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Torsemide (Demadex) – Uses, Dosage, Side Effects, and More

US Brand Name (Generic Name):

Demadex ({Torsemide})

Pharmacologic category:

{Loop diuretic}. Other medications in this category include {Furosemide} (Lasix), {Bumetanide} (Bumex), and {Ethacrynic acid} (Edecrin).

Diseases Treated, Dosing, and Treatment Duration

{Edema} (fluid retention) associated with {congestive heart failure}: Initial dose of 10-20 mg daily, depending on the severity of the condition; may be adjusted based on response.
{Edema} associated with {liver cirrhosis}: Initial dose of 5-10 mg daily, adjusted based on response.
{Edema} associated with {kidney disease} ({nephrotic syndrome}): Initial dose of 10-20 mg daily, adjusted based on response.
{Acute pulmonary edema}: Initial dose of 20 mg daily, adjusted based on response.
{Hypertension} (high blood pressure): Initial dose of 5 mg daily, may be increased to 10 mg daily if needed.
{Ascites}: Dosing depends on the severity and underlying cause; consult a healthcare provider for individualized recommendations.

Dosage Forms and strengths:

Tablet: 5 mg, 10 mg, 20 mg, and 100 mg.

Administration Instructions:

Usually once daily. It can be taken with or without food. It’s best to take it in the morning to avoid nighttime urination.

Adverse Reactions and Side Effects:

{Dizziness} (3-10%): A sensation of lightheadedness or feeling faint. {Headache} (2-8%): Pain or discomfort in the head or neck region. {Nausea} (1-5%): An unpleasant sensation in the stomach, often accompanied by an urge to vomit. {Constipation} (1-5%): Infrequent or difficult bowel movements. {Diarrhea} (1-5%): Frequent and watery bowel movements. {Hyperuricemia} (1-5%): Elevated levels of uric acid in the blood, which can lead to {gout} or {kidney stones}.

Contraindications:

It should not be used in patients with a known allergy to {torsemide} or {sulfonylureas}, or in patients with {anuria} (complete absence of urine).

Drug to Drug Interactions:

{Digoxin} (Lanoxin): Increased risk of digoxin toxicity. {Lithium} (Eskalith, Lithobid): Decreased lithium clearance and increased risk of lithium toxicity. {Aminoglycosides} (e.g., {Gentamicin}, {Tobramycin}): Increased risk of hearing loss or kidney damage. {Nonsteroidal anti-inflammatory drugs (NSAIDs)} (e.g., {Ibuprofen}, {Naproxen}): Reduced diuretic effect of {torsemide} and increased risk of kidney damage.

Pregnancy:

{Torsemide} is classified as pregnancy category B. It should only be used during pregnancy if the potential benefits outweigh the risks.

Breastfeeding:

{Torsemide} is excreted in breast milk. Due to the potential for adverse effects in nursing infants, a decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Estimated price of a 30-day supply:

The estimated price of a 30-day supply of {Torsemide} 20 mg, assuming the patient doesn’t have insurance and is utilizing a GoodRx coupon, is approximately $10-$20. Prices may vary depending on the pharmacy, dosage, and location.

Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

Torsemide (Demadex) – Uses, Dosage, Side Effects, and More

US Brand Name (Generic Name):

Demadex ({Torsemide})

Pharmacologic category:

{Loop diuretic}. Other medications in this category include {Furosemide} (Lasix), {Bumetanide} (Bumex), and {Ethacrynic acid} (Edecrin).

Diseases Treated, Dosing, and Treatment Duration

{Edema} (fluid retention) associated with {congestive heart failure}: Initial dose of 10-20 mg daily, depending on the severity of the condition; may be adjusted based on response.
{Edema} associated with {liver cirrhosis}: Initial dose of 5-10 mg daily, adjusted based on response.
{Edema} associated with {kidney disease} ({nephrotic syndrome}): Initial dose of 10-20 mg daily, adjusted based on response.
{Acute pulmonary edema}: Initial dose of 20 mg daily, adjusted based on response.
{Hypertension} (high blood pressure): Initial dose of 5 mg daily, may be increased to 10 mg daily if needed.
{Ascites}: Dosing depends on the severity and underlying cause; consult a healthcare provider for individualized recommendations.

Dosage Forms and strengths:

Tablet: 5 mg, 10 mg, 20 mg, and 100 mg.

Administration Instructions:

Usually once daily. It can be taken with or without food. It’s best to take it in the morning to avoid nighttime urination.

Adverse Reactions and Side Effects:

{Dizziness} (3-10%): A sensation of lightheadedness or feeling faint. {Headache} (2-8%): Pain or discomfort in the head or neck region. {Nausea} (1-5%): An unpleasant sensation in the stomach, often accompanied by an urge to vomit. {Constipation} (1-5%): Infrequent or difficult bowel movements. {Diarrhea} (1-5%): Frequent and watery bowel movements. {Hyperuricemia} (1-5%): Elevated levels of uric acid in the blood, which can lead to {gout} or {kidney stones}.

Contraindications:

It should not be used in patients with a known allergy to {torsemide} or {sulfonylureas}, or in patients with {anuria} (complete absence of urine).

Drug to Drug Interactions:

{Digoxin} (Lanoxin): Increased risk of digoxin toxicity. {Lithium} (Eskalith, Lithobid): Decreased lithium clearance and increased risk of lithium toxicity. {Aminoglycosides} (e.g., {Gentamicin}, {Tobramycin}): Increased risk of hearing loss or kidney damage. {Nonsteroidal anti-inflammatory drugs (NSAIDs)} (e.g., {Ibuprofen}, {Naproxen}): Reduced diuretic effect of {torsemide} and increased risk of kidney damage.

Pregnancy:

{Torsemide} is classified as pregnancy category B. It should only be used during pregnancy if the potential benefits outweigh the risks.

Breastfeeding:

{Torsemide} is excreted in breast milk. Due to the potential for adverse effects in nursing infants, a decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Estimated price of a 30-day supply:

The estimated price of a 30-day supply of {Torsemide} 20 mg, assuming the patient doesn’t have insurance and is utilizing a GoodRx coupon, is approximately $10-$20. Prices may vary depending on the pharmacy, dosage, and location.

Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

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