Vernakalant Medication: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Vernakalant is a prescription medication used to treat specific heart rhythm disorders, particularly atrial fibrillation. It works by stabilizing the heart’s electrical activity, helping to restore a normal rhythm. Vernakalant is typically administered in a hospital setting under close medical supervision. Always consult your healthcare provider before starting or adjusting your treatment. Our telemedicine providers are available to help you manage your heart health.

Names of Medication

US Brand Name: Brinavess

Generic Name: Vernakalant

The generic name refers to the official medical name of the active ingredient in the medication. It is listed in parentheses after the brand name.

Pharmacologic Category

Antiarrhythmic Agent, Class III

Other medications in this category include Amiodarone, Dronedarone, and Sotalol.

Vernakalant Dosing

Vernakalant is used to treat various heart rhythm disorders in adults. The dosing and frequency depend on the specific condition being treated. Always consult your doctor before adjusting your dose. Our telemedicine providers can assist you with any concerns about your treatment.

Atrial Fibrillation (AFib)

Vernakalant is typically administered as an intravenous (IV) infusion. The initial dose is 3 mg/kg over 10 minutes. If the heart rhythm does not return to normal, a second dose of 2 mg/kg may be given after 15 minutes. This treatment is usually provided in a hospital setting.

Atrial Flutter

Vernakalant may be used off-label for atrial flutter. The dosing is similar to that for atrial fibrillation, but always consult your healthcare provider for specific guidance.

Supraventricular Tachycardia (SVT)

Vernakalant is not commonly used for SVT, but in some cases, it may be considered. The dosing would be determined by your healthcare provider.

Paroxysmal Atrial Fibrillation

For patients with paroxysmal atrial fibrillation, Vernakalant is administered as an IV infusion. The initial dose is 3 mg/kg over 10 minutes, with a second dose of 2 mg/kg if needed after 15 minutes.

Persistent Atrial Fibrillation

Vernakalant is used to convert persistent atrial fibrillation to a normal heart rhythm. The dosing is the same as for paroxysmal atrial fibrillation.

Cardiac Arrhythmias

Vernakalant is used to treat certain types of cardiac arrhythmias, particularly those related to atrial fibrillation. The dosing is similar to that for atrial fibrillation.

Tachyarrhythmias

Vernakalant may be used in some cases of tachyarrhythmias, but the dosing will depend on the specific type of arrhythmia. Consult your healthcare provider for details.

Heart Rhythm Disorders

Vernakalant is primarily used for atrial fibrillation but may be considered for other heart rhythm disorders. Always follow your doctor’s instructions.

Ventricular Tachycardia

Vernakalant is not typically used for ventricular tachycardia. Other medications are usually preferred for this condition.

Dosage Forms and Strengths

Vernakalant is available as an intravenous (IV) solution for infusion.

Strength: 20 mg/mL in 10 mL or 25 mL vials.

Administration Instructions

Vernakalant is administered by a healthcare professional, usually in a hospital setting. It is given as an intravenous (IV) infusion over 10 minutes. If needed, a second dose may be administered 15 minutes after the first. You will be closely monitored during and after the infusion to ensure your heart rhythm returns to normal and to watch for any side effects. Vernakalant is not a medication you take at home.

Adverse Reactions and Side Effects

Like all medications, Vernakalant can cause side effects. Some are more common, while others are rare but serious. If you experience any side effects, contact your healthcare provider immediately. You can also speak with one of our telemedicine providers for guidance.

Common Side Effects

These occur in more than 1 in 10 patients.

1. Taste disturbances: A metallic or bitter taste in the mouth is common during or after the infusion.
2. Nausea: Some patients may feel nauseous during or after treatment.

Less Common Side Effects

These occur in 1 in 100 to 1 in 1,000 patients.

1. Hypotension (low blood pressure): Some patients may experience a drop in blood pressure during the infusion.
2. Dizziness: Feeling lightheaded or dizzy may occur, especially if blood pressure drops.

Rare but Serious Side Effects

These occur in less than 1 in 1,000 patients.

1. Severe allergic reactions: Signs include swelling of the face, lips, or throat, difficulty breathing, and hives. Seek emergency medical attention if this occurs.
2. Worsening heart rhythm problems: In rare cases, Vernakalant can cause new or worsening arrhythmias. Your healthcare provider will monitor you closely to prevent this.

Contraindications

A contraindication is a specific situation or condition where a medication should not be used because it may be harmful to the patient. Vernakalant, like many medications, has certain contraindications that must be considered before starting treatment. If you have any of the following conditions, Vernakalant may not be safe for you:

1. Severe Aortic Stenosis: Vernakalant is contraindicated in patients with severe aortic stenosis because it can increase the risk of dangerous heart complications in people with this condition.
2. Hypotension (Low Blood Pressure): If you have low blood pressure, Vernakalant can cause it to drop even further, leading to dizziness, fainting, or more serious complications.
3. Acute Coronary Syndrome: This includes conditions like a recent heart attack or unstable angina. Vernakalant is not recommended in these cases because it may worsen heart function or increase the risk of arrhythmias.
4. Severe Heart Failure: Vernakalant is contraindicated in patients with severe heart failure, as it could exacerbate the condition and lead to worsening heart function.
5. Prolonged QT Interval: If you have a condition that causes a prolonged QT interval (a type of abnormal heart rhythm), Vernakalant may increase the risk of life-threatening arrhythmias.

If you have any of these conditions, it’s important to talk to your healthcare provider before starting Vernakalant. Our telemedicine providers are available to discuss your medical history and help determine the safest treatment options for you.

Drug to Drug Interactions

Vernakalant can interact with other medications, potentially increasing side effects or reducing its effectiveness. It’s crucial to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Some medications that may interact with Vernakalant include:

1. Antiarrhythmic drugs: Medications such as amiodarone (Pacerone), sotalol (Betapace), and quinidine can increase the risk of dangerous heart rhythms when used alongside Vernakalant.
2. Beta-blockers: Drugs like metoprolol (Lopressor) and propranolol (Inderal) may raise the risk of bradycardia (a slow heart rate) when taken with Vernakalant.
3. Calcium channel blockers: Medications such as verapamil (Calan) and diltiazem (Cardizem) may increase the likelihood of low blood pressure when combined with Vernakalant.
4. Drugs that prolong the QT interval: Medications like erythromycin (Ery-Tab) and certain antipsychotics (e.g., haloperidol) can heighten the risk of serious arrhythmias when taken with Vernakalant.

Always consult your healthcare provider before starting or stopping any medications. If you’re unsure about potential interactions, our telemedicine providers can review your current medications to ensure Vernakalant is safe for you.

Vernakalant in Pregnancy

Is Vernakalant safe during pregnancy? The safety of Vernakalant during pregnancy has not been thoroughly studied. It is classified as a Category C drug, meaning animal studies have shown some risk to the fetus, but there are no well-controlled studies in humans. If you are pregnant or planning to become pregnant, it’s important to carefully weigh the potential risks and benefits. Discuss your options with your healthcare provider to determine the best treatment plan for you.

Vernakalant while Breastfeeding

Is Vernakalant safe while breastfeeding? There is limited information on whether Vernakalant passes into breast milk. Due to the lack of data, caution is advised when taking Vernakalant while breastfeeding. Be sure to discuss the risks and benefits with your healthcare provider to determine the best course of action for both you and your baby.

Estimated Cost of Vernakalant Medication

The cost of a 30-day supply of Vernakalant without insurance can vary depending on the pharmacy and location. With a GoodRx coupon, the price typically ranges from $300 to $500. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a prescription discount service like GoodRx to find the best available price.

Possible Alternatives to Vernakalant

If Vernakalant is not suitable for you, there are other treatment options available for managing heart rhythm disorders. These alternatives may include medications, lifestyle changes, or procedures. Always discuss any changes to your treatment plan with your healthcare provider. Below are some possible alternatives for specific conditions:

1. Atrial Fibrillation & Atrial Flutter: Medications such as amiodarone (Pacerone) or beta-blockers (e.g., metoprolol) may be used. In some cases, procedures like electrical cardioversion or catheter ablation may be recommended. Lifestyle changes, such as reducing alcohol intake, managing stress, and maintaining a healthy weight, can also help.
2. Supraventricular Tachycardia (SVT): Medications like adenosine (Adenocard) or calcium channel blockers (e.g., verapamil) may be used. Vagal maneuvers (such as holding your breath and bearing down) can sometimes stop an SVT episode. In some cases, catheter ablation may be considered.
3. Paroxysmal Atrial Fibrillation: Medications such as flecainide (Tambocor) or sotalol (Betapace) may help control heart rhythm. Lifestyle changes, including avoiding triggers like caffeine or alcohol, can also help manage symptoms.
4. Persistent Atrial Fibrillation: Medications like dofetilide (Tikosyn) or dronedarone (Multaq) may be used. In some cases, catheter ablation may be recommended to restore normal heart rhythm.
5. Cardiac Arrhythmias & Tachyarrhythmias: Beta-blockers (e.g., propranolol) or calcium channel blockers (e.g., diltiazem) may be used. In some cases, an implantable device like a pacemaker or defibrillator may be recommended.
6. Ventricular Tachycardia: Medications such as amiodarone (Pacerone) or lidocaine may help control heart rhythm. In some cases, an implantable cardioverter-defibrillator (ICD) may be necessary to prevent life-threatening arrhythmias.

Work closely with your healthcare provider to determine the best treatment plan for your specific condition. If you’re considering alternatives to Vernakalant, our telemedicine providers are available to discuss your options and guide you through the decision-making process.

Recent Updates on Vernakalant Research

Recent studies on Vernakalant have focused on its effectiveness in treating atrial fibrillation and its potential use in other heart rhythm disorders. A 2022 study published in the Journal of Cardiovascular Electrophysiology found that Vernakalant was effective in converting recent-onset atrial fibrillation to normal sinus rhythm in most patients. Additionally, ongoing research is exploring the use of Vernakalant in combination with other antiarrhythmic drugs to improve outcomes in patients with persistent atrial fibrillation.

While Vernakalant shows promise, it’s important to stay informed about new research and discuss any updates with your healthcare provider. Our telemedicine providers are available to help you understand the latest developments and how they may impact your treatment plan.

James Kingsley

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