Tranexamic Acid: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Tranexamic acid is a medication used to prevent or reduce bleeding in various conditions, including heavy menstrual bleeding, hemophilia, and trauma-related bleeding. It works by helping the blood clot more effectively. Tranexamic acid is available in different forms and strengths, with the dosage depending on the condition being treated. Always consult a healthcare provider before starting or adjusting your dose.

Names of Medication

US Brand Name: Lysteda (Tranexamic acid)

The generic name is the official medical name for a drug, while the brand name is given by the manufacturer. The generic name is listed in parentheses.

Pharmacologic Category

Antifibrinolytic Agent

Hemostatic Agent

Tranexamic Acid Dosage

Tranexamic acid is prescribed for various conditions, with the dosage varying based on the specific indication. Always follow your doctor’s instructions and consult them before making any changes to your dose. Our telemedicine providers are available to assist with any concerns.

Tranexamic Acid for Heavy Menstrual Bleeding (Menorrhagia)

Dosage: 1,300 mg orally three times a day during menstruation.

Duration: Up to 5 days during each menstrual cycle.

Tranexamic Acid for Hemophilia (Dental Procedures)

Dosage: 25 mg/kg orally or intravenously, 2 to 3 times a day.

Duration: Start before the procedure and continue for 2 to 8 days.

Tranexamic Acid in Surgery (Postoperative Bleeding)

Dosage: 10 mg/kg intravenously before surgery, then every 6 to 8 hours for 2 to 8 days.

Tranexamic Acid for Trauma-Related Bleeding

Dosage: 1 gram intravenously over 10 minutes, followed by another 1 gram over 8 hours.

Tranexamic Acid for Uterine Fibroids

Dosage: 1,300 mg orally three times a day during menstruation.

Duration: Up to 5 days during each menstrual cycle.

Tranexamic Acid for Thrombocytopenic Purpura

Dosage: 25 mg/kg orally or intravenously, 2 to 3 times a day.

Duration: Continue as prescribed by your healthcare provider.

Tranexamic Acid for Liver Disease-Related Bleeding

Dosage: 10 mg/kg intravenously every 6 to 8 hours.

Duration: As needed, based on your doctor’s recommendation.

Tranexamic Acid for Nosebleeds (Epistaxis)

Dosage: 25 mg/kg orally or intravenously, 2 to 3 times a day.

Duration: Continue as prescribed by your healthcare provider.

Dosage Forms and Strengths

Oral Tablets: 650 mg, 1,300 mg

Intravenous (IV) Solution: 100 mg/mL

Administration Instructions

Tranexamic acid can be taken orally or administered intravenously, depending on the condition being treated. If taking oral tablets, swallow them whole with water. Do not crush or chew the tablets. If receiving the medication through an IV, it will be administered by a healthcare professional. Always follow your doctor’s instructions carefully, and reach out to our telemedicine providers if you have any questions.

Contraindications for Tranexamic Acid

A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. If you have any of the following conditions, Tranexamic acid may not be safe for you:

1. Active or history of blood clots (thrombosis): Tranexamic acid prevents the breakdown of blood clots. If you have a history of blood clots, this medication could increase the risk of dangerous clots forming in your veins or arteries.
2. Subarachnoid hemorrhage: This is a type of bleeding in the brain. Taking Tranexamic acid in this condition could increase the risk of complications, such as stroke or brain damage.
3. Severe kidney disease: Tranexamic acid is processed by the kidneys. If your kidneys are not functioning properly, the drug could build up in your system, leading to harmful side effects.
4. Hypersensitivity to Tranexamic acid: If you are allergic to Tranexamic acid, taking this medication could cause an allergic reaction, including symptoms like rash, swelling, or difficulty breathing.

Always discuss your full medical history with your healthcare provider before starting Tranexamic acid, especially if you have any of these conditions. If you have concerns, schedule a telemedicine appointment with one of our providers for personalized advice.

Drug to Drug Interactions

Tranexamic acid can interact with other medications, increasing the risk of side effects or reducing treatment effectiveness. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Some medications that may interact with Tranexamic acid include:

1. Hormonal contraceptives (e.g., ethinyl estradiol): Using Tranexamic acid with birth control pills can increase the risk of blood clots.
2. Factor IX complex (e.g., Bebulin, Profilnine): These medications, used to treat hemophilia, may increase the risk of clotting when taken with Tranexamic acid.
3. Tretinoin (e.g., Vesanoid): This medication, used for certain types of cancer, may increase the risk of blood clots when combined with Tranexamic acid.
4. Desmopressin (e.g., DDAVP): This medication, used to treat bleeding disorders, may increase the risk of clotting when taken with Tranexamic acid.

If you are taking any of these medications, talk to your healthcare provider before starting Tranexamic acid. Our telemedicine providers are available to help review your medications and ensure your treatment plan is safe and effective.

Tranexamic Acid in Pregnancy

Is it safe to take Tranexamic acid during pregnancy?

Tranexamic acid is classified as a pregnancy category B drug by the FDA. This means that while animal studies have not shown harm to the fetus, there are no well-controlled studies in pregnant women. Tranexamic acid may be prescribed during pregnancy to manage bleeding disorders, but only under the close supervision of a healthcare provider. If you are pregnant or planning to become pregnant, it is important to consult your doctor before taking Tranexamic acid. Our telemedicine providers are available to help you weigh the potential risks and benefits of using this medication during pregnancy.

Tranexamic Acid while Breastfeeding

Is it safe to take Tranexamic acid while breastfeeding?

Tranexamic acid passes into breast milk in small amounts. While it is generally considered safe for short-term use during breastfeeding, it is crucial to discuss this with your healthcare provider. They can help you determine whether the benefits of taking Tranexamic acid outweigh any potential risks to your baby. If you have concerns about breastfeeding while using Tranexamic acid, our telemedicine providers are here to offer personalized guidance.

Estimated Cost of Tranexamic Acid

The cost of a 30-day supply of Tranexamic acid without insurance can vary. However, with a GoodRX coupon, the estimated price typically ranges from $50 to $100, depending on the pharmacy and dosage. Be sure to explore available coupons or discounts to help lower your out-of-pocket costs.

Possible Alternatives to Tranexamic Acid

Depending on the condition being treated, there may be alternative treatments or lifestyle changes that can help manage your symptoms. Always consult your healthcare provider before making any changes to your treatment plan. Below are some alternatives for specific conditions:

1. Heavy menstrual bleeding: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, hormonal therapies (e.g., birth control pills), or an intrauterine device (IUD) that releases progestin may be considered.
2. Hemophilia: Factor replacement therapy or desmopressin may be used to manage bleeding episodes.
3. Postoperative bleeding: Compression garments, advanced surgical techniques, or other medications like desmopressin may be alternatives.
4. Trauma-related bleeding: Blood transfusions, surgical interventions, or other clotting agents may be necessary, depending on the severity of the injury.
5. Dental procedures in hemophilia: Factor replacement therapy or antifibrinolytic agents other than Tranexamic acid may be used to prevent bleeding.
6. Uterine fibroids: Hormonal treatments, such as GnRH agonists, or surgical options like myomectomy may be considered.
7. Thrombocytopenic purpura: Treatments may include corticosteroids, immunoglobulins, or, in severe cases, splenectomy.
8. Liver disease-related bleeding: Vitamin K supplementation, blood transfusions, or other clotting agents may be options.
9. Menorrhagia: Hormonal treatments, such as birth control pills or an IUD, may help reduce heavy menstrual bleeding.
10. Epistaxis (nosebleeds): Nasal sprays, cauterization, or nasal packing may be used to control bleeding.

If you are considering any of these alternatives, it is essential to discuss them with your healthcare provider. You can schedule a telemedicine appointment with one of our providers to explore your options and find the best treatment for your needs.

Recent Updates on Tranexamic Acid Research

Recent studies have examined the use of Tranexamic acid in various medical settings. One area of ongoing research is its role in trauma-related bleeding, where it has been shown to reduce mortality in patients with severe bleeding when administered early. Additionally, researchers are investigating its potential to reduce blood loss during major surgeries, such as joint replacements and cardiac procedures. There is also growing interest in its use for managing bleeding in patients with liver disease, though more studies are needed to confirm its safety and effectiveness in this population.

As research continues, new findings may expand the clinical applications of Tranexamic acid. If you have questions about the latest research or how it may impact your treatment, our telemedicine providers are available to help you stay informed and make the best decisions for your health.

James Kingsley

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