Selegiline Transdermal Patch: Uses, Dosage & Side Effects

Summary of Key Points

Selegiline transdermal, often referred to as the Selegiline patch, is a prescription medication primarily used to treat major depressive disorder (MDD) and, less commonly, Parkinson’s disease. This transdermal antidepressant works by increasing specific brain chemicals, which can enhance mood and improve movement. Applied directly to the skin, the Selegiline patch provides a convenient alternative for individuals who prefer not to take oral medications. It is essential to consult your healthcare provider before starting or adjusting your dose to ensure safe and effective use.

Names of the Medication

US Brand Name: Emsam (Selegiline)

In the United States, the Selegiline transdermal patch is marketed under the brand name Emsam. The generic name, Selegiline, refers to the active ingredient in the medication. Generic names are standardized and universally recognized, regardless of the brand name.

Pharmacologic Category

Monoamine Oxidase Inhibitor (MAOI)

Selegiline Dosage and Uses

Selegiline transdermal is prescribed for various conditions, with the dosage and frequency tailored to the specific condition being treated. Always follow your doctor’s instructions and consult them before making any changes to your dose. For personalized advice, you can also schedule a telemedicine appointment with one of our providers.

Selegiline Dosage for Major Depressive Disorder (MDD)

The typical starting dose is one 6 mg/24-hour patch applied daily. Depending on your response and tolerance, your doctor may increase the dose to 9 mg/24 hours or 12 mg/24 hours. The duration of treatment varies based on individual progress and response to the medication.

Selegiline Uses for Parkinson’s Disease

While the Selegiline transdermal patch is not commonly used for Parkinson’s disease, oral forms of Selegiline are more frequently prescribed for this condition. Speak with your doctor to explore the most appropriate treatment options for Parkinson’s disease.

Off-Label Uses of Selegiline Transdermal

In some cases, Selegiline transdermal is prescribed off-label for conditions other than its primary indications. If you are considering off-label use, consult your healthcare provider for dosing recommendations and guidance. Potential off-label uses include:

1. Dysthymia: Off-label use
2. Alzheimer’s Disease: Off-label use
3. Attention Deficit Hyperactivity Disorder (ADHD): Off-label use
4. Anxiety Disorders: Off-label use
5. Schizophrenia: Off-label use
6. Chronic Pain: Off-label use
7. Restless Legs Syndrome (RLS): Off-label use
8. Narcolepsy: Off-label use

Dosage Forms and Strengths

The Selegiline transdermal patch is available in the following strengths:

1. 6 mg/24 hours
2. 9 mg/24 hours
3. 12 mg/24 hours

How to Use the Selegiline Patch

Selegiline transdermal is applied as a patch to the skin. Follow these steps to ensure proper application:

1. Apply the patch to a clean, dry, and hairless area of the upper torso, upper thigh, or upper arm.
2. Avoid placing the patch on irritated, broken, or damaged skin.
3. Replace the patch every 24 hours, rotating the application site to minimize the risk of skin irritation.
4. Wash your hands thoroughly after applying or removing the patch.

Always follow your healthcare provider’s instructions for use. If you have any questions or concerns, consult one of our telemedicine providers for additional support.

Selegiline Side Effects and Adverse Reactions

As with all medications, Selegiline transdermal may cause side effects. While many are mild and temporary, some can be more serious. If you experience severe side effects, contact your healthcare provider immediately.

Common Side Effects of Selegiline Transdermal

The following side effects are generally mild and may improve as your body adjusts to the medication:

1. Skin irritation at the application site
2. Headache
3. Nausea
4. Dizziness

Less Common Side Effects

These side effects may require medical attention if they persist or worsen:

1. Insomnia
2. Dry mouth
3. Weight loss

Serious Side Effects

Seek immediate medical attention if you experience any of the following symptoms:

1. High blood pressure
2. Hallucinations
3. Severe mood changes

Contraindications for Selegiline Transdermal

A contraindication refers to a specific condition or circumstance in which using a particular medication could pose a risk to your health. If you have any of the following conditions or are taking certain medications, the Selegiline transdermal patch may not be appropriate for you.

Allergy to Selegiline: If you have previously experienced an allergic reaction to Selegiline or any of its components, using this medication could lead to serious complications, such as a rash, swelling, or difficulty breathing. It’s important to inform your healthcare provider about any known allergies.

Use of other MAO inhibitors: Selegiline belongs to a class of medications called monoamine oxidase inhibitors (MAOIs). Combining it with other MAOIs, such as phenelzine, tranylcypromine, or isocarboxazid, can result in dangerously high blood pressure or other severe side effects. This combination should be strictly avoided.

Use of certain antidepressants: The Selegiline transdermal patch should not be used alongside other antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) like fluoxetine or sertraline, serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine or duloxetine, or tricyclic antidepressants such as amitriptyline or nortriptyline. Combining these medications can lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as agitation, rapid heart rate, and high fever.

Uncontrolled high blood pressure: Selegiline has the potential to elevate blood pressure, which can be dangerous for individuals with uncontrolled hypertension. In such cases, the medication could trigger a hypertensive crisis, a medical emergency requiring immediate attention.

Pheochromocytoma: This rare tumor of the adrenal glands can cause episodes of high blood pressure. Selegiline may worsen this condition, making it unsuitable for individuals with this diagnosis.

Use of certain pain medications: Opioid pain relievers such as meperidine, tramadol, or methadone can interact with Selegiline, potentially leading to severe side effects like serotonin syndrome or respiratory depression. These combinations should be avoided unless specifically directed by a healthcare provider.

Drug-to-Drug Interactions with Selegiline Transdermal

The Selegiline transdermal patch can interact with a variety of medications, which may increase the risk of side effects or reduce the effectiveness of treatment. Below are some common medications that may interact with Selegiline:

1. Antidepressants: Fluoxetine (Prozac), Sertraline (Zoloft), Venlafaxine (Effexor), Duloxetine (Cymbalta), Amitriptyline (Elavil), Nortriptyline (Pamelor)
2. Opioid pain medications: Meperidine (Demerol), Tramadol (Ultram), Methadone (Methadose)
3. Other MAO inhibitors: Phenelzine (Nardil), Tranylcypromine (Parnate), Isocarboxazid (Marplan)
4. Stimulants: Amphetamines (Adderall), Methylphenidate (Ritalin)
5. Decongestants: Pseudoephedrine (Sudafed)
6. Herbal supplements: St. John’s Wort, Ginseng

It is essential to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs, vitamins, and herbal supplements, before starting the Selegiline transdermal patch. If you are uncertain about potential interactions, consult with your healthcare provider or one of our telemedicine specialists for a comprehensive review of your medications.

Selegiline Transdermal Patch and Pregnancy

Is it safe to use the Selegiline transdermal patch during pregnancy?

There is limited information available regarding the safety of the Selegiline transdermal patch during pregnancy. While animal studies suggest there may be some risk to the developing fetus, there is insufficient research in humans to draw definitive conclusions. As a precaution, the Selegiline transdermal patch is generally not recommended during pregnancy unless the potential benefits clearly outweigh the risks. If you are pregnant or planning to become pregnant, discuss your treatment options with your healthcare provider. Our telemedicine providers are available to help you explore safer alternatives if necessary.

Selegiline Transdermal Patch While Breastfeeding

Is it safe to use the Selegiline transdermal patch while breastfeeding?

Currently, there is not enough data to determine whether Selegiline passes into breast milk or if it could harm a nursing infant. Due to this lack of information, it is generally advised to avoid using the Selegiline transdermal patch while breastfeeding. If you are breastfeeding or planning to breastfeed, consult your healthcare provider to discuss safer treatment options that prioritize both your health and your baby’s well-being.

Estimated Cost of the Selegiline Transdermal Patch

The cost of a 30-day supply of the Selegiline transdermal patch (6 mg/24 hours) without insurance typically ranges from $450 to $500. However, using a GoodRx coupon can lower the price to approximately $300 to $350. Prices may vary depending on the pharmacy and location. Be sure to explore available discounts or coupons to help reduce your out-of-pocket expenses.

Possible Alternatives to Selegiline Transdermal

If the **Selegiline transdermal patch** is not the right fit for you, there are other treatment options and lifestyle adjustments that may help manage the conditions it is prescribed for. It’s important to consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are here to support you in exploring these alternatives.

Parkinson’s Disease

For Parkinson’s disease, alternatives to **Selegiline** include other MAO-B inhibitors such as rasagiline (Azilect), dopamine agonists like pramipexole (Mirapex), or the combination therapy of levodopa and carbidopa (Sinemet). Engaging in physical therapy and maintaining a regular exercise routine can also help reduce symptoms and improve overall quality of life.

Major Depressive Disorder

When treating major depressive disorder, other antidepressants such as SSRIs (e.g., sertraline, fluoxetine) or SNRIs (e.g., venlafaxine, duloxetine) may be effective alternatives. Additionally, cognitive-behavioral therapy (CBT) and lifestyle modifications, including consistent exercise and mindfulness practices, can provide meaningful relief and enhance emotional well-being.

Dysthymia

Similar to major depressive disorder, dysthymia can be managed with SSRIs, SNRIs, and psychotherapy. These approaches aim to alleviate symptoms and promote long-term mental health stability.

Alzheimer’s Disease

For Alzheimer’s disease, commonly prescribed medications include cholinesterase inhibitors like donepezil (Aricept) and NMDA receptor antagonists such as memantine (Namenda). Complementary strategies, such as cognitive exercises, a nutrient-rich diet, and regular physical activity, may also support brain health and potentially slow disease progression.

Attention Deficit Hyperactivity Disorder (ADHD)

ADHD is often managed with stimulant medications like methylphenidate (Ritalin) or amphetamines (Adderall). Behavioral therapy and lifestyle adjustments, such as creating structured routines and minimizing distractions, can further enhance focus and reduce hyperactivity.

Anxiety Disorders

Treatment options for anxiety disorders typically include SSRIs, SNRIs, and, in some cases, benzodiazepines for short-term relief. Non-pharmacological approaches, such as cognitive-behavioral therapy and relaxation techniques like yoga or meditation, can also help manage symptoms and improve overall well-being.

Schizophrenia

For schizophrenia, antipsychotic medications such as risperidone (Risperdal) or aripiprazole (Abilify) are commonly prescribed. Psychotherapy, combined with a strong support network, plays a vital role in achieving effective, long-term management of the condition.

Chronic Pain

Chronic pain is often treated with non-opioid pain relievers like acetaminophen or NSAIDs, alongside physical therapy. Incorporating regular exercise and stress management techniques into your daily routine can also help reduce pain and improve overall quality of life.

Restless Legs Syndrome

For restless legs syndrome, dopamine agonists such as pramipexole (Mirapex) or medications like gabapentin (Neurontin) are frequently used. Establishing good sleep hygiene and engaging in regular physical activity can further alleviate symptoms and enhance sleep quality.

Narcolepsy

Common treatments for narcolepsy include stimulants like modafinil (Provigil) or sodium oxybate (Xyrem). Maintaining consistent sleep hygiene practices and scheduling regular naps can also help manage symptoms effectively and improve daily functioning.

Recent Updates on Selegiline Transdermal Research

Recent studies have highlighted the potential neuroprotective effects of the **Selegiline transdermal patch**, particularly in neurodegenerative conditions such as Parkinson’s and Alzheimer’s disease. Research suggests that **Selegiline** may help slow disease progression by reducing oxidative stress and inflammation in the brain. However, additional clinical trials are needed to confirm these findings and evaluate the long-term benefits of **Selegiline** in these conditions.

Furthermore, ongoing research is examining the use of the **Selegiline transdermal patch** for treatment-resistant depression. Preliminary results indicate that this **transdermal antidepressant** may offer relief for individuals who have not responded to other medications. Nevertheless, further studies are required to establish its safety and efficacy in this population.

As new research continues to emerge, staying informed about the latest developments is crucial. Our telemedicine providers are available to discuss any updates or new treatment options with you, ensuring you have access to the most current information about the **Selegiline transdermal patch** and its potential benefits.

James Kingsley

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