Chenodeoxycholic Acid: A Comprehensive Medication Profile

Summary or Key Points

Chenodeoxycholic Acid is a medication primarily used to treat gallstones and Cerebrotendinous Xanthomatosis (CTX). This medication works by reducing the production of cholesterol in the body, aiding in the dissolution of gallstones and managing the symptoms of CTX. Always consult with your healthcare provider or one of our telemedicine providers before starting or adjusting your dosage.

Names of Medication

US Brand Name: Chenodal (Chenodeoxycholic Acid)

The generic name, in this case, Chenodeoxycholic Acid, refers to the active ingredient in the medication. It’s common for drugs to be known by their brand and generic names. The generic name is often listed in parentheses to help you identify the active ingredient.

Pharmacologic Category

Chenodeoxycholic Acid is a part of the bile acid class of medications. Other medications in this category include Ursodeoxycholic Acid (Urso, Actigall) and Obeticholic Acid (Ocaliva).

Dosing

Chenodeoxycholic Acid is indicated to treat the following conditions in adults:

• Gallstones: The typical dosage is 250mg to 500mg per day, usually divided into two doses and taken for 6 months to 2 years or until the gallstones are dissolved. Always consult your doctor before adjusting your dosage.
• Cerebrotendinous Xanthomatosis (CTX): The dosage can vary widely based on individual patient needs, typically ranging from 15mg/kg per day divided into two or three doses. It’s generally used as a long-term treatment. Remember to consult your healthcare provider or one of our telemedicine professionals before starting or adjusting your dosage.

Dosage Forms and Strengths

Chenodeoxycholic Acid is available as an oral tablet in strengths of 250mg.

Administration Instructions

Chenodeoxycholic Acid should be taken by mouth. The dosage may be divided into two doses over the course of the day. This medication can be taken with or without food. Always follow your healthcare provider’s instructions when taking this medication.

Adverse Reactions and Side Effects

Like all medications, Chenodeoxycholic Acid can cause side effects. Not everyone will experience these side effects, but if they do occur, they may need medical attention. Side effects include:

• Common (may affect up to 1 in 10 people): Diarrhea, nausea, vomiting.
• Uncommon (may affect up to 1 in 100 people): Abdominal pain, skin rash.
• Rare (may affect up to 1 in 1,000 people): Liver damage, heartburn.

If you experience any of these side effects or have any concerns about your medication, reach out to your healthcare provider or contact one of our telemedicine providers right away.

Contraindications

In medicine, a contraindication refers to a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm it would cause the patient. Chenodeoxycholic Acid should not be taken in the following situations:

• Acute inflammation of the gallbladder or bile duct: This could worsen inflammation and cause further complications.
• Common bile duct obstruction: The medication cannot reach the gallbladder effectively, reducing its efficacy.
• Liver disease or liver failure: Chenodeoxycholic Acid is metabolized in the liver, and liver disease could impair this process, leading to potential toxicity.

Always consult your healthcare provider or one of our telemedicine professionals before starting any new medication to ensure it’s safe for your specific circumstances.

Drug to Drug Interactions

Certain medications may interact with Chenodeoxycholic Acid, potentially altering its effectiveness or increasing side effects. These include:

• Clofibrate (Atromid-S)
• Estrogens (Premarin, Estrace)
• Birth control pills (ethinyl estradiol)

Always inform your healthcare provider or one of our telemedicine professionals about all the medications you’re taking, including over-the-counter drugs and supplements.

Chenodeoxycholic Acid in Pregnancy

Chenodeoxycholic Acid is classified as a category C drug for pregnancy. This means there are no well-controlled studies in humans, but potential benefits may warrant its use in pregnant women despite potential risks. Always discuss medication use during pregnancy with your healthcare provider or one of our telemedicine professionals.

Chenodeoxycholic Acid while Breastfeeding

There is limited information on the safety of Chenodeoxycholic Acid during breastfeeding. Therefore, always consult your healthcare provider or one of our telemedicine professionals before using this medication while breastfeeding.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Chenodeoxycholic Acid (250mg) without insurance, using a GoodRx coupon, is approximately $80-$120. Prices may vary based on the pharmacy and location.

Possible Alternatives

For each condition, there are alternative treatments or lifestyle changes that might help:

• Gallstones: Non-surgical alternatives include adopting a low-cholesterol diet and losing weight gradually. Another medication option could be Ursodeoxycholic Acid (Urso).
• Cerebrotendinous Xanthomatosis (CTX): Lifestyle modifications, such as maintaining a healthy weight and regular physical activity, may help manage symptoms. However, there are no known medication alternatives to Chenodeoxycholic Acid for CTX.

Always discuss these alternatives with your healthcare provider or one of our telemedicine professionals before making any changes to your treatment plan.

Recent Updates on Chenodeoxycholic Acid Research

Recent research into Chenodeoxycholic Acid shows promising results in the treatment of metabolic and neurological disorders beyond its conventional uses. However, more research is needed to confirm these potential benefits and their implications for patients. Remember, while emerging research can be promising, it’s essential to consult with your healthcare provider or one of our telemedicine professionals before making any changes to your treatment regimen based on new studies.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.