US Brand Name: Repatha (Evolocumab)

Pharmacologic Category: Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) Inhibitor

Other medications in this category: {Alirocumab} (Praluent)

Diseases Treated, Dosing, and Treatment Duration:

{Heterozygous familial hypercholesterolemia (HeFH)}: 140 mg every 2 weeks or 420 mg once monthly
{Homozygous familial hypercholesterolemia (HoFH)}: 420 mg once monthly
{Clinical atherosclerotic cardiovascular disease (ASCVD)} requiring additional lowering of LDL cholesterol: 140 mg every 2 weeks or 420 mg once monthly

Dosage Forms and Strengths:

Single-use prefilled syringe: 140 mg/mL Single-use prefilled SureClick autoinjector: 140 mg/mL Single-use Pushtronex system (on-body infusor with prefilled cartridge): 420 mg/mL

Administration Instructions:

Administer as a subcutaneous injection into the thigh, abdomen, or upper arm. Rotate injection sites. If using the 420 mg dose, administer it as 3 consecutive injections at different sites within 30 minutes.

Adverse Reactions and Side Effects:

{Injection site reactions} (redness, swelling, pain) (common) {Upper respiratory tract infection} (common) {Back pain} (common) {Influenza-like symptoms} (less common) {Allergic reactions}, including rash and hives (rare)

Contraindications:

Hypersensitivity to {evolocumab} or any of its components.

Drug to Drug Interactions:

No significant drug interactions have been reported with {evolocumab}. However, it is essential to inform your healthcare provider of all medications you are taking, including prescription, over-the-counter, and herbal products.

Pregnancy:

There is limited data on the use of {evolocumab} during pregnancy. Consult your healthcare provider before using this medication if you are pregnant or planning to become pregnant.

Breastfeeding:

It is unknown if {evolocumab} passes into breast milk. Consult your healthcare provider before using this medication if you are breastfeeding.

Estimated Price for a 30-Day Supply:

Prices may vary depending on the dosage and location, but the estimated cost for a 30-day supply of {evolocumab} using a GoodRx coupon ranges from $450 to $600.

Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.