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Valbenazine Medication: Uses, Dosage & Side Effects Guide
Key Points About Valbenazine Medication
Valbenazine is a prescription medication primarily used to manage movement disorders, particularly tardive dyskinesia. It works by regulating specific brain chemicals that control movement. While most individuals tolerate Valbenazine well, some may experience side effects such as drowsiness or fatigue. It is essential to follow your healthcare provider’s instructions closely when taking this medication. If you have any questions or concerns, consider consulting one of our telemedicine providers for personalized advice.
Names of Valbenazine Medication
US Brand Name: Ingrezza (Valbenazine)
The generic name, Valbenazine, refers to the active ingredient in the medication, while the brand name, Ingrezza, is the name given by the manufacturer.
Pharmacologic Category of Valbenazine
Valbenazine belongs to a class of medications known as Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors. This classification reflects how the medication works to manage movement disorders like tardive dyskinesia by targeting specific pathways in the brain.
Valbenazine Dosage Guidelines
Valbenazine is approved by the FDA for the treatment of tardive dyskinesia in adults. Below are the recommended dosages for this condition. Always consult your healthcare provider before making any changes to your dosage or starting a new treatment. You can also schedule a telemedicine appointment with one of our providers for expert guidance.
Valbenazine Dosage for Tardive Dyskinesia
Initial dose: 40 mg taken orally once daily
Maintenance dose: After one week, increase to 80 mg taken orally once daily
Duration: Long-term treatment as directed by your healthcare provider
Off-Label Uses of Valbenazine
At this time, Valbenazine is not FDA-approved for conditions such as schizophrenia, bipolar disorder, major depressive disorder, Parkinson’s disease, Huntington’s disease, Tourette syndrome, autism spectrum disorder, anxiety disorders, or obsessive-compulsive disorder. However, healthcare providers may discuss potential off-label uses based on individual needs. Speak with your doctor or one of our telemedicine providers to learn more.
Dosage Forms and Strengths of Valbenazine
Valbenazine is available in capsule form in the following strengths:
- 40 mg
- 60 mg
- 80 mg
How to Take Valbenazine
Valbenazine is typically taken once daily, with or without food. Swallow the capsule whole—do not crush, chew, or break it. To ensure consistent levels of the medication in your body, take it at the same time each day. If you miss a dose, take it as soon as you remember unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Avoid taking two doses at the same time.
Valbenazine Side Effects and Adverse Reactions
Like all medications, Valbenazine may cause side effects. While not everyone experiences them, it is important to be aware of potential reactions. If you notice severe side effects, contact your healthcare provider immediately. You can also reach out to one of our telemedicine providers for support.
Common Valbenazine Side Effects (1-10% of Patients)
- Drowsiness: Feeling unusually sleepy or lethargic
- Fatigue: A general sense of tiredness or reduced energy levels
- Dry mouth: A decrease in saliva production, leading to a dry sensation in the mouth
Less Common Valbenazine Side Effects (Less Than 1% of Patients)
- Changes in heart rhythm (QT prolongation): A rare but potentially serious condition affecting the heart’s electrical activity
- Restlessness: An unusual feeling of agitation or inability to remain still
- Depression: Worsening mood or increased feelings of sadness
Contraindications for Valbenazine
A contraindication refers to a specific condition or circumstance in which a medication should not be used because it may cause harm. It is essential to understand these contraindications before starting a new medication like Valbenazine.
Valbenazine is contraindicated in the following situations:
Hypersensitivity to Valbenazine or its ingredients: If you have ever experienced an allergic reaction to Valbenazine or any of its components, taking this medication could trigger severe allergic responses. Symptoms may include rash, swelling, or difficulty breathing, which require immediate medical attention.
Severe liver impairment: Valbenazine is processed by the liver, and impaired liver function can interfere with the body’s ability to metabolize the drug. This may lead to higher levels of the medication in your system, increasing the risk of side effects.
If you suspect you have any of these conditions, it is important to consult your healthcare provider before beginning Valbenazine treatment for movement disorders. You can also schedule a telemedicine appointment with one of our providers to discuss your options and ensure this medication is safe for you.
Drug-to-Drug Interactions with Valbenazine
Valbenazine may interact with other medications, potentially increasing side effects or reducing the effectiveness of either Valbenazine or the other drugs. To minimize risks, inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs, vitamins, and supplements. Below are some examples of medications that may interact with Valbenazine:
- Strong CYP3A4 inhibitors: These medications can increase Valbenazine levels in the body, raising the likelihood of side effects. Examples include:
- Ketoconazole (Nizoral)
- Clarithromycin (Biaxin)
- Strong CYP3A4 inducers: These drugs can decrease Valbenazine levels, potentially reducing its effectiveness. Examples include:
- Rifampin (Rifadin)
- Carbamazepine (Tegretol)
- MAO inhibitors (MAOIs): Combining MAOIs with Valbenazine can increase the risk of serious side effects. Examples include:
- Phenelzine (Nardil)
- Tranylcypromine (Parnate)
Always consult your healthcare provider before starting or stopping any medications. If you are unsure about potential interactions, you can speak with one of our telemedicine providers to review your current medications and ensure that Valbenazine treatment is appropriate for you.
Valbenazine and Pregnancy
Is it safe to take Valbenazine during pregnancy?
The safety of Valbenazine during pregnancy has not been fully established. Limited data is available on its use in pregnant women, and animal studies suggest there may be potential risks to the developing fetus. As a result, Valbenazine should only be used during pregnancy if the potential benefits clearly outweigh the risks. If you are pregnant or planning to become pregnant, it is crucial to discuss this with your healthcare provider to make an informed decision.
Valbenazine While Breastfeeding
Is it safe to take Valbenazine while breastfeeding?
It is not yet known whether Valbenazine passes into breast milk. Due to the possibility of serious side effects in nursing infants, breastfeeding mothers are generally advised to either discontinue the medication or stop breastfeeding. If you are currently breastfeeding or planning to breastfeed, consult your healthcare provider to carefully weigh the risks and benefits of using Valbenazine for movement disorders.
Estimated Cost of Valbenazine Medication
The cost of a 30-day supply of Valbenazine without insurance can be significant. With a GoodRx coupon, the estimated price ranges from $5,000 to $6,000 for a 40 mg dosage. Prices may vary depending on the pharmacy and location. If you are paying out of pocket, consider exploring available discounts or patient assistance programs that may help reduce the cost of treatment.
Possible Alternatives to Valbenazine
If Valbenazine is not the right fit for your treatment, there are other options and lifestyle adjustments that may help manage your condition. It’s important to consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these alternatives in detail.
Tardive Dyskinesia: Alternatives include deutetrabenazine (Austedo) or transitioning to an antipsychotic medication with a lower risk of causing tardive dyskinesia. Additionally, physical therapy and relaxation techniques, such as deep breathing or yoga, may help ease symptoms.
Schizophrenia: Other antipsychotic medications, such as aripiprazole (Abilify) or olanzapine (Zyprexa), may provide effective symptom management. Complementary approaches, including cognitive behavioral therapy (CBT) and lifestyle modifications like stress reduction and maintaining a nutritious diet, can further enhance treatment outcomes.
Bipolar Disorder: Common alternatives include mood stabilizers like lithium or anticonvulsants such as valproate (Depakote). Psychotherapy, along with establishing a consistent sleep routine, can also play a significant role in managing symptoms effectively.
Major Depressive Disorder: Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), are often prescribed. Incorporating regular physical activity, mindfulness practices, and therapy can also help alleviate symptoms of depression.
Parkinson’s Disease: Medications like levodopa or dopamine agonists are commonly used to manage symptoms. Engaging in physical therapy and maintaining a regular exercise routine can improve mobility and reduce stiffness associated with the condition.
Huntington’s Disease: Tetrabenazine (Xenazine) may help control involuntary movements. Speech therapy and occupational therapy can further enhance the quality of life for individuals living with Huntington’s disease.
Tourette Syndrome: Antipsychotic medications such as risperidone (Risperdal) or behavioral therapy may help manage tics. Stress management techniques and relaxation exercises can also provide additional support.
Autism Spectrum Disorder: Behavioral, speech, and occupational therapies are commonly used to support developmental progress. In some cases, medications may be prescribed to address specific symptoms, such as irritability or hyperactivity.
Anxiety Disorders: Treatment options may include SSRIs or benzodiazepines. Cognitive behavioral therapy (CBT) and mindfulness-based practices are also effective in reducing anxiety symptoms and improving overall well-being.
Obsessive-Compulsive Disorder (OCD): SSRIs, such as fluoxetine (Prozac) or clomipramine (Anafranil), are frequently prescribed. Exposure and response prevention (ERP) therapy, a specialized form of CBT, is a highly effective non-medication approach for managing OCD.
Recent Updates on Valbenazine Research
Recent studies have explored the long-term safety and effectiveness of Valbenazine for treating tardive dyskinesia. A 2022 study published in the Journal of Clinical Psychopharmacology demonstrated that Valbenazine significantly reduces involuntary movements over a 48-week period, with side effects that are generally manageable. Additionally, ongoing research is investigating its potential use for other movement disorders, such as Tourette syndrome and Huntington’s disease. However, further clinical trials are necessary to confirm its efficacy for these conditions.
As new research continues to emerge, staying informed about the latest findings is essential. Be sure to discuss any updates and their potential impact on your treatment plan with one of our telemedicine providers.
