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Talazoparib: Comprehensive Cancer Treatment & Dosage Guide
Summary of Key Points
Talazoparib is a prescription medication used to treat certain types of cancer, including breast and ovarian cancer. It works by targeting cancer cells and preventing them from repairing themselves, which helps slow or stop tumor growth. Talazoparib is taken orally, and it’s important to follow your doctor’s instructions carefully. Side effects may occur, so be sure to discuss any concerns with your healthcare provider.
Names of Medication
US Brand Name: Talzenna (Talazoparib)
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.
Pharmacologic Category
PARP Inhibitors (Poly ADP-Ribose Polymerase Inhibitors)
Talazoparib Dosage and Treatment Guidelines
Talazoparib is prescribed to treat various cancers in adults. The dosage and duration of treatment depend on the specific type of cancer. Always consult your healthcare provider before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers to discuss your treatment plan.
Talazoparib for Breast Cancer
Indication: For adults with HER2-negative breast cancer with a BRCA mutation.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Ovarian Cancer
Indication: For adults with BRCA-mutated ovarian cancer.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Prostate Cancer
Indication: For adults with metastatic castration-resistant prostate cancer (mCRPC) with BRCA mutations.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Pancreatic Cancer
Indication: For adults with BRCA-mutated pancreatic cancer.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Gastric Cancer
Indication: For adults with BRCA-mutated gastric cancer.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Colorectal Cancer
Indication: For adults with BRCA-mutated colorectal cancer.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Lung Cancer
Indication: For adults with BRCA-mutated lung cancer.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Endometrial Cancer
Indication: For adults with BRCA-mutated endometrial cancer.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Urothelial Carcinoma
Indication: For adults with BRCA-mutated urothelial carcinoma.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Talazoparib for Fallopian Tube Cancer
Indication: For adults with BRCA-mutated fallopian tube cancer.
Dosage: 1 mg orally once daily.
Length of Treatment: Continue until disease progression or unacceptable toxicity.
Dosage Forms and Strengths
Capsules: 0.25 mg, 1 mg
Administration Instructions for Talazoparib
Talazoparib is taken orally, typically once a day. Swallow the capsule whole with water; do not crush, chew, or open it. You can take it with or without food. If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. Do not take two doses at once. Always follow your doctor’s instructions carefully.
Contraindications for Talazoparib Therapy
A contraindication is a specific condition or situation where a drug should not be used because it may cause harm. If you have any of the following conditions, Talazoparib may not be safe for you. Always consult your healthcare provider before starting or stopping any medication.
Hypersensitivity to Talazoparib: If you have had an allergic reaction to Talazoparib or any of its ingredients, you should not take this medication. Symptoms of an allergic reaction may include rash, itching, swelling, or difficulty breathing.
Severe Renal Impairment: Talazoparib is processed by the kidneys. If you have severe kidney problems, the drug may not be cleared from your body properly, increasing the risk of side effects.
Pregnancy: Talazoparib can harm an unborn baby. It is contraindicated during pregnancy due to the risk of birth defects or miscarriage.
Breastfeeding: Talazoparib may pass into breast milk and could harm a nursing infant. It is contraindicated for women who are breastfeeding.
Drug-to-Drug Interactions with Talazoparib
Talazoparib can interact with other medications, potentially increasing side effects or reducing the effectiveness of either Talazoparib or the other drug. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs, supplements, and herbal products.
Carbamazepine (Tegretol): This anti-seizure medication can reduce Talazoparib’s effectiveness by speeding up its breakdown in the body.
Phenytoin (Dilantin): Another anti-seizure drug that may lower Talazoparib levels, making it less effective.
Rifampin (Rifadin): An antibiotic used to treat tuberculosis, Rifampin can decrease Talazoparib levels, reducing its effectiveness.
St. John’s Wort: This herbal supplement, often used for depression, can reduce Talazoparib’s effectiveness by increasing its breakdown in the liver.
Talazoparib in Pregnancy
Is it Safe to Take Talazoparib During Pregnancy?
No, Talazoparib is not considered safe during pregnancy. This PARP inhibitor can cause harm to an unborn baby, potentially leading to birth defects or miscarriage. If you are pregnant or planning to become pregnant, it is important to avoid taking Talazoparib. Women of childbearing potential should use effective contraception during treatment and for at least seven months after the final dose. If you become pregnant while taking Talazoparib, contact your healthcare provider immediately for guidance.
Talazoparib While Breastfeeding
Is it Safe to Take Talazoparib While Breastfeeding?
No, Talazoparib is not recommended for women who are breastfeeding. The medication may pass into breast milk and could potentially harm a nursing infant. If you are currently breastfeeding or planning to breastfeed, consult your healthcare provider to discuss alternative treatments or feeding options during your Talazoparib therapy.
Estimated Cost of Talazoparib Medication
The cost of Talazoparib can vary depending on your location and pharmacy. Without insurance, a 30-day supply of Talazoparib (1 mg capsules) is estimated to range between $16,000 and $17,000. However, with a GoodRx coupon, the price may be reduced to around $14,000. It is advisable to check with your pharmacy and explore financial assistance programs that may help manage the cost of Talazoparib treatment.
Possible Alternatives to Talazoparib
If Talazoparib is not suitable for you, there may be other treatment options available depending on your specific type of cancer. It is essential to discuss any potential changes in treatment with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to receive personalized advice on alternatives to Talazoparib.
Breast Cancer
For breast cancer, alternatives to Talazoparib may include other PARP inhibitors such as Olaparib (Lynparza) or chemotherapy options like Doxorubicin (Adriamycin). Hormonal therapies, such as Tamoxifen, may also be considered for certain types of breast cancer.
Ovarian Cancer
In the case of ovarian cancer, alternatives may include other PARP inhibitors like Niraparib (Zejula) or chemotherapy regimens such as Carboplatin and Paclitaxel.
Prostate Cancer
For prostate cancer, hormonal therapies such as Abiraterone (Zytiga) or Enzalutamide (Xtandi) may be considered. Chemotherapy options like Docetaxel (Taxotere) are also available as alternatives to Talazoparib.
Pancreatic Cancer
For pancreatic cancer, chemotherapy regimens such as FOLFIRINOX (a combination of several drugs) or Gemcitabine (Gemzar) may be used as alternatives to Talazoparib.
Gastric Cancer
In the treatment of gastric cancer, chemotherapy options like 5-Fluorouracil (5-FU) or targeted therapies such as Trastuzumab (Herceptin) may be considered as alternatives to Talazoparib.
Colorectal Cancer
For colorectal cancer, alternatives to Talazoparib may include chemotherapy regimens such as FOLFOX or targeted therapies like Bevacizumab (Avastin).
Lung Cancer
In lung cancer treatment, immunotherapy options such as Pembrolizumab (Keytruda) or chemotherapy regimens like Cisplatin and Pemetrexed may be considered as alternatives to Talazoparib.
Endometrial Cancer
For endometrial cancer, hormonal therapies such as Progestins or chemotherapy options like Carboplatin and Paclitaxel may be used as alternatives to Talazoparib.
Urothelial Carcinoma
In the treatment of urothelial carcinoma, immunotherapy drugs like Atezolizumab (Tecentriq) or chemotherapy regimens such as Gemcitabine and Cisplatin may be considered as alternatives to Talazoparib.
Fallopian Tube Cancer
Similar to ovarian cancer, alternatives for fallopian tube cancer may include chemotherapy options like Carboplatin and Paclitaxel or other PARP inhibitors such as Olaparib (Lynparza).
Recent Updates on Talazoparib Research
Recent studies have shown promising results for Talazoparib when used in combination with other therapies. Ongoing clinical trials are exploring its use alongside immunotherapy drugs like Avelumab (Bavencio) for advanced breast cancer. Additionally, research is investigating Talazoparib’s effectiveness in cancers beyond breast and ovarian, such as prostate and pancreatic cancers. These studies aim to broaden Talazoparib’s application to a wider range of cancers, potentially offering new treatment options for patients.
As research continues to evolve, we will update this page with the latest findings. Be sure to discuss any new developments with your healthcare provider, and consider scheduling a telemedicine visit with one of our providers to explore how these updates may impact your Talazoparib treatment plan.
