Pylera Treatment: Dosage, Side Effects, and H. Pylori Cure Guide

Summary of Key Points

Pylera is a prescription medication used to treat infections caused by Helicobacter pylori (H. pylori), a type of bacteria linked to stomach ulcers and other gastrointestinal conditions. It combines three active ingredients: bismuth subcitrate potassium, metronidazole, and tetracycline. Pylera works by eliminating the bacteria and reducing stomach acid. It is important to take Pylera exactly as prescribed by your healthcare provider and consult them before making any changes to your treatment plan.

Names of Medication

US Brand Name: Pylera

Generic Name: bismuth subcitrate potassium, metronidazole, and tetracycline

The generic name refers to the active ingredients in a medication, which remain consistent across different brands. In this case, the generic name is listed in parentheses.

Pharmacologic Category

Pylera belongs to the following pharmacologic categories:

1. Antibiotic combination
2. Antibacterial
3. Antiulcer agent

Pylera Dosage Instructions

Pylera is prescribed to treat various gastrointestinal conditions in adults, particularly those related to Helicobacter pylori infection. Below are the specific dosing instructions for each condition. Always consult your healthcare provider before adjusting your dose. You can also schedule a telemedicine appointment with one of our providers for personalized advice.

Helicobacter pylori Infection

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Peptic Ulcer Disease

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Gastritis

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Duodenal Ulcer

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Gastric Ulcer

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Stomach Cancer (H. pylori-related)

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Dyspepsia

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Gastroesophageal Reflux Disease (GERD)

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Nonsteroidal Anti-inflammatory Drug (NSAID)-Induced Ulcers

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Zollinger-Ellison Syndrome

Dose: 3 capsules taken 4 times daily (after meals and at bedtime)

Duration: 10 days

Dosage Forms and Strengths

Capsules: Each Pylera capsule contains 140 mg of bismuth subcitrate potassium, 125 mg of metronidazole, and 125 mg of tetracycline.

Contraindications for Pylera Treatment

A contraindication is a specific condition or situation where a medication should not be used because it may cause harm. If you have any of the following conditions, Pylera may not be safe for you. Always consult your healthcare provider before starting any new medication, including Pylera.

1. Severe kidney disease: Pylera contains bismuth subcitrate, which can build up in the body if your kidneys are not functioning properly, leading to toxicity and other serious side effects.
2. Severe liver disease: The liver plays a crucial role in processing medications. If you have severe liver disease, your body may not clear the components of Pylera effectively, increasing the risk of side effects.
3. Allergy to any of the ingredients: If you are allergic to bismuth subcitrate, metronidazole, tetracycline, or any other ingredients in Pylera, taking this medication can cause a severe allergic reaction, which may be life-threatening.
4. Pregnancy: Pylera contains tetracycline, which can harm an unborn baby, particularly affecting bone and tooth development. It is not recommended during pregnancy (see more details below).
5. Children under 8 years old: Tetracycline can affect bone growth and cause permanent tooth discoloration in children. Therefore, Pylera is not recommended for young children.

Drug-to-Drug Interactions with Pylera

Pylera can interact with other medications, potentially affecting how well Pylera or the other medications work, or increasing the risk of side effects. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Some known interactions include:

1. Warfarin (Coumadin): Pylera can increase the effects of warfarin, a blood thinner, raising the risk of bleeding.
2. Disulfiram (Antabuse): Metronidazole, a component of Pylera, can cause a severe reaction when taken with disulfiram, leading to confusion and psychosis.
3. Oral contraceptives (birth control pills): Tetracycline may reduce the effectiveness of birth control pills. You may need to use an additional form of contraception while taking Pylera.
4. Antacids containing aluminum, calcium, or magnesium: These can interfere with tetracycline absorption, reducing Pylera’s effectiveness.
5. Iron supplements: Iron can also reduce tetracycline absorption, making Pylera less effective.

Pylera in Pregnancy

Is it safe to take Pylera when pregnant?

No, Pylera is not considered safe during pregnancy. One of its active ingredients, tetracycline, can harm the developing baby by affecting bone and tooth development. Tetracycline may cause permanent tooth discoloration and impair bone growth. If you are pregnant or planning to become pregnant, it is essential to consult your healthcare provider about alternative treatments. If you are currently taking Pylera and discover you are pregnant, contact your healthcare provider immediately to discuss the best course of action.

Pylera While Breastfeeding

Is it safe to take Pylera while breastfeeding?

Pylera is not recommended for use while breastfeeding. Tetracycline, one of the ingredients in Pylera, can pass into breast milk and may affect the bone and tooth development of a nursing infant. Additionally, metronidazole, another component of Pylera, can also be transferred through breast milk and may cause side effects in the baby. If you are breastfeeding, it is important to consult your healthcare provider to explore safer treatment alternatives.

Estimated Cost of Pylera Medication

The estimated cost of a 30-day supply of Pylera without insurance, using a GoodRX coupon, typically ranges from $800 to $1,000. Prices may vary depending on the pharmacy and your location. It’s a good idea to check with your pharmacy for the most accurate pricing and explore coupon options to help reduce costs.

Possible Alternatives to Pylera Treatment

If you are unable to take Pylera or are looking for alternative treatments, there are other options available depending on your specific condition. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore these options further.

Helicobacter Pylori Infection

Alternative treatments for Helicobacter pylori infection often involve a combination of proton pump inhibitors (PPIs), such as omeprazole (Prilosec), along with antibiotics like amoxicillin or clarithromycin. In some cases, a quadruple therapy regimen may be recommended.

Peptic Ulcer Disease

Lifestyle changes, such as avoiding NSAIDs, reducing alcohol consumption, and managing stress, can be beneficial. Medications like PPIs (e.g., esomeprazole) or H2 blockers (e.g., ranitidine) may also be prescribed to promote healing.

Gastritis

Avoiding irritants such as alcohol, spicy foods, and NSAIDs can help alleviate symptoms. PPIs or H2 blockers may be used to reduce stomach acid and support healing.

Duodenal Ulcer

PPIs or H2 blockers are commonly prescribed to reduce acid production and allow the ulcer to heal. Lifestyle modifications, such as quitting smoking and limiting alcohol intake, can also aid in recovery.

Gastric Ulcer

Similar to duodenal ulcers, treatment typically includes PPIs or H2 blockers. Avoiding NSAIDs and other irritants is also recommended to prevent further damage.

Stomach Cancer

Treatment options for stomach cancer may include surgery, chemotherapy, radiation therapy, or targeted therapy, depending on the stage and type of cancer. Early detection is crucial, so regular screenings are important for those at risk.

Dyspepsia

Lifestyle adjustments, such as eating smaller meals, avoiding trigger foods, and managing stress, can help relieve symptoms. Medications like antacids, PPIs, or H2 blockers may also be prescribed to manage discomfort.

Gastroesophageal Reflux Disease (GERD)

Lifestyle changes, such as elevating the head of your bed, avoiding large meals, and maintaining a healthy weight, can help reduce symptoms. PPIs or H2 blockers are often used to manage acid reflux and prevent further complications.

Nonsteroidal Anti-Inflammatory Drug (NSAID)-Induced Ulcers

Discontinuing NSAIDs and switching to alternative pain relievers, such as acetaminophen, can help prevent further damage. PPIs or H2 blockers may be prescribed to heal the ulcer and protect the stomach lining.

Zollinger-Ellison Syndrome

High doses of PPIs are often necessary to control excessive stomach acid production. In some cases, surgery or medications to reduce gastrin levels may also be considered as part of the treatment plan.

Recent Updates on Pylera Research

Recent research on Pylera has focused on its effectiveness in eradicating Helicobacter pylori infections, particularly in patients who have not responded to other treatments. Studies indicate that Pylera, when combined with a proton pump inhibitor, can be highly effective in treating H. pylori, even in cases of antibiotic resistance. Ongoing research is also exploring shorter treatment durations and new formulations to improve patient adherence. Stay informed about new developments and discuss them with your healthcare provider.

James Kingsley

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