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Sodium Ferric Gluconate: Uses, Dosage & Side Effects Guide
Summary or Key Points
Sodium ferric gluconate is an iron supplement used to treat iron deficiency anemia, particularly in individuals with chronic kidney disease or those undergoing hemodialysis. It helps restore iron levels, which are essential for producing healthy red blood cells. This medication is typically administered through an intravenous (IV) infusion. Always consult your healthcare provider before starting or adjusting your dose.
Names of Medication
US Brand Name: Ferrlecit
Generic Name: Sodium ferric gluconate
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.
Pharmacologic Category
Iron Replacement Products
Parenteral Iron Preparations
Dosing
Sodium ferric gluconate is used to treat various types of anemia, especially in patients with iron deficiency. Below are common dosing guidelines for adults:
Iron Deficiency Anemia
Dosage: 125 mg IV infusion over 10 minutes or during dialysis.
Frequency: Typically once a week or as directed by your healthcare provider.
Length of Treatment: Until iron levels normalize, which may take several weeks. Consult your doctor for specific guidance.
Chronic Kidney Disease
Dosage: 125 mg IV infusion during dialysis.
Frequency: Administered during dialysis sessions, usually once a week.
Length of Treatment: Ongoing, depending on iron levels and kidney function. Follow your healthcare provider’s recommendations.
Anemia of Chronic Disease
Dosage: 125 mg IV infusion.
Frequency: Once weekly or as directed.
Length of Treatment: Until anemia improves. Your doctor will monitor your iron levels and adjust treatment as needed.
Hemodialysis-Related Anemia
Dosage: 125 mg IV infusion during dialysis.
Frequency: Typically once per dialysis session.
Length of Treatment: Treatment continues as long as anemia persists. Regular monitoring is required.
Pregnancy-Related Anemia
Dosage: 125 mg IV infusion.
Frequency: Once weekly or as directed.
Length of Treatment: Until iron levels normalize. Consult your healthcare provider for specific guidance during pregnancy.
Malnutrition-Related Anemia
Dosage: 125 mg IV infusion.
Frequency: Once weekly or as directed.
Length of Treatment: Until anemia improves. Your doctor will determine the appropriate duration.
Gastrointestinal Bleeding
Dosage: 125 mg IV infusion.
Frequency: Once weekly or as directed.
Length of Treatment: Until iron levels are restored. Consult your healthcare provider for ongoing management.
Inflammatory Bowel Disease
Dosage: 125 mg IV infusion.
Frequency: Once weekly or as directed.
Length of Treatment: Treatment continues until anemia resolves. Regular monitoring is required.
Cancer-Related Anemia
Dosage: 125 mg IV infusion.
Frequency: Once weekly or as directed.
Length of Treatment: Until iron levels normalize. Consult your healthcare provider for specific guidance.
Post-Surgical Anemia
Dosage: 125 mg IV infusion.
Frequency: Once weekly or as directed.
Length of Treatment: Until anemia resolves. Follow your doctor’s recommendations for ongoing care.
Always consult your healthcare provider before adjusting your dose. If you have questions about your treatment plan, our telemedicine providers are available to assist you.
Dosage Forms and Strengths
Injection, solution: 62.5 mg/5 mL (12.5 mg/mL) in single-use vials
Administration Instructions
Sodium ferric gluconate is administered by a healthcare professional through an intravenous (IV) infusion. It is typically given during dialysis sessions or as part of a regular anemia treatment plan. The infusion is usually slow, lasting around 10 minutes or more, depending on your condition. Inform your healthcare provider of any allergies or reactions to previous iron treatments before starting this medication.
Adverse Reactions and Side Effects
Like all medications, sodium ferric gluconate may cause side effects. While not everyone experiences them, it’s important to be aware of potential reactions. If you notice any severe symptoms, seek medical attention immediately.
Common Side Effects (1-10%): These are mild and often resolve on their own.
- Headache: Mild to moderate headache may occur after the infusion.
- Nausea: Feeling queasy or sick to your stomach.
- Vomiting: Rare, but some patients may experience vomiting post-infusion.
- Low blood pressure: You may feel lightheaded or dizzy during or after the infusion.
Less Common Side Effects (<1%): These are more serious and may require medical attention.
- Allergic reactions: Rash, itching, swelling, or difficulty breathing.
- Chest pain: A rare but serious side effect requiring immediate medical attention.
- Severe dizziness or fainting: This may indicate a significant drop in blood pressure.
If you experience any of these side effects, contact your healthcare provider immediately. Our telemedicine providers are available to assist with any concerns.
Contraindications
A contraindication is a specific condition where a medication should not be used due to potential harm. If you have any of the following conditions, avoid taking sodium ferric gluconate. Always consult your healthcare provider, and if needed, our telemedicine providers are available to discuss your treatment options.
- Allergy to iron products: If you have a known allergy to sodium ferric gluconate or other iron-containing products, taking this medication could cause a severe allergic reaction, including anaphylaxis, which can be life-threatening.
- Hemochromatosis or other iron overload disorders: Sodium ferric gluconate treats iron deficiency, so it should not be used if you have conditions like hemochromatosis, where your body stores too much iron. This could worsen your condition.
- Active infection: Iron can promote bacterial growth, so if you have an active infection, sodium ferric gluconate may not be appropriate. Your healthcare provider may recommend waiting until the infection resolves before starting treatment.
Drug Interactions with Sodium Ferric Gluconate
Certain medications may interact with sodium ferric gluconate, potentially increasing side effects or reducing its effectiveness. It’s important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements. Below are some medications that may interact with sodium ferric gluconate:
- ACE inhibitors (e.g., lisinopril, enalapril): These medications can raise the risk of allergic reactions when used alongside sodium ferric gluconate.
- Oral iron supplements (e.g., ferrous sulfate, ferrous gluconate): Taking these together with sodium ferric gluconate may lead to iron overload and increase the likelihood of side effects.
- Antibiotics (e.g., ciprofloxacin, doxycycline): Iron can interfere with the absorption of certain antibiotics, reducing their effectiveness. Your healthcare provider may recommend spacing out the doses to avoid this interaction.
Sodium Ferric Gluconate in Pregnancy
Is it safe to take sodium ferric gluconate during pregnancy?
Sodium ferric gluconate is generally considered safe during pregnancy when prescribed by your healthcare provider. Iron deficiency anemia is common during pregnancy, and untreated anemia can lead to complications for both the mother and baby. However, it’s crucial to discuss the potential benefits and risks with your provider. If you are pregnant and have been prescribed sodium ferric gluconate, don’t hesitate to raise any concerns with your healthcare provider or schedule a telemedicine visit to review your treatment plan.
Sodium Ferric Gluconate while Breastfeeding
Is it safe to take sodium ferric gluconate while breastfeeding?
There is limited information on the safety of sodium ferric gluconate during breastfeeding. However, since iron is a naturally occurring and essential nutrient for both mother and baby, it is generally considered safe when used as directed by your healthcare provider. If you are breastfeeding and have any concerns, consult your healthcare provider or schedule a telemedicine appointment to discuss your options.
Estimated Cost of Sodium Ferric Gluconate
The cost of a 30-day supply of sodium ferric gluconate without insurance can vary. With a GoodRX coupon, prices typically range from $50 to $150, depending on the pharmacy and location. Be sure to check with your local pharmacy or use a discount service like GoodRX to find the most affordable option.
Possible Alternatives to Sodium Ferric Gluconate
If sodium ferric gluconate is not the right option for you, other treatments and lifestyle changes may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan, or schedule a telemedicine visit to explore your alternatives.
- Iron deficiency anemia: Alternatives include oral iron supplements (e.g., ferrous sulfate), dietary changes to increase iron intake (e.g., red meat, leafy greens), and other intravenous iron formulations (e.g., iron sucrose).
- Chronic kidney disease: Erythropoiesis-stimulating agents (ESAs) like epoetin alfa (Procrit) or darbepoetin alfa (Aranesp) may be used alongside iron therapy to manage anemia.
- Anemia of chronic disease: Treatment focuses on managing the underlying condition, such as inflammation or infection. Iron supplementation may be recommended if iron deficiency is present.
- Hemodialysis-related anemia: Intravenous iron therapy, such as sodium ferric gluconate, is commonly used. ESAs may also be prescribed to stimulate red blood cell production.
- Pregnancy-related anemia: Oral iron supplements are often the first line of treatment. Dietary changes and prenatal vitamins containing iron may also be beneficial.
- Malnutrition-related anemia: Improving overall nutrition through a balanced diet or supplements can help. Iron-rich foods like beans, lentils, and fortified cereals may be recommended.
- Gastrointestinal bleeding: Treating the source of the bleeding is the priority. Iron supplementation may be necessary to restore iron levels after blood loss.
- Inflammatory bowel disease: Managing inflammation through medications like corticosteroids or biologics may improve anemia. Iron supplementation may be needed if iron deficiency is present.
- Cancer-related anemia: Treatment may include iron supplementation, ESAs, or blood transfusions, depending on the severity of the anemia and the type of cancer treatment.
- Post-surgical anemia: Iron supplementation or blood transfusions may be used to restore iron levels after significant blood loss during surgery.
Recent Updates on Sodium Ferric Gluconate Research
Recent studies have focused on optimizing the use of sodium ferric gluconate in specific populations, such as those with chronic kidney disease and cancer-related anemia. Research indicates that sodium ferric gluconate effectively improves hemoglobin levels and reduces the need for blood transfusions in these patients. Ongoing studies are also exploring the long-term safety and efficacy of sodium ferric gluconate when used in combination with other treatments, such as erythropoiesis-stimulating agents (ESAs). If you are interested in learning more about the latest research and how it may impact your treatment, consider scheduling a telemedicine visit with one of our providers today.
