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Urofollitropin: Essential Guide for Fertility Treatment Success
Summary of Key Points
Urofollitropin is a fertility medication used to stimulate the ovaries in women and enhance sperm production in men. It is commonly prescribed for conditions such as infertility, polycystic ovary syndrome (PCOS), and hypogonadism. Urofollitropin works by promoting egg development in women and supporting sperm production in men. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine providers are available to assist you with any questions or concerns.
Names of Medication
US Brand Name: Bravelle
Generic Name: Urofollitropin
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.
Pharmacologic Category
Gonadotropin
Follicle-Stimulating Hormone (FSH)
Urofollitropin Dosage Guidelines
Urofollitropin is used to treat a variety of fertility and reproductive health conditions. The dosage and frequency of administration depend on the specific condition being treated. Always follow your doctor’s instructions carefully, and consult with one of our telemedicine providers before making any changes to your prescribed dose.
Infertility (Female)
Dosage: 150 IU to 225 IU injected subcutaneously or intramuscularly once daily.
Frequency: Administer once daily, starting on day 2 or 3 of the menstrual cycle.
Length of Treatment: Continue until adequate follicular development is achieved, typically between 7 and 12 days.
Polycystic Ovary Syndrome (PCOS)
Dosage: 75 IU to 150 IU injected subcutaneously or intramuscularly once daily.
Frequency: Administer once daily, starting on day 2 or 3 of the menstrual cycle.
Length of Treatment: Continue until adequate follicular development is achieved, typically between 7 and 12 days.
Hypogonadism (Male)
Dosage: 150 IU to 225 IU injected subcutaneously or intramuscularly three times per week.
Frequency: Administer three times per week.
Length of Treatment: Treatment may last several months, depending on the individual’s response.
Ovarian Dysfunction
Dosage: 75 IU to 150 IU injected subcutaneously or intramuscularly once daily.
Frequency: Administer once daily, starting on day 2 or 3 of the menstrual cycle.
Length of Treatment: Continue until adequate follicular development is achieved, typically between 7 and 12 days.
Anovulation
Dosage: 75 IU to 150 IU injected subcutaneously or intramuscularly once daily.
Frequency: Administer once daily, starting on day 2 or 3 of the menstrual cycle.
Length of Treatment: Continue until adequate follicular development is achieved, typically between 7 and 12 days.
Male Hypogonadism
Dosage: 150 IU to 225 IU injected subcutaneously or intramuscularly three times per week.
Frequency: Administer three times per week.
Length of Treatment: Treatment may last several months, depending on the individual’s response.
Testicular Failure
Dosage: 150 IU to 225 IU injected subcutaneously or intramuscularly three times per week.
Frequency: Administer three times per week.
Length of Treatment: Treatment may last several months, depending on the individual’s response.
Ovulatory Disorders
Dosage: 75 IU to 150 IU injected subcutaneously or intramuscularly once daily.
Frequency: Administer once daily, starting on day 2 or 3 of the menstrual cycle.
Length of Treatment: Continue until adequate follicular development is achieved, typically between 7 and 12 days.
Assisted Reproductive Technology (ART)
Dosage: 150 IU to 225 IU injected subcutaneously or intramuscularly once daily.
Frequency: Administer once daily, starting on day 2 or 3 of the menstrual cycle.
Length of Treatment: Continue until adequate follicular development is achieved, typically between 7 and 12 days.
Follicle Stimulation (Female)
Dosage: 75 IU to 150 IU injected subcutaneously or intramuscularly once daily.
Frequency: Administer once daily, starting on day 2 or 3 of the menstrual cycle.
Length of Treatment: Continue until adequate follicular development is achieved, typically between 7 and 12 days.
Dosage Forms and Strengths
Urofollitropin for injection is available in the following strengths:
- 75 IU per vial
- 150 IU per vial
Contraindications for Urofollitropin
A contraindication is a condition in which a medication should not be used because it may cause harm. If you have any of the following conditions, Urofollitropin may not be safe for you. Always discuss your medical history with your healthcare provider before starting any new medication.
Primary Ovarian Failure: Urofollitropin is ineffective in individuals with primary ovarian failure, a condition where the ovaries no longer function properly. In such cases, the medication will not stimulate the ovaries as intended.
Uncontrolled Thyroid or Adrenal Dysfunction: Hormonal imbalances related to the thyroid or adrenal glands can interfere with Urofollitropin’s effectiveness and may exacerbate these conditions.
Abnormal Uterine Bleeding: If you have unexplained uterine bleeding, Urofollitropin should not be used until the cause is identified, as it could mask or worsen underlying conditions.
Ovarian Cysts or Enlargement: Urofollitropin can further enlarge the ovaries, potentially leading to complications such as ovarian torsion or rupture.
Pregnancy: Urofollitropin is not intended for use during pregnancy, as it stimulates ovulation. Once pregnancy is confirmed, the medication should be discontinued.
Hypersensitivity to Urofollitropin: If you have had an allergic reaction to Urofollitropin or similar medications, you should not take this medication, as it could cause severe allergic reactions.
Drug to Drug Interactions
It’s crucial to inform your healthcare provider about all medications you are currently taking, as some drugs may interact with Urofollitropin. These interactions can either reduce the effectiveness of your fertility treatment or increase the risk of side effects.
Clomiphene (Clomid): Clomiphene is another fertility medication used to stimulate ovulation. When combined with Urofollitropin, it may elevate the risk of ovarian hyperstimulation syndrome (OHSS).
Gonadorelin (Factrel): Gonadorelin is a hormone used to assess pituitary function. Using it alongside Urofollitropin may alter hormone levels and potentially affect the success of fertility treatments.
Human Chorionic Gonadotropin (hCG, Pregnyl): hCG is often administered with Urofollitropin to trigger ovulation. However, incorrect timing or dosage can increase the likelihood of OHSS or multiple pregnancies.
Urofollitropin in Pregnancy
Is it safe to take Urofollitropin when pregnant?
No, Urofollitropin is not safe during pregnancy. This medication is designed to stimulate ovulation, and once pregnancy is achieved, it should be discontinued. Continuing Urofollitropin during pregnancy could lead to complications. If you suspect you are pregnant while taking Urofollitropin, contact your healthcare provider immediately.
Urofollitropin while Breastfeeding
Is it safe to take Urofollitropin while breastfeeding?
There is limited information on whether Urofollitropin passes into breast milk or how it might affect a breastfeeding infant. Due to the lack of data, it’s generally recommended to avoid using Urofollitropin while breastfeeding unless specifically advised by your healthcare provider. If you are breastfeeding and considering fertility treatments, discuss your options with your provider.
Estimated Cost of Urofollitropin
The cost of Urofollitropin can vary depending on your location and pharmacy. Without insurance, the estimated cost for a 30-day supply of Urofollitropin using a GoodRx coupon ranges from approximately $1,000 to $2,000. Prices may fluctuate, so it’s advisable to check with your pharmacy or use a prescription discount service like GoodRx for the most accurate pricing.
Possible Alternatives to Urofollitropin
If Urofollitropin is not the right option for you, several alternative treatments and lifestyle changes may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these options.
- Infertility: Alternatives include Clomiphene (Clomid), Letrozole (Femara), or In Vitro Fertilization (IVF). Lifestyle changes such as maintaining a healthy weight, reducing stress, and avoiding smoking and alcohol can also improve fertility.
- Polycystic Ovary Syndrome (PCOS): Metformin (Glucophage) or hormonal birth control can help manage PCOS symptoms. Lifestyle changes like weight loss, regular exercise, and a balanced diet may also improve ovulation and fertility.
- Hypogonadism: Testosterone replacement therapy or medications like Clomiphene can treat hypogonadism. Lifestyle changes such as reducing alcohol intake and managing stress may also help balance hormone levels.
- Ovarian Dysfunction: Hormone replacement therapy (HRT) or other fertility medications may be alternatives. Your provider may also recommend lifestyle changes like improving diet and exercise habits.
- Anovulation: Medications like Clomiphene or Letrozole can help stimulate ovulation. Maintaining a healthy weight and managing stress can also improve ovulation.
- Male Hypogonadism: Testosterone replacement therapy or medications like hCG may be used. Lifestyle changes such as weight loss, regular exercise, and reducing alcohol consumption can also help.
- Testicular Failure: Treatment options include hormone replacement therapy or assisted reproductive technologies like sperm donation. Lifestyle changes such as avoiding smoking and reducing stress may also support overall health.
- Ovulatory Disorders: Medications like Clomiphene or Letrozole may be used to stimulate ovulation. Maintaining a healthy weight and reducing stress can also improve ovulatory function.
- Assisted Reproductive Technology (ART): IVF, Intracytoplasmic Sperm Injection (ICSI), or donor eggs/sperm may be alternatives. Your provider can help you determine the best ART option for your situation.
- Follicle Stimulation: Other medications like Follitropin Alfa (Gonal-F) or Follitropin Beta (Follistim) may be used as alternatives to Urofollitropin for follicle stimulation.
Recent Updates on Urofollitropin Research
Recent research on Urofollitropin has focused on enhancing its effectiveness in assisted reproductive technologies (ART) and reducing the risk of ovarian hyperstimulation syndrome (OHSS). Studies suggest that individualized dosing protocols, tailored to a patient’s ovarian reserve and hormone levels, may improve outcomes and minimize complications. Additionally, ongoing research is exploring the use of Urofollitropin in combination with other fertility medications to optimize treatment success while reducing side effects.
As new studies emerge, it’s important to stay informed about the latest developments in fertility treatments. If you have questions about how recent research may impact your treatment plan, our telemedicine providers are available to discuss the latest options with you.
