarian Cancer

The recommended dose for ovarian cancer with a BRAF V600E mutation is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib for Renal Cell Carcinoma

For renal cell carcinoma with a BRAF V600E mutation, the recommended dose is 300 mg taken orally once daily. Treatment continues until the disease progresses or unacceptable side effects occur.

Encorafenib Dosage Forms and Strengths

Encorafenib is available in capsule form with the following strengths:

1. 50 mg
2. 75 mg
3. 100 mg

How to Take Encorafenib: Administration Instructions

Encorafenib is taken orally, usually once daily, with or without food. Swallow the capsules whole with water; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. Do not take two doses at once. Always follow your healthcare provider’s instructions carefully.

Encorafenib Contraindications

A contraindication is a condition where a medication should not be used because it may cause harm. Before starting Encorafenib, it’s important to know if you have any conditions that could make this medication unsafe for you.

Here are some contraindications for taking Encorafenib:

1. Hypersensitivity to Encorafenib: If you’ve had an allergic reaction to Encorafenib or any of its components, you should not take this medication. Allergic reactions can cause symptoms like rash, itching, swelling, or difficulty breathing, which can be life-threatening.
2. Severe liver impairment: Encorafenib is processed by the liver. If you have severe liver disease, your body may not clear the drug properly, leading to increased side effects or toxicity.
3. Concurrent use with strong CYP3A4 inhibitors: Medications that strongly inhibit the CYP3A4 enzyme can increase Encorafenib levels in your body, raising the risk of severe side effects.

If you have any of these conditions, discuss them with your healthcare provider before starting Encorafenib. You can consult one of our providers through telemedicine to explore your options.

Encorafenib Drug Interactions

Encorafenib can interact with other medications, potentially increasing the risk of side effects or reducing its effectiveness. Below are some common medications that may interact with Encorafenib:

1. Ketoconazole (Nizoral): A strong CYP3A4 inhibitor that can increase Encorafenib levels in your body.
2. Rifampin (Rifadin): A strong CYP3A4 inducer that can lower Encorafenib levels, reducing its effectiveness.
3. Warfarin (Coumadin): Encorafenib may enhance the effects of blood thinners like warfarin, increasing the risk of bleeding.
4. Carbamazepine (Tegretol): This medication can reduce Encorafenib’s effectiveness by speeding up its breakdown in the liver.
5. Atorvastatin (Lipitor): Encorafenib may increase atorvastatin levels, raising the risk of muscle damage or liver problems.

Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. If you are unsure, our telemedicine providers can review your medication list and help you avoid harmful interactions.

Encorafenib in Pregnancy

Is it safe to take Encorafenib when pregnant?

Encorafenib is not considered safe during pregnancy, as it may harm an unborn baby, potentially leading to birth defects or pregnancy loss. If you are pregnant or planning to become pregnant, it is important to discuss alternative treatments with your healthcare provider. Women of childbearing potential should use effective contraception while taking Encorafenib and for at least two weeks after the last dose. If you become pregnant while on Encorafenib, contact your healthcare provider immediately.

Encorafenib while Breastfeeding

Is it safe to take Encorafenib while breastfeeding?

Breastfeeding is not recommended while taking Encorafenib. Although it is unclear whether Encorafenib passes into breast milk, the potential for serious side effects in a nursing infant means breastfeeding should be avoided during treatment and for at least two weeks after the final dose. If you are breastfeeding or planning to breastfeed, consult your healthcare provider to discuss the safest options for both you and your baby.

Estimated Cost of Encorafenib Treatment

The estimated cost for a 30-day supply of Encorafenib without insurance ranges from $12,000 to $15,000. However, using a GoodRx coupon may reduce the price to around $10,000. Prices can vary depending on location and pharmacy, so it’s advisable to check with different pharmacies and explore discount programs like GoodRx to find the most affordable option.

Possible Alternatives to Encorafenib

Depending on your condition, alternative treatments or lifestyle changes may help manage your disease. Always discuss these options with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these alternatives.

Melanoma Treatment Options

Other targeted therapies, such as vemurafenib (Zelboraf), or immunotherapies like pembrolizumab (Keytruda), may be considered. In addition, lifestyle changes, including sun protection and regular skin checks, are crucial for managing melanoma.

Colorectal Cancer Alternatives

Alternatives may include chemotherapy agents like FOLFOX or immunotherapies such as nivolumab (Opdivo). Additionally, maintaining a healthy diet and regular exercise can play a supportive role in managing colorectal cancer.

Non-Small Cell Lung Cancer Options

Immunotherapies like atezolizumab (Tecentriq) or targeted therapies such as osimertinib (Tagrisso) may be viable options. Quitting smoking and adopting a healthy lifestyle can also significantly improve outcomes.

Thyroid Cancer Treatment

Radioactive iodine therapy or targeted therapies like lenvatinib (Lenvima) may be used to treat thyroid cancer. Regular monitoring and maintaining a balanced diet are also important aspects of managing this condition.

Pancreatic Cancer Alternatives

Chemotherapy options like gemcitabine or FOLFIRINOX are commonly used alternatives. Maintaining a healthy weight and avoiding smoking can also help in managing pancreatic cancer.

Biliary Tract Cancer Options

Chemotherapy agents such as gemcitabine and cisplatin may be considered for biliary tract cancer. A healthy diet and regular physical activity may further support treatment efforts.

Gastrointestinal Stromal Tumors (GIST) Treatment

Other targeted therapies, such as imatinib (Gleevec), may be used to treat GIST. Regular follow-ups and a balanced diet are essential for managing this condition effectively.

Breast Cancer Alternatives

Hormonal therapies like tamoxifen or chemotherapy agents such as doxorubicin may be considered as alternatives. Regular exercise and a healthy diet can also play a key role in managing breast cancer.

Ovarian Cancer Treatment Options

Chemotherapy agents like carboplatin or targeted therapies such as bevacizumab (Avastin) may be considered for ovarian cancer. Maintaining a healthy weight and engaging in regular physical activity can support treatment and overall well-being.

Renal Cell Carcinoma Alternatives

Immunotherapies like nivolumab (Opdivo) or targeted therapies such as sunitinib (Sutent) may be alternatives for renal cell carcinoma. A healthy diet and regular exercise can also contribute to managing the disease.

Recent Updates on Encorafenib Research

Recent studies have focused on combining Encorafenib with other targeted therapies to improve outcomes in patients with BRAF-mutant cancers. For example, the combination of Encorafenib with cetuximab (Erbitux) has shown promising results in treating BRAF-mutant metastatic colorectal cancer. Additionally, ongoing clinical trials are exploring the use of Encorafenib alongside immunotherapies to enhance the immune system’s ability to fight cancer. While these studies are still in progress, early results are encouraging.

As research continues, new treatment options and combinations may become available. If you are interested in learning more about the latest developments or participating in a clinical trial, talk to your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to discuss your treatment options.

James Kingsley

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