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Streptokinase: Uses, Dosage, and Side Effects Overview
Summary of Key Points
Streptokinase is a medication used to dissolve blood clots in conditions such as heart attacks, strokes, and blood clots in the lungs or legs. It works by breaking down proteins that cause clots to form. This medication is typically administered in a hospital setting under close supervision. Always consult your healthcare provider before starting or adjusting treatment. You can also speak with one of our telemedicine providers for more information.
Names of Medication
US Brand Name: Streptase (Streptokinase)
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this case, Streptokinase is the generic name.
Pharmacologic Category
Streptokinase belongs to the Thrombolytic Agents category, which includes other clot-dissolving medications such as:
- Alteplase (Activase)
- Reteplase (Retavase)
- Tenecteplase (TNKase)
Streptokinase Dosage
Streptokinase is used to treat various conditions related to blood clots. The dosage depends on the specific condition being treated. Always follow your healthcare provider’s instructions and never adjust your dose without consulting them. If you have any questions, our telemedicine providers are available to assist you.
Streptokinase for Myocardial Infarction (Heart Attack)
Dose: 1.5 million units IV (intravenous) over 60 minutes
Frequency: Single dose
Length of Treatment: One-time administration
Streptokinase for Pulmonary Embolism (Blood Clot in the Lungs)
Dose: 250,000 units IV over 30 minutes, followed by 100,000 units per hour for 24-72 hours
Frequency: Continuous infusion
Length of Treatment: 24-72 hours
Streptokinase for Deep Vein Thrombosis (DVT)
Dose: 250,000 units IV over 30 minutes, followed by 100,000 units per hour for 24-72 hours
Frequency: Continuous infusion
Length of Treatment: 24-72 hours
Streptokinase for Arterial Thrombosis
Dose: 250,000 units IV over 30 minutes, followed by 100,000 units per hour for 24-72 hours
Frequency: Continuous infusion
Length of Treatment: 24-72 hours
Streptokinase for Ischemic Stroke
Dose: 1.5 million units IV over 60 minutes
Frequency: Single dose
Length of Treatment: One-time administration
Streptokinase for Peripheral Artery Occlusion
Dose: 250,000 units IV over 30 minutes, followed by 100,000 units per hour for 24-72 hours
Frequency: Continuous infusion
Length of Treatment: 24-72 hours
Streptokinase for Coronary Artery Thrombosis
Dose: 1.5 million units IV over 60 minutes
Frequency: Single dose
Length of Treatment: One-time administration
Streptokinase for Thrombotic Stroke
Dose: 1.5 million units IV over 60 minutes
Frequency: Single dose
Length of Treatment: One-time administration
Streptokinase for Acute Coronary Syndrome
Dose: 1.5 million units IV over 60 minutes
Frequency: Single dose
Length of Treatment: One-time administration
Dosage Forms and Strengths
Streptokinase is available in the following forms:
- Injection, powder for solution: 250,000 units, 750,000 units, 1.5 million units
Streptokinase Administration Guidelines
Streptokinase is administered through an intravenous (IV) line, typically in a hospital setting by a healthcare professional. The dose is carefully monitored to ensure safety. The medication is infused over a specific period, depending on the condition being treated. Follow all instructions provided by your healthcare team. If you have any questions, contact your doctor or one of our telemedicine providers for guidance.
Contraindications for Streptokinase
A contraindication is a specific situation or condition where a medication should not be used due to potential harm. For Streptokinase, the following conditions make it unsafe:
- Active internal bleeding: Streptokinase breaks down blood clots, so it could worsen existing bleeding.
- Recent surgery or trauma: If you’ve had surgery or a major injury in the last 10 days, Streptokinase could increase the risk of bleeding at the surgical site or injury.
- History of hemorrhagic stroke: If you’ve had a stroke caused by bleeding in the brain, Streptokinase could increase the risk of another bleed.
- Severe uncontrolled high blood pressure: High blood pressure increases the risk of bleeding, and Streptokinase may heighten this risk.
- Recent gastrointestinal bleeding: If you’ve had recent bleeding in your stomach or intestines, Streptokinase could cause further bleeding.
- Known allergy to Streptokinase: If you’ve had an allergic reaction to Streptokinase in the past, avoid this medication to prevent a severe allergic reaction.
Drug-to-Drug Interactions
Streptokinase can interact with other medications, increasing the risk of side effects or reducing treatment effectiveness. Medications that interact with Streptokinase include:
- Anticoagulants (e.g., Warfarin, Coumadin): These blood thinners, when combined with Streptokinase, increase the risk of serious bleeding.
- Antiplatelet drugs (e.g., Aspirin, Plavix [clopidogrel]): These medications prevent blood clots, and using them with Streptokinase can raise the risk of bleeding.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., Ibuprofen, Advil, Motrin): NSAIDs can increase the risk of gastrointestinal bleeding when taken with Streptokinase.
- Heparin: This blood thinner, often used to prevent clots, can increase the risk of bleeding when used with Streptokinase.
Streptokinase in Pregnancy
Is it safe to take Streptokinase when pregnant?
Streptokinase is classified as a Category C drug during pregnancy, meaning there is insufficient research to definitively confirm its safety for pregnant women. While some animal studies have indicated potential risks, no well-controlled studies have been conducted in humans. If you are pregnant or planning to become pregnant, it is essential to discuss the potential risks and benefits of Streptokinase with your healthcare provider. In life-threatening situations, such as a heart attack or stroke, the benefits of treatment may outweigh the possible risks to your baby.
Streptokinase while Breastfeeding
Is it safe to take Streptokinase while breastfeeding?
There is limited information available regarding the safety of Streptokinase during breastfeeding. It is unclear whether the drug passes into breast milk, so caution is advised. If you are breastfeeding, consult your healthcare provider before starting Streptokinase. They will help you weigh the potential risks and benefits to determine the most appropriate course of action for both you and your baby.
Estimated Cost of Streptokinase
The cost of Streptokinase can vary depending on where it is purchased and whether you have insurance coverage. Without insurance, the estimated cost for a 30-day supply using a GoodRX coupon typically ranges from $150 to $300. Prices may fluctuate, so it is advisable to check with your pharmacy for the most accurate and up-to-date pricing information.
Possible Alternatives to Streptokinase
If Streptokinase is not suitable for you, there are several alternative treatments and lifestyle changes that may help manage the conditions it treats. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore your options.
Myocardial Infarction (Heart Attack)
Alternative treatments include other thrombolytic medications such as Alteplase (Activase) or Tenecteplase (TNKase). Additionally, lifestyle changes like quitting smoking, adopting a heart-healthy diet, and engaging in regular physical activity can help reduce the risk of future heart attacks.
Pulmonary Embolism
Other treatment options include anticoagulants such as Heparin or Warfarin. In more severe cases, surgery may be necessary to remove the clot.
Deep Vein Thrombosis (DVT)
Anticoagulants like Rivaroxaban (Xarelto) or Apixaban (Eliquis) are commonly used alternatives. Additionally, wearing compression stockings and maintaining regular physical activity can help prevent DVT.
Arterial Thrombosis
Antiplatelet medications such as Aspirin or Clopidogrel (Plavix) may be prescribed. Managing cholesterol levels and blood pressure through lifestyle modifications can also lower the risk of arterial thrombosis.
Ischemic Stroke
Other thrombolytic drugs, such as Alteplase (Activase), may be used in the treatment of ischemic stroke. Rehabilitation therapies, including physical and speech therapy, are often recommended to aid recovery after a stroke.
Peripheral Artery Occlusion
Treatment options for peripheral artery occlusion include procedures like angioplasty, stenting, or bypass surgery. Regular exercise and a balanced diet can also help improve blood flow.
Coronary Artery Thrombosis
Alternatives include anticoagulants such as Heparin or antiplatelet medications like Aspirin. In some cases, surgical interventions such as angioplasty or coronary artery bypass grafting (CABG) may be required.
Thrombotic Stroke
Other thrombolytic drugs, such as Alteplase (Activase), may be used to treat thrombotic stroke. Stroke rehabilitation, along with lifestyle changes like managing blood pressure and cholesterol, is also crucial for recovery and prevention.
Acute Coronary Syndrome
Treatment options for acute coronary syndrome include antiplatelet medications like Aspirin or Clopidogrel (Plavix), as well as anticoagulants such as Heparin. Lifestyle changes, including quitting smoking and managing stress, can also play a significant role in improving outcomes.
Recent Updates on Streptokinase Research
Recent research on Streptokinase has focused on enhancing its safety and effectiveness. Studies are exploring ways to reduce the risk of bleeding, which is one of the drug’s primary side effects. Researchers are also investigating the potential benefits of combining Streptokinase with other medications to improve its clot-dissolving abilities while minimizing adverse effects.
Additionally, ongoing studies are examining the use of Streptokinase in new patient populations, such as those with less severe clotting disorders. These investigations aim to determine whether Streptokinase can be used more widely in clinical practice.
Staying informed about the latest research is important. Be sure to discuss any new developments with your healthcare provider. If you have questions about whether Streptokinase is the right treatment for you, consider scheduling a telemedicine appointment with one of our providers for personalized guidance.
