Pylera (Bismuth Subcitrate Potassium/Metronidazole/Tetracycline Hydrochloride)

Names of Medication

Pylera is the brand name for a combination medication that contains Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Hydrochloride.

Pharmacologic Category

This medication belongs to the pharmacologic category of antibiotics and bismuth salts. Other medications in this category include other antibiotics like amoxicillin, and bismuth-containing medications like bismuth subsalicylate (Pepto-Bismol).

Dosing

Helicobacter pylori infection

The standard dosage for treating Helicobacter pylori infection in adults is three capsules taken four times daily (after meals and at bedtime) for 10 days. Each capsule contains 140 mg of Bismuth Subcitrate Potassium, 125 mg of Metronidazole, and 125 mg of Tetracycline Hydrochloride.

Peptic Ulcer Disease

Pylera is used in combination with omeprazole for the treatment of patients with peptic ulcer disease associated with H. pylori infection. The standard dosage is the same as for H. pylori infection.
Always remember to take this medication exactly as prescribed by your healthcare provider. Do not adjust the dosage without your doctor’s advice.

Dosage Forms and Strengths

Pylera is available in capsule form. Each capsule contains Bismuth Subcitrate Potassium 140 mg, Metronidazole 125 mg, and Tetracycline Hydrochloride 125 mg.

Administration Instructions

Pylera capsules should be swallowed whole with a full glass of water (8 ounces). They should not be chewed or broken. The medication is usually taken four times daily, after meals and at bedtime, for 10 days.

Adverse Reactions and Side Effects

Common side effects of Pylera include: 1. Nausea (Common): Nausea is a feeling of discomfort or unease in the stomach. It is likely due to the effect of metronidazole and tetracycline on the stomach lining. 2. Diarrhea (Common): Diarrhea is frequent loose or watery bowel movements. It can occur due to the disruption of the normal bacterial flora in the gut caused by antibiotics. 3. Abdominal Pain (Common): This can be due to the irritation of the stomach lining by the medication. 4. Dysgeusia (Common): This is a condition in which a foul, salty, rancid, or metallic taste sensation persists in the mouth. It can occur due to the presence of bismuth subcitrate potassium.

Contraindications to Taking Pylera

A contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Contraindications for Pylera include:
Allergy to bismuth subcitrate, metronidazole, or tetracycline: If you have a known
allergy to any component of this medication, taking it could lead to a serious allergic reaction.
Renal Impairment: Metronidazole and tetracycline are both substantially excreted by the kidney, and the risk of adverse reactions may be greater in patients with impaired renal function.

Pregnant and breastfeeding women:
Tetracycline, a component of Pylera, can have harmful effects on the development of the fetus and can be excreted into breast milk.

Drug to Drug Interactions

Pylera can interact with certain other medications, including:
Anticoagulants like Warfarin (Coumadin): Metronidazole has been reported to potentiate the anticoagulant effect of warfarin, leading to an increased risk of bleeding.
Alcohol: Consumption of alcohol should be avoided during and for at least three days after therapy with Pylera due to the possibility of a disulfiram-like (antabuse effect) reaction.
Antacids, Multivitamins, and Dairy Products: These can interfere with the absorption of tetracycline, reducing its effectiveness.

Bismuth Subcitrate Potassium/Metronidazole/Tetracycline Hydrochloride in Pregnancy

Pylera is categorized as a Class D drug for pregnancy. This means there is positive evidence of human fetal risk, but the potential benefits may warrant use in pregnant women despite potential risks. It’s important to discuss the risks and benefits with your healthcare provider.

Bismuth Subcitrate Potassium/Metronidazole/Tetracycline Hydrochloride While Breastfeeding

Tetracycline, a component of Pylera, is excreted into breast milk and could affect the bone and tooth development of a breastfeeding infant. Therefore, it is generally not recommended for nursing mothers.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Pylera, without insurance and utilizing a GoodRx coupon, is approximately $500 – $600. However, prices may vary depending on the pharmacy, location, and potential changes in negotiated agreements between pharmacies and pharmaceutical companies.

Brief Legal Disclaimer:
This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

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Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.