Chlorambucil: A Comprehensive Medication Profile

Summary or Key Points

Chlorambucil is an effective chemotherapy drug used to manage Chronic Lymphocytic Leukemia and Non-Hodgkin’s Lymphoma. It works by slowing or stopping cancer cells’ growth. Though beneficial, it may cause some side effects, and its dosage varies based on the condition treated. Always consult your healthcare provider, such as our telemedicine professionals, for individualized treatment advice.

Names of Medication

US Brand Name: Leukeran (Chlorambucil)

A ‘generic name’ refers to the standard name of the medication, which is the same regardless of brand. In this case, Chlorambucil is the generic name, and it is shown in parentheses.

Pharmacologic Category

Chlorambucil belongs to the pharmacologic category of alkylating agents. Other medications in this group include cyclophosphamide, melphalan, and busulfan.

Dosing

• Chronic Lymphocytic Leukemia: Typically, the dose is 0.1 to 0.2 mg/kg/day orally for 3 to 6 weeks or until the white blood cell count normalizes. Always consult your healthcare provider, like our telemedicine specialists, to determine the appropriate dosage for you.
• Non-Hodgkin’s Lymphoma: Commonly, the dose is 0.1 to 0.2 mg/kg/day orally for several weeks. As with any medication, consult your healthcare provider for the dosage best suited to your condition.

Dosage Forms and Strengths

Chlorambucil is available in the form of a tablet in strengths of 2 mg.

Administration Instructions

Take Chlorambucil orally (by mouth) as directed by your healthcare provider. It can be taken with or without food. If nausea occurs, taking it with food may help. Your healthcare provider will determine the appropriate dosage and frequency based on your medical condition and response to therapy.

Adverse Reactions and Side Effects

Chlorambucil may cause several side effects, although not everyone will experience them. They include:

• Common (may affect up to 1 in 10 people): Nausea, vomiting, diarrhea, mouth sores, and decreased white blood cells.
• Uncommon (may affect up to 1 in 100 people): Skin rash, itching, and changes in liver function tests.
• Rare (may affect up to 1 in 1,000 people): Changes in skin color, seizures, and changes in mood or mental function.

Please note, this is not an exhaustive list. Always consult your healthcare provider, such as our available telemedicine professionals, if you notice any side effects or have concerns.

Contraindications

A contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the potential harm that it could cause the patient. Chlorambucil should not be used in the following circumstances:

• Known Allergy: Patients with known hypersensitivity to Chlorambucil or any of its components should avoid it due to potential allergic reactions.
• Pregnancy and Breastfeeding: Due to the potential harm to the fetus or newborn, Chlorambucil is contraindicated during pregnancy and breastfeeding.

Always consult your healthcare provider, such as our telemedicine professionals, before taking Chlorambucil to determine if it is suitable for you.

Drug to Drug Interactions

Drug interactions may change how medications work and increase the risk for serious side effects. Some drugs that can interact with Chlorambucil include:

• Phenytoin (Dilantin)
• Warfarin (Coumadin)

This list does not contain all possible drug interactions. It’s important to keep a list of all the products you use and share it with your healthcare provider, like our telemedicine specialists.

Chlorambucil in Pregnancy

It is not safe to take Chlorambucil during pregnancy. Chlorambucil can harm an unborn baby, causing potential birth defects or other complications. If you are pregnant or planning to become pregnant, discuss this with your healthcare provider.

Chlorambucil while Breastfeeding

Chlorambucil is not recommended while breastfeeding. It can pass into breast milk and may harm a nursing baby. If you are breastfeeding or plan to breastfeed, consult your healthcare provider before starting this medication.

Estimated Cost of Medication

Without insurance, a 30-day supply of Chlorambucil costs around $70 to $100 with a GoodRx coupon. The actual price may vary based on the pharmacy and location.

Possible Alternatives

• Chronic Lymphocytic Leukemia: Potential alternatives can include other chemotherapy drugs, targeted therapies, or stem cell transplant. Regular exercise and a balanced diet may also help improve overall health. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan.
• Non-Hodgkin’s Lymphoma: Radiation therapy, immunotherapy, and surgery are potential alternative treatments. A healthy lifestyle, including regular exercise and a balanced diet, could also be beneficial. Consult your healthcare provider, like our telemedicine experts, before considering these alternatives.

Recent Updates on Chlorambucil Research

Recent research continues to explore the benefits and effects of Chlorambucil in treating different forms of cancer. Some studies focus on the drug’s impact when used in combination with other treatments, while others investigate its long-term effects. It’s recommended to discuss with your healthcare provider for the most updated information on Chlorambucil’s research developments.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.