Polyethylene Glycol 3350: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Polyethylene glycol 3350, commonly referred to as PEG 3350, is a widely used laxative for treating constipation and other bowel-related conditions. It works by drawing water into the intestines, which softens the stool and makes it easier to pass. Available both over-the-counter and by prescription, it’s important to consult a healthcare provider before starting or adjusting your dose. Our telemedicine providers are available to assist with any questions or concerns you may have.

Names of Medication

MiraLAX (Polyethylene glycol 3350)

The generic name, Polyethylene glycol 3350, is the active ingredient in the medication, listed in parentheses. Generic names are often used to refer to the medication, regardless of the brand name.

Pharmacologic Category

Osmotic Laxatives

Polyethylene Glycol 3350 Dosage

Polyethylene glycol 3350 is used to treat various bowel-related conditions. Below are the recommended doses for adults. Always consult your doctor before adjusting your dose. Our telemedicine providers can help determine the right dosage for your specific condition.

Constipation

17 grams (approximately 1 heaping tablespoon) dissolved in 4-8 ounces of water, taken once daily. The duration of treatment may vary, but it should not exceed 2 weeks without consulting a healthcare provider.

Fecal Impaction

17 grams dissolved in 4-8 ounces of water, taken once daily. The length of treatment depends on the severity of the impaction. Consult your doctor for personalized guidance.

Irritable Bowel Syndrome (IBS) with Constipation

17 grams dissolved in 4-8 ounces of water, taken once daily. Discuss the appropriate treatment duration with your healthcare provider.

Bowel Preparation for Colonoscopy

Follow your doctor’s specific instructions for bowel preparation. Typically, a higher dose is used, taken in multiple stages. Consult your healthcare provider for exact dosing instructions.

Chronic Idiopathic Constipation

17 grams dissolved in 4-8 ounces of water, taken once daily. Treatment may be long-term, but always consult your doctor before continuing use over an extended period.

Opioid-Induced Constipation

17 grams dissolved in 4-8 ounces of water, taken once daily. The duration of treatment depends on the length of opioid use. Consult your healthcare provider for further instructions.

Diverticular Disease

17 grams dissolved in 4-8 ounces of water, taken once daily. Discuss the appropriate treatment duration with your healthcare provider.

Functional Constipation

17 grams dissolved in 4-8 ounces of water, taken once daily. The length of treatment varies based on symptoms. Consult your doctor for guidance.

Post-Operative Constipation

17 grams dissolved in 4-8 ounces of water, taken once daily. The duration of treatment depends on your recovery and should be discussed with your healthcare provider.

Encopresis (Involuntary Fecal Soiling)

17 grams dissolved in 4-8 ounces of water, taken once daily. The treatment duration should be individualized based on patient needs. Consult your doctor for further instructions.

Dosage Forms and Strengths

Powder for oral solution: 17 grams per dose (available in bottles or single-dose packets)

Administration Instructions for Polyethylene Glycol 3350

Polyethylene glycol 3350 should be dissolved in 4-8 ounces of water, juice, soda, coffee, or tea before drinking. Stir well until the powder is fully dissolved. It can be taken with or without food. Do not exceed the recommended dose unless directed by your healthcare provider. If you miss a dose, take it as soon as you remember, but do not double up on doses. Always consult a healthcare provider if you have concerns about how to take this medication.

Contraindications for Polyethylene Glycol 3350

A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. If you have any of the conditions listed below, you should not take Polyethylene glycol 3350. Always consult with a healthcare provider, such as one of our telemedicine providers, before starting any new medication.

Known Allergic Reaction to Polyethylene Glycol: If you have had an allergic reaction to polyethylene glycol or any of its components, taking this medication could cause serious allergic reactions, including rash, itching, swelling, or difficulty breathing.

Bowel Obstruction: Polyethylene glycol 3350 is contraindicated in patients with a known or suspected bowel obstruction. The medication works by drawing water into the intestines, which could worsen the blockage and lead to serious complications.

Intestinal Perforation: If there is a tear or hole in the intestinal wall, taking Polyethylene glycol 3350 can lead to leakage of intestinal contents into the abdomen, causing severe infection or other complications.

Severe Inflammatory Bowel Disease (IBD): In conditions like Crohn’s disease or ulcerative colitis, the use of Polyethylene glycol 3350 may exacerbate symptoms or lead to further inflammation of the intestines.

Drug-to-Drug Interactions

Polyethylene glycol 3350 generally has a low risk of interacting with other medications, but some drugs may interact with it. Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.

Diuretics (e.g., Lasix, furosemide): These medications can increase the risk of dehydration when used with Polyethylene glycol 3350, as both can lead to increased water loss from the body.

Electrolyte Supplements (e.g., Pedialyte, potassium supplements): Polyethylene glycol 3350 may affect your body’s electrolyte balance, so taking electrolyte supplements may require monitoring to avoid imbalances.

Antibiotics (e.g., Cipro, ciprofloxacin): Some antibiotics may be less effective if taken too close to Polyethylene glycol 3350, as it can speed up the passage of food and medications through the intestines, reducing absorption.

Polyethylene Glycol 3350 in Pregnancy

Is it safe to take Polyethylene Glycol 3350 when pregnant?

Polyethylene Glycol 3350 is generally considered safe for use during pregnancy. It is classified as a Category C drug by the FDA, meaning that while there are no well-controlled studies in pregnant women, animal studies have not demonstrated harm to the fetus. However, it is always essential to consult your healthcare provider before taking any medication during pregnancy. If you’re experiencing constipation, our telemedicine providers can assist you in finding the most appropriate treatment plan.

Polyethylene Glycol 3350 While Breastfeeding

Is it safe to take Polyethylene Glycol 3350 while breastfeeding?

Polyethylene Glycol 3350 is considered safe to use while breastfeeding. The medication is minimally absorbed into the bloodstream, meaning that very little, if any, passes into breast milk. Nevertheless, it’s always a good idea to consult your healthcare provider before using any medication while breastfeeding to ensure it’s the best option for both you and your baby.

Estimated Cost of Polyethylene Glycol 3350

The cost of a 30-day supply of Polyethylene Glycol 3350 can vary depending on the pharmacy and location. With a GoodRX coupon, the estimated cost without insurance typically ranges from $10 to $20. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a discount service like GoodRX for the most up-to-date pricing.

Possible Alternatives to Polyethylene Glycol 3350

If Polyethylene Glycol 3350 isn’t the right option for you, or if you’re looking for alternatives, several other treatments are available. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are also available to help you explore these options.

Constipation

Alternatives include increasing dietary fiber, drinking more water, and using other over-the-counter laxatives such as docusate sodium (Colace) or senna (Senokot). Regular physical activity can also help promote healthy bowel movements.

Fecal Impaction

In some cases, manual removal of impacted stool by a healthcare provider may be necessary. Other treatments include enemas or suppositories, such as glycerin suppositories, to soften the stool and facilitate passage.

Irritable Bowel Syndrome (IBS)

For IBS, dietary changes, such as following a low FODMAP diet, and medications like lubiprostone (Amitiza) or linaclotide (Linzess) may be helpful. Additionally, stress management techniques, including mindfulness or cognitive-behavioral therapy, can improve symptoms.

Bowel Preparation for Colonoscopy

Other bowel preparation solutions include sodium phosphate (OsmoPrep) or sodium sulfate (Suprep). Always follow your healthcare provider’s instructions carefully when preparing for a colonoscopy.

Chronic Idiopathic Constipation

Prescription medications such as prucalopride (Motegrity) or linaclotide (Linzess) may be alternatives. Lifestyle changes, including regular exercise and a high-fiber diet, can also support bowel regularity.

Opioid-Induced Constipation

For constipation caused by opioid use, medications like naloxegol (Movantik) or methylnaltrexone (Relistor) are specifically designed to address this issue.

Diverticular Disease

Managing diverticular disease often involves increasing dietary fiber and staying well-hydrated. In some cases, antibiotics or surgery may be required if complications such as infection or abscesses occur.

Functional Constipation

Behavioral therapies, such as biofeedback, along with medications like lubiprostone (Amitiza) or linaclotide (Linzess), may be effective. Increasing fiber intake and staying hydrated are also recommended.

Post-Operative Constipation

After surgery, stool softeners like docusate sodium (Colace) or stimulant laxatives like bisacodyl (Dulcolax) may help relieve constipation. Gentle physical activity, such as walking, can also encourage bowel movements.

Encopresis

Treatment for encopresis often involves a combination of stool softeners, behavioral therapy, and establishing regular bowel habits. In some cases, a healthcare provider may recommend a bowel cleanout regimen to address the issue.

Recent Updates on Polyethylene Glycol 3350 Research

Recent research on Polyethylene Glycol 3350 has focused on its long-term safety and effectiveness, particularly in pediatric and elderly populations. Studies have shown that Polyethylene Glycol 3350 is effective in treating chronic constipation in both children and adults, with minimal side effects. Ongoing research is also exploring its use in combination with other medications for more complex cases, such as opioid-induced constipation.

Additionally, newer studies are investigating Polyethylene Glycol 3350’s role in managing constipation related to neurological conditions, such as Parkinson’s disease. These studies aim to provide more tailored treatment options for patients with specific medical needs.

As always, staying informed about the latest research is important. Be sure to discuss any new treatment options with your healthcare provider. Our telemedicine providers are available to help you navigate these updates and determine the best course of action for your health.

James Kingsley

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