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Plecanatide: Chronic Idiopathic Constipation Treatment & Dosage Guide
Summary of Key Points
Plecanatide is a prescription medication used to treat certain types of constipation, including chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). It works by promoting smoother bowel movements, making it easier to pass stools. Typically taken once daily, Plecanatide is available in tablet form. Always consult your healthcare provider before starting or adjusting your dose.
Names of Medication
US Brand Name: Trulance
Generic Name: Plecanatide
The generic name refers to the active ingredient in the medication and is listed in parentheses next to the brand name.
Pharmacologic Category
Plecanatide belongs to the pharmacologic category of Guanylate Cyclase-C (GC-C) Agonists, which are used in gastrointestinal treatments to help regulate bowel movements.
Plecanatide Dosage
Plecanatide is prescribed for adults to manage constipation-related conditions. Below are the recommended doses for each condition:
Chronic Idiopathic Constipation (CIC) Treatment
Adults: 3 mg taken orally once daily. The duration of treatment depends on the patient’s response and the healthcare provider’s recommendation.
Plecanatide for Irritable Bowel Syndrome with Constipation (IBS-C)
Adults: 3 mg taken orally once daily. The length of treatment may vary based on the severity of symptoms and your healthcare provider’s guidance.
Always consult your healthcare provider before making any changes to your dose. If needed, you can schedule a telemedicine appointment with one of our specialists today.
Dosage Forms and Strengths
Tablet: 3 mg
Administration Instructions for Plecanatide
Plecanatide should be taken orally, with or without food. Swallow the tablet whole; do not crush, chew, or break it. If you have difficulty swallowing, the tablet can be crushed and mixed with applesauce or dissolved in water. Follow your healthcare provider’s instructions carefully. If you miss a dose, take it as soon as you remember, but avoid taking two doses at once.
Plecanatide Side Effects and Adverse Reactions
Like all medications, Plecanatide may cause side effects. Below are some potential side effects, categorized by frequency:
Common (affects more than 1 in 10 people): Diarrhea – This is the most frequently reported side effect. If diarrhea becomes severe, stop taking the medication and consult your doctor.
Less Common (affects 1 in 100 to 1 in 10 people): Abdominal pain, bloating, gas – These symptoms may occur but are generally mild.
Rare (affects fewer than 1 in 100 people): Allergic reactions – Symptoms may include rash, itching, or swelling. Seek medical attention immediately if you experience any of these symptoms.
If you experience any side effects, contact your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to discuss your symptoms.
Contraindications for Plecanatide
A contraindication is a specific situation where a medication should not be used because it may cause harm. It’s important to know if you have any conditions that make taking Plecanatide unsafe. Below are the contraindications for Plecanatide:
Children under 6 years of age: Plecanatide is contraindicated in children under 6 due to the risk of severe dehydration, which can be life-threatening. The safety and effectiveness of Plecanatide in children have not been established.
Known or suspected mechanical gastrointestinal obstruction: If you have a blockage in your intestines (bowel obstruction), Plecanatide could worsen the condition by increasing fluid secretion in the intestines, leading to more pressure and discomfort.
Hypersensitivity to Plecanatide or any of its ingredients: If you have had an allergic reaction to Plecanatide or any of its components, you should not take this medication, as it could lead to severe allergic reactions, including anaphylaxis.
Drug-to-Drug Interactions with Plecanatide
Drug interactions can affect how medications work or increase the risk of serious side effects. It’s important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Below are some medications that may interact with Plecanatide:
- Anticholinergics (e.g., Benadryl [diphenhydramine]): These medications can slow down bowel movements, which may counteract the effects of Plecanatide.
- Opioids (e.g., OxyContin [oxycodone]): Opioids can cause constipation, which may reduce the effectiveness of Plecanatide in treating constipation.
- Diuretics (e.g., Lasix [furosemide]): Diuretics increase urine output and may lead to dehydration, which can worsen Plecanatide’s side effects, such as diarrhea.
Plecanatide in Pregnancy
Is it safe to take Plecanatide during pregnancy?
There is limited information available regarding the use of Plecanatide during pregnancy. While animal studies have not shown harm to the fetus, there are no well-controlled studies in humans. As a result, Plecanatide should only be used during pregnancy if the potential benefits outweigh the risks. If you are pregnant or planning to become pregnant, it is important to consult your healthcare provider before starting Plecanatide. You can also speak with one of our providers through telemedicine to discuss your options in more detail.
Plecanatide while Breastfeeding
Is it safe to take Plecanatide while breastfeeding?
It is not known whether Plecanatide passes into breast milk. Since the medication primarily acts within the gastrointestinal tract and is minimally absorbed into the bloodstream, the risk to a breastfeeding infant is likely low. However, due to the lack of specific studies, it is essential to consult your healthcare provider before taking Plecanatide while breastfeeding. You can also schedule a telemedicine appointment with one of our providers to address any concerns you may have.
Estimated Cost of Plecanatide Medication
The cost of a 30-day supply of Plecanatide (brand name Trulance) without insurance can vary. With a GoodRx coupon, the estimated cost ranges from $450 to $500 for a 30-day supply. Prices may differ depending on the pharmacy and your location.
Possible Alternatives to Plecanatide
If Plecanatide is not the right option for you, there are alternative treatments and lifestyle modifications that may help manage your condition. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these options.
Chronic Idiopathic Constipation Treatment Alternatives
Alternative treatments include fiber supplements, stool softeners (e.g., Colace [docusate]), or other prescription medications such as linaclotide (brand name Linzess). Increasing dietary fiber and water intake may also provide relief.
Treatment Options for Irritable Bowel Syndrome with Constipation (IBS-C)
Other treatment options include lubiprostone (brand name Amitiza) or dietary adjustments, such as following a low-FODMAP diet. Probiotics may also be beneficial for some individuals.
Opioid-Induced Constipation Solutions
Medications like methylnaltrexone (brand name Relistor) or naloxegol (brand name Movantik) may be considered. Reducing opioid use, if possible, can also help alleviate constipation.
Functional Constipation Management
Lifestyle changes, such as increasing physical activity, staying hydrated, and consuming a high-fiber diet, can be effective. Over-the-counter laxatives like polyethylene glycol (brand name Miralax) may also provide relief.
General Constipation Remedies
Simple remedies include increasing fiber intake, drinking plenty of water, and using over-the-counter laxatives when necessary. Be sure to discuss these options with your healthcare provider to determine what is best for you.
Gastrointestinal Disorders and Treatment Options
Depending on the specific gastrointestinal disorder, treatment options may include dietary changes, probiotics, or medications such as antispasmodics (e.g., Bentyl [dicyclomine]). Consult your healthcare provider for a personalized treatment plan tailored to your needs.
Bowel Obstruction Warning
A bowel obstruction is a medical emergency that requires immediate treatment. Do not take Plecanatide if you have a bowel obstruction. Surgery or other interventions may be necessary to resolve the condition.
Colonic Inertia Treatment Options
Treatment options for colonic inertia may include surgical procedures, biofeedback therapy, or medications such as prucalopride (brand name Motegrity).
Fecal Impaction Management
Fecal impaction may require manual removal of stool or the use of enemas. Plecanatide is not recommended for this condition.
Dysmotility Disorders and Treatment
Treatment for dysmotility disorders may involve medications to improve gut motility, dietary changes, or, in severe cases, surgical interventions. Consult your healthcare provider to determine the best course of action for your specific condition.
Recent Updates on Plecanatide Research
Recent studies have focused on the long-term safety and effectiveness of Plecanatide in treating chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C). A 2021 study published in the journal Gastroenterology found that Plecanatide was well-tolerated and effective in improving bowel movements and reducing abdominal pain in patients with IBS-C over a 12-week period. Additionally, ongoing research is exploring the potential use of Plecanatide in other gastrointestinal disorders, such as opioid-induced constipation. These findings suggest that Plecanatide may continue to be a valuable treatment option for patients with various forms of constipation.
As new research emerges, staying informed is crucial. You can always reach out to one of our telemedicine providers to discuss the latest treatment options and how they may apply to your condition.
