US Brand Name (Generic Name): Praluent (alirocumab)

Pharmacologic Category: PCSK9 inhibitor

Other medications in the same category include: {Evolocumab} (Repatha)

Diseases Treated and Dosing Information:

{Heterozygous familial hypercholesterolemia (HeFH)}: Initial dose is 75 mg every 2 weeks; can be increased to 150 mg every 2 weeks if needed for additional LDL cholesterol reduction.
{Homozygous familial hypercholesterolemia (HoFH)}: Initial dose is 150 mg every 2 weeks.
{Clinical atherosclerotic cardiovascular disease (ASCVD)} requiring additional lowering of LDL cholesterol: Initial dose is 75 mg every 2 weeks; can be increased to 150 mg every 2 weeks if needed for additional LDL cholesterol reduction.

Dosage Forms and Strengths:

Single-use prefilled syringe: 75 mg/mL Single-use prefilled syringe: 150 mg/mL Single-use prefilled pen: 75 mg/mL Single-use prefilled pen: 150 mg/mL

Administration Instructions:

Administer as a subcutaneous injection in the thigh, abdomen, or upper arm. Rotate injection sites. Do not inject into areas that are tender, bruised, red, or hard.

Adverse Reactions and Side Effects:

{Injection site reactions} (very common): Pain, redness, or swelling at the injection site. {Upper respiratory tract infection} (common): Cold-like symptoms, such as a runny nose or sore throat. {Allergic reactions} (rare): Rash, itching, or swelling of the face, lips, tongue, or throat.

Contraindications:

Hypersensitivity to {alirocumab} or any of its excipients.

Drug to Drug Interactions:

{Warfarin} (Coumadin, Jantoven): {Alirocumab} may increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding.

Pregnancy:

There is limited data on the use of {alirocumab} in pregnant women. Consult a healthcare provider before using this medication during pregnancy.

Breastfeeding:

It is not known if {alirocumab} is present in human milk. Consult a healthcare provider before using this medication while breastfeeding.

Estimated Price for a 30-Day Supply without Insurance Using a GoodRx Coupon:

The price may vary depending on the dosage and location, but it is generally around $450 to $600 for a 30-day supply. Please check GoodRx for the most accurate and
up-to-date pricing information.

Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.