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Sensipar (Cinacalcet): Uses, Dosage, and Side Effects Explained
Summary or Key Points
Sensipar (cinacalcet) is a medication used to manage conditions associated with elevated calcium levels, such as secondary hyperparathyroidism, parathyroid carcinoma, and chronic kidney disease. It works by reducing parathyroid hormone (PTH), calcium, and phosphorus levels in the body. Sensipar is typically prescribed for long-term use, but it’s essential to follow your healthcare provider’s instructions carefully. Always consult your doctor before making any changes to your dosage.
Names of Medication
US Brand Name: Sensipar
Generic Name: Cinacalcet
The generic name refers to the active ingredient in the medication. In this case, cinacalcet is the chemical compound responsible for the medication’s effects.
Pharmacologic Category
Calcimimetic Agents
Other medications in this category include etelcalcetide.
Sensipar Dosage
Sensipar is prescribed to treat several conditions. Below are the recommended doses for adults. Always consult your healthcare provider before adjusting your dose. If you have any questions, you can schedule a telemedicine appointment with one of our providers for personalized guidance.
Secondary Hyperparathyroidism (in patients with chronic kidney disease on dialysis)
Starting dose: 30 mg orally once daily
Maintenance dose: Adjust every 2 to 4 weeks based on PTH, calcium, and phosphorus levels
Maximum dose: 180 mg once daily
Primary Hyperparathyroidism (in patients who cannot undergo surgery)
Starting dose: 30 mg orally twice daily
Maintenance dose: Adjust every 2 to 4 weeks based on calcium levels
Maximum dose: 90 mg three times daily
Parathyroid Carcinoma
Starting dose: 30 mg orally twice daily
Maintenance dose: Adjust every 2 to 4 weeks based on calcium levels
Maximum dose: 90 mg four times daily
Hypercalcemia (in patients with parathyroid carcinoma or primary hyperparathyroidism)
Starting dose: 30 mg orally twice daily
Maintenance dose: Adjust every 2 to 4 weeks based on calcium levels
Maximum dose: 90 mg four times daily
If you have any of these conditions and are uncertain about your dosage, consult your healthcare provider. You can also schedule a telemedicine visit with one of our doctors for immediate assistance.
Dosage Forms and Strengths
Tablets: 30 mg, 60 mg, 90 mg
Administration Instructions for Sensipar
Sensipar should be taken orally with food or shortly after a meal to help minimize stomach discomfort. Swallow the tablet whole; do not crush, chew, or split it. It’s important to take Sensipar at the same time each day to maintain consistent levels in your body. If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Contraindications for Sensipar
A contraindication is a specific condition where a medication should not be used because it could be harmful. For Sensipar (cinacalcet), there are several contraindications to be aware of. If any of these apply to you, inform your healthcare provider before starting Sensipar. You can discuss your concerns with one of our providers through telemedicine.
Hypocalcemia (low calcium levels): Sensipar lowers calcium levels in the blood. If you already have low calcium, taking Sensipar could worsen it, leading to serious complications such as muscle spasms, seizures, or heart rhythm disturbances.
Allergic reaction to Sensipar: If you have had an allergic reaction to Sensipar or any of its ingredients, you should not take it again. Allergic reactions can cause symptoms like rash, itching, swelling, or difficulty breathing, which can be life-threatening.
Severe liver disease: Sensipar is processed by the liver. If your liver is not functioning properly, the medication could build up in your body, increasing the risk of toxicity or other side effects.
Drug Interactions with Sensipar
Certain medications can interact with Sensipar, increasing the risk of side effects or reducing the effectiveness of one or both drugs. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, supplements, and herbal products. Below are some common medications that may interact with Sensipar:
Ketoconazole (Nizoral): This antifungal medication can raise Sensipar levels in your blood, increasing the risk of side effects.
Itraconazole (Sporanox): Another antifungal, it can also elevate Sensipar levels in the bloodstream.
Ritonavir (Norvir): Used to treat HIV, ritonavir can increase Sensipar concentration in your blood, potentially leading to adverse effects.
Metoprolol (Lopressor, Toprol XL): Sensipar can enhance the effects of metoprolol, a beta-blocker used for high blood pressure and heart conditions, possibly causing a dangerously slow heart rate.
Desipramine (Norpramin): Sensipar may increase the levels of this antidepressant in the blood, raising the risk of side effects.
Sensipar in Pregnancy
Is it safe to take Sensipar during pregnancy?
The safety of Sensipar (cinacalcet) during pregnancy has not been well established. There is limited information available regarding its use in pregnant women, and animal studies suggest potential risks to the developing fetus. If you are pregnant or planning to become pregnant, it is essential to discuss the potential risks and benefits of taking Sensipar with your healthcare provider. Our telemedicine providers are also available to help you make an informed decision about your treatment options during pregnancy.
Sensipar While Breastfeeding
Is it safe to take Sensipar while breastfeeding?
It is not clear whether Sensipar passes into breast milk. Due to the possibility of serious side effects in a nursing infant, breastfeeding while taking Sensipar is generally not recommended unless your healthcare provider determines that the benefits outweigh the risks. Be sure to consult your healthcare provider to discuss the best course of action for both you and your baby.
Estimated Cost of Sensipar
The cost of Sensipar can vary depending on your location and the pharmacy you use. Without insurance, a 30-day supply of Sensipar (30 tablets of 30 mg) typically ranges between $500 and $600 when using a GoodRx coupon. Prices may fluctuate, so it is a good idea to check with your pharmacy or use a discount service like GoodRx to find the most affordable option.
Possible Alternatives to Sensipar
If Sensipar is not the right option for you, there are other treatments available for the conditions it addresses. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these alternatives.
Alternative Treatments for Secondary Hyperparathyroidism
Other treatment options include vitamin D analogs (such as calcitriol) or phosphate binders. Additionally, dietary changes, like reducing phosphorus intake, may help manage this condition.
Alternative Treatments for Primary Hyperparathyroidism
Surgery to remove the overactive parathyroid gland(s) is often the most effective treatment. In some cases, medications such as bisphosphonates or hormone replacement therapy may be considered.
Alternative Treatments for Chronic Kidney Disease
Managing chronic kidney disease often involves controlling blood pressure, blood sugar, and cholesterol levels. Lifestyle changes, including a low-sodium diet and regular exercise, are also important components of treatment.
Alternative Treatments for Hypercalcemia
Treatment options for hypercalcemia may include intravenous fluids, bisphosphonates, or calcitonin. In severe cases, dialysis may be necessary to manage the condition.
Alternative Treatments for Osteitis Fibrosa Cystica
This condition is typically treated by addressing the underlying hyperparathyroidism, either through medications like Sensipar or surgery.
Alternative Treatments for Bone Disease
Depending on the specific type of bone disease, treatments may include calcium and vitamin D supplements, bisphosphonates, or hormone therapy. Weight-bearing exercises can also help strengthen bones and improve overall bone health.
Alternative Treatments for Parathyroid Carcinoma
Surgery is the primary treatment for this rare form of cancer. In some cases, radiation therapy or chemotherapy may be used as part of the treatment plan.
Alternative Treatments for Renal Osteodystrophy
This condition is often managed by controlling phosphorus levels with phosphate binders and ensuring adequate intake of calcium and vitamin D.
Alternative Treatments for Hyperphosphatemia
Phosphate binders and dietary modifications to reduce phosphorus intake are commonly used to manage hyperphosphatemia.
Alternative Treatments for Hypoparathyroidism
Treatment for hypoparathyroidism typically involves calcium and vitamin D supplements to help maintain normal calcium levels in the blood.
Recent Updates on Sensipar Research
Recent studies have focused on the long-term effects of Sensipar in patients with chronic kidney disease and secondary hyperparathyroidism. One area of ongoing research is the potential cardiovascular benefits of Sensipar, as it may help reduce the risk of heart disease in patients with kidney disease. Additionally, researchers are exploring whether Sensipar can improve bone health outcomes in patients with renal osteodystrophy. While these studies are promising, more research is needed to fully understand the long-term benefits and risks of Sensipar. Be sure to talk to your healthcare provider about the latest research and how it may impact your treatment plan.
