Ticarcillin Clavulanic Acid: Uses, Dosage, and Side Effects

Summary or Key Points

Ticarcillin/clavulanic acid is a combination antibiotic used to treat serious bacterial infections, including pneumonia, urinary tract infections, and skin infections. This medication works by both stopping bacterial growth and preventing resistance to treatment. Always take this medication exactly as prescribed by your healthcare provider. If you have any questions or concerns, feel free to consult one of our telemedicine providers today.

Names of Medication

US Brand Name: Timentin

Generic Name: Ticarcillin/clavulanic acid

The generic name refers to the official medical name of the active ingredients in the medication. It is typically listed in parentheses.

Pharmacologic Category

Penicillin Antibiotic

Beta-lactamase Inhibitor Combination

Ticarcillin Clavulanic Acid Dosing

Ticarcillin/clavulanic acid is prescribed for a variety of bacterial infections. The dosage depends on the specific condition being treated. Always follow your healthcare provider’s instructions carefully, and never adjust your dose without consulting them first. If you need to speak with a provider, we offer telemedicine consultations for your convenience.

Pneumonia: 3.1 grams (3g ticarcillin/0.1g clavulanic acid) every 4-6 hours for 7-14 days, depending on the severity of the infection.

Urinary Tract Infection (UTI): 3.1 grams every 4-6 hours for 7-10 days.

Skin and Soft Tissue Infections: 3.1 grams every 4-6 hours for 7-14 days.

Intra-abdominal Infections: 3.1 grams every 4-6 hours for 7-14 days.

Bone and Joint Infections: 3.1 grams every 4-6 hours for 4-6 weeks, depending on the severity and response to treatment.

Sepsis: 3.1 grams every 4-6 hours for 10-14 days, or longer depending on the severity of the condition.

Endocarditis: 3.1 grams every 4-6 hours for 4-6 weeks, depending on the severity and response to treatment.

Respiratory Tract Infections: 3.1 grams every 4-6 hours for 7-14 days.

Bacteremia: 3.1 grams every 4-6 hours for 10-14 days, or longer depending on the severity of the infection.

Meningitis: 3.1 grams every 4-6 hours for 10-14 days.

Dosage Forms and Strengths

Injection, powder for reconstitution: 3.1 grams (3g ticarcillin/0.1g clavulanic acid) per vial

Administration Instructions for Ticarcillin Clavulanic Acid

Ticarcillin/clavulanic acid is administered through intravenous (IV) infusion, typically in a hospital or clinical setting. It is important to follow your healthcare provider’s instructions carefully. If you are receiving this treatment at home, ensure that you or your caregiver are properly trained to administer the IV infusion. Always complete the full course of antibiotics, even if you start feeling better, to prevent the infection from returning or becoming resistant to treatment.

Ticarcillin Clavulanic Acid Side Effects and Adverse Reactions

Like all medications, ticarcillin/clavulanic acid can cause side effects. While most are mild, some may be more serious. If you experience severe symptoms, contact your healthcare provider immediately. You can also schedule a telemedicine appointment for further guidance.

Common Side Effects (1-10%):

1. Nausea and vomiting: Mild nausea or vomiting may occur.
2. Diarrhea: Loose stools are a common side effect of antibiotics.
3. Rash: A mild skin rash may develop, which could indicate an allergic reaction.

Less Common Side Effects (<1%):

1. Severe allergic reactions (anaphylaxis): A rare but serious reaction that can cause difficulty breathing, swelling of the face, lips, or throat, and requires immediate medical attention.
2. Clostridium difficile-associated diarrhea (C. diff): A rare but serious form of diarrhea that may require additional treatment.
3. Liver dysfunction: Some patients may experience changes in liver function, which can be detected through blood tests.

Contraindications for Ticarcillin Clavulanic Acid

A contraindication is a specific condition where a medication should not be used because it may cause harm. It’s important to know if you have any of these conditions before starting a new medication. Below are the contraindications for ticarcillin/clavulanic acid:

Allergy to penicillins or beta-lactam antibiotics: Ticarcillin is a penicillin-type antibiotic, and clavulanic acid is a beta-lactamase inhibitor. If you are allergic to penicillin or other beta-lactam antibiotics (such as amoxicillin or cephalosporins), taking this medication could cause a severe allergic reaction, including anaphylaxis.

Severe kidney disease: Ticarcillin/clavulanic acid is processed by the kidneys. If your kidneys are not functioning properly, the medication may build up in your body, leading to toxicity. Your doctor may need to adjust the dose or choose an alternative treatment.

History of cholestatic jaundice or liver dysfunction associated with penicillin use: If you’ve experienced liver problems or jaundice (yellowing of the skin or eyes) after taking penicillin-based antibiotics, you should avoid ticarcillin/clavulanic acid, as it may worsen liver function.

Drug to Drug Interactions

Understanding potential drug interactions is essential when taking Ticarcillin/clavulanic acid. Below are some medications that may interact with this antibiotic combination:

1. Probenecid (Probalan): This medication can increase the levels of Ticarcillin/clavulanic acid in your blood, which may lead to toxicity.
2. Warfarin (Coumadin): Taking Ticarcillin/clavulanic acid with warfarin may heighten the risk of bleeding. Your doctor may need to monitor your blood clotting levels more frequently.
3. Methotrexate (Trexall):Ticarcillin/clavulanic acid can raise methotrexate levels in your body, increasing the likelihood of side effects or toxicity.
4. Oral contraceptives (birth control pills): Antibiotics like Ticarcillin/clavulanic acid may reduce the effectiveness of birth control pills, increasing the risk of unintended pregnancy. Consider using an additional form of contraception while on this medication.

Ticarcillin/clavulanic acid in Pregnancy

Is it Safe to Take Ticarcillin/clavulanic acid During Pregnancy?

Ticarcillin/clavulanic acid is classified as a Category B medication for pregnancy by the FDA. This means that animal studies have not shown harm to the fetus, but there are no well-controlled studies in pregnant women. While this antibiotic combination may be used during pregnancy if clearly necessary, it’s important to discuss the potential risks and benefits with your healthcare provider. If you are pregnant or planning to become pregnant, consult one of our telemedicine providers to determine if this medication is appropriate for you.

Ticarcillin/clavulanic acid While Breastfeeding

Is it Safe to Take Ticarcillin/clavulanic acid While Breastfeeding?

Ticarcillin/clavulanic acid is generally considered safe during breastfeeding. Although small amounts may pass into breast milk, it is unlikely to harm a nursing infant. However, some infants may experience mild gastrointestinal symptoms, such as diarrhea or thrush. If you are breastfeeding, it’s advisable to discuss this with your healthcare provider before starting the medication. You can also consult one of our telemedicine providers for personalized advice.

Estimated Cost of Ticarcillin/clavulanic acid

The cost of a 30-day supply of Ticarcillin/clavulanic acid without insurance can vary. With a GoodRX coupon, the estimated cost ranges from $100 to $150. Prices may differ depending on the pharmacy and location. Be sure to check with your local pharmacy or use a prescription savings program to find the best price.

Possible Alternatives to Ticarcillin/clavulanic acid

If Ticarcillin/clavulanic acid is not suitable for you, alternative treatments and lifestyle changes may help manage your condition. Always discuss these options with your healthcare provider before making any changes to your treatment plan. You can also speak to one of our telemedicine providers for guidance.

1. Pneumonia: Alternatives include antibiotics such as azithromycin (Zithromax) or levofloxacin (Levaquin). Lifestyle changes, like quitting smoking and getting vaccinated against pneumonia, may also help prevent future infections.
2. Urinary tract infection (UTI): Common alternatives include trimethoprim/sulfamethoxazole (Bactrim) or nitrofurantoin (Macrobid). Drinking plenty of water and practicing good hygiene can help prevent UTIs.
3. Skin and soft tissue infections: Cephalexin (Keflex) or clindamycin (Cleocin) may be used as alternatives. Keeping wounds clean and dry can help prevent infections.
4. Intra-abdominal infections: Metronidazole (Flagyl) or ciprofloxacin (Cipro) may be considered. Maintaining a healthy diet and avoiding foods that irritate the digestive system can help manage symptoms.
5. Bone and joint infections: Vancomycin or linezolid (Zyvox) may be considered. Physical therapy and maintaining a healthy weight can support joint health.
6. Sepsis: Broad-spectrum antibiotics like meropenem (Merrem) or piperacillin/tazobactam (Zosyn) are often used. Early detection and treatment are critical for managing sepsis.
7. Endocarditis: Vancomycin or gentamicin may be used as alternatives. Good dental hygiene and regular check-ups can help prevent endocarditis.
8. Respiratory tract infections: Alternatives include doxycycline or amoxicillin/clavulanic acid (Augmentin). Avoiding allergens and practicing good hand hygiene can help prevent infections.
9. Bacteremia: Ceftriaxone (Rocephin) or vancomycin may be used as alternatives. Early treatment of infections can help prevent bacteremia.
10. Meningitis: Ceftriaxone (Rocephin) or ampicillin may be used as alternatives. Vaccinations can help prevent certain types of meningitis.

Recent Updates on Ticarcillin/clavulanic acid Research

Recent studies have focused on the effectiveness of Ticarcillin/clavulanic acid in treating multi-drug resistant infections, particularly in hospital settings. Researchers are exploring its use in combination with other antibiotics to combat resistant bacteria like Pseudomonas aeruginosa. While Ticarcillin/clavulanic acid remains a valuable option for certain infections, ongoing research aims to optimize its use and reduce the risk of resistance. If you have concerns about antibiotic resistance or the latest treatment options, consult one of our telemedicine providers for up-to-date advice.

James Kingsley

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