US Brand Name (Generic Name):

TNKase ({Tenecteplase})

Pharmacologic category:

Tissue Plasminogen Activator (tPA)
Other medications in the same pharmacologic category: {Alteplase} (Activase), {Reteplase} (Retavase)

Diseases Treated, Dosing, and Treatment Duration

{Acute Myocardial Infarction} (AMI): {Tenecteplase} is used as a single bolus intravenous injection. The dose is weight-based, with a maximum of 50 mg. Treatment should be initiated as soon as possible after the onset of AMI symptoms.

Dosage Forms and Strengths:

Lyophilized powder for injection: 50 mg vials

Administration Instructions:

Reconstitute the lyophilized powder with sterile water for injection, then administer as a single intravenous bolus injection over 5 seconds.

Adverse Reactions and Side Effects:

{Dizziness} (5-12%): A sensation of lightheadedness or feeling faint, which may increase the risk of falls.
{Headache} (3-10%): Pain or discomfort in the head or neck region.
{Cough} (1-10%): A dry, persistent cough resulting from the medication’s effect on the lungs.
{Hypotension} (1-5%): Low blood pressure, which can cause dizziness, lightheadedness, and fainting.
{Hyperkalemia} (1-5%): Elevated potassium levels in the blood, which can cause irregular heartbeats or other heart-related issues.
{Angioedema} (less than 1%): Swelling of the face, lips, tongue, or throat, which can cause difficulty breathing and requires immediate medical attention.

Contraindications:

Active internal bleeding
Recent intracranial or intraspinal surgery or trauma
Intracranial neoplasm, arteriovenous malformation, or aneurysm
Severe uncontrolled hypertension
Hypersensitivity to {Tenecteplase} or any of its components

Drug to Drug Interactions:

Anticoagulants (e.g., {Warfarin} [Coumadin], {Heparin})
Antiplatelet agents (e.g., {Aspirin}, {Clopidogrel} [Plavix])
Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., {Ibuprofen} [Advil, Motrin], {Naproxen} [Aleve])

Pregnancy:

There is limited data on the use of {Tenecteplase} during pregnancy. Consult with a healthcare provider to weigh the potential benefits and risks of using {Tenecteplase} during pregnancy.

Breastfeeding:

It is not known if {Tenecteplase} is excreted in human milk. Consult with a healthcare provider to weigh the potential benefits and risks of using {Tenect eplase} while breastfeeding.

Cost Estimate:

Since {Tenecteplase} is administered as a single-dose treatment in a hospital setting for {acute myocardial infarction}, a 30-day supply is not applicable. The cost of {Tenecteplase} depends on factors such as hospital fees and negotiated drug prices. The cost for a single 50 mg vial can range from $2,000 to $3,000. Patients are encouraged to consult with their healthcare provider and insurance company to determine their out-of-pocket expenses.

Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.