Front Desk: 469-391-0070
Perindopril: ACE Inhibitor Uses, Dosage, and Side Effects Guide
Summary of Key Points
Perindopril is a prescription medication used to manage high blood pressure, heart failure, and other cardiovascular conditions. It belongs to a class of drugs known as ACE inhibitors, which work by relaxing blood vessels and improving blood flow. This medication can help reduce the risk of heart attacks and strokes. Always consult your healthcare provider before starting or adjusting your dose, and consider scheduling a telemedicine appointment with one of our providers for personalized advice.
Names of Medication
US Brand Name: Aceon
Generic Name: Perindopril
The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. The generic name is often listed in parentheses.
Pharmacologic Category
Angiotensin-Converting Enzyme (ACE) Inhibitor
Perindopril Dosage
Perindopril is prescribed for various conditions, and the dosage may differ depending on the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. You can also schedule a telemedicine appointment with one of our providers for further guidance.
Perindopril for Hypertension (High Blood Pressure)
Initial dose: 4 mg once daily
Maintenance dose: 4-8 mg once daily
Duration: Long-term treatment
Perindopril for Heart Failure
Initial dose: 2 mg once daily
Maintenance dose: 4 mg once daily
Duration: Long-term treatment
Perindopril for Coronary Artery Disease
Initial dose: 4 mg once daily
Maintenance dose: 8 mg once daily
Duration: Long-term treatment
Perindopril for Left Ventricular Dysfunction
Initial dose: 2 mg once daily
Maintenance dose: 4 mg once daily
Duration: Long-term treatment
Perindopril for Diabetic Nephropathy
Initial dose: 2 mg once daily
Maintenance dose: 4 mg once daily
Duration: Long-term treatment
Perindopril for Chronic Kidney Disease
Initial dose: 2 mg once daily
Maintenance dose: 4 mg once daily
Duration: Long-term treatment
Perindopril for Stroke Prevention
Initial dose: 4 mg once daily
Maintenance dose: 8 mg once daily
Duration: Long-term treatment
Perindopril for Myocardial Infarction (Heart Attack)
Initial dose: 2 mg once daily
Maintenance dose: 4 mg once daily
Duration: Long-term treatment
Perindopril for Atrial Fibrillation
Initial dose: 2 mg once daily
Maintenance dose: 4 mg once daily
Duration: Long-term treatment
Perindopril for Peripheral Artery Disease
Initial dose: 2 mg once daily
Maintenance dose: 4 mg once daily
Duration: Long-term treatment
Dosage Forms and Strengths
Tablet: 2 mg, 4 mg, 8 mg
Administration Instructions for Perindopril
Perindopril is typically taken once daily, with or without food. It’s important to take it at the same time each day. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Never double up on doses. Always follow your healthcare provider’s instructions carefully.
Contraindications
A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. Before starting any new medication, it’s important to understand whether you have any conditions or are taking any other medications that could make the drug unsafe for you.
Contraindications for Perindopril
Allergy to ACE inhibitors: If you have had an allergic reaction to Perindopril or any other ACE inhibitors (such as Lisinopril or Enalapril), you should not take this medication. Allergic reactions can cause severe swelling (angioedema), difficulty breathing, and other life-threatening symptoms.
History of angioedema: Perindopril can increase the risk of angioedema, a condition that causes swelling under the skin, particularly in the face, throat, and extremities. If you have a history of this condition, Perindopril is not recommended.
Pregnancy: Perindopril can cause harm to an unborn baby, especially during the second and third trimesters. It is contraindicated in pregnancy due to the risk of birth defects, low blood pressure in the baby, and kidney problems.
Severe kidney disease: If your kidneys are not functioning properly, Perindopril may worsen kidney function. It is contraindicated in patients with severe kidney disease or those undergoing dialysis.
Hyperkalemia (high potassium levels): Perindopril can increase potassium levels in the blood, which may be dangerous for patients who already have high potassium levels.
Perindopril Drug Interactions
Perindopril can interact with other medications, which may increase the risk of side effects or reduce the effectiveness of treatment. Be sure to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements.
Medications that Interact with Perindopril
Nonsteroidal anti-inflammatory drugs (NSAIDs): Ibuprofen (Advil, Motrin), Naproxen (Aleve) – These medications can reduce the effectiveness of Perindopril and may increase the risk of kidney damage.
Diuretics: Furosemide (Lasix), Hydrochlorothiazide (Microzide) – These medications can increase the risk of low blood pressure and dehydration when taken with Perindopril.
Potassium supplements or potassium-sparing diuretics: Spironolactone (Aldactone), Eplerenone (Inspra) – These can raise potassium levels in the blood, which may lead to dangerous heart rhythms when combined with Perindopril.
Other blood pressure medications: Losartan (Cozaar), Valsartan (Diovan) – Taking these medications with Perindopril can cause your blood pressure to drop too low.
Diabetes medications: Insulin, Metformin (Glucophage) – Perindopril can enhance the effects of diabetes medications, leading to low blood sugar levels.
Perindopril in Pregnancy
Is it safe to take Perindopril when pregnant?
No, Perindopril is not considered safe during pregnancy. It is classified as a pregnancy category D medication, meaning there is evidence of risk to the developing baby. Taking Perindopril during the second and third trimesters can lead to serious complications, including birth defects, low blood pressure in the baby, and kidney problems. If you are pregnant or planning to become pregnant, it is crucial to consult your healthcare provider immediately to discuss safer alternatives.
Perindopril while Breastfeeding
Is it safe to take Perindopril while breastfeeding?
Perindopril is generally not recommended for use while breastfeeding. Although data is limited, ACE inhibitors can pass into breast milk and may affect the baby’s blood pressure or kidney function. If you are breastfeeding, it’s important to speak with your healthcare provider to explore safer treatment options.
Estimated Cost of Perindopril Medication
The cost of a 30-day supply of Perindopril without insurance can vary depending on the pharmacy and location. However, with a GoodRx coupon, the estimated cost is typically between $10 and $15 for a 30-day supply of Perindopril 4 mg or 8 mg tablets. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a coupon service like GoodRx for the most up-to-date pricing.
Possible Alternatives to Perindopril
If Perindopril is not suitable for you or if you are looking for alternative treatments, several options are available. It’s essential to discuss these alternatives with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore your options.
Hypertension (High Blood Pressure)
Alternative Medications: Losartan (Cozaar), Amlodipine (Norvasc), Hydrochlorothiazide (Microzide)
Lifestyle Changes: Reducing salt intake, engaging in regular physical activity, achieving a healthy weight, and managing stress
Heart Failure
Alternative Medications: Carvedilol (Coreg), Spironolactone (Aldactone), Valsartan (Diovan)
Lifestyle Changes: Limiting fluid intake, reducing sodium, and following a heart-healthy diet
Coronary Artery Disease
Alternative Medications: Atorvastatin (Lipitor), Clopidogrel (Plavix), Metoprolol (Lopressor)
Lifestyle Changes: Quitting smoking, adopting a heart-healthy diet, and increasing physical activity
Left Ventricular Dysfunction
Alternative Medications: Beta-blockers like Bisoprolol (Zebeta), ARBs like Losartan (Cozaar)
Lifestyle Changes: Managing blood pressure, reducing alcohol consumption, and maintaining a healthy weight
Diabetic Nephropathy
Alternative Medications: Losartan (Cozaar), Irbesartan (Avapro)
Lifestyle Changes: Controlling blood sugar levels, managing blood pressure, and following a kidney-friendly diet
Chronic Kidney Disease
Alternative Medications: ARBs like Valsartan (Diovan), Calcium channel blockers like Amlodipine (Norvasc)
Lifestyle Changes: Reducing protein intake, managing blood pressure, and avoiding NSAIDs
Stroke Prevention
Alternative Medications: Aspirin, Clopidogrel (Plavix), Statins like Atorvastatin (Lipitor)
Lifestyle Changes: Controlling blood pressure, quitting smoking, and maintaining a healthy diet
Myocardial Infarction (Heart Attack)
Alternative Medications: Beta-blockers like Metoprolol (Lopressor), Statins like Simvastatin (Zocor)
Lifestyle Changes: Quitting smoking, following a heart-healthy diet, and participating in cardiac rehabilitation
Atrial Fibrillation
Alternative Medications: Blood thinners like Warfarin (Coumadin), Beta-blockers like Atenolol (Tenormin)
Lifestyle Changes: Reducing alcohol and caffeine intake, managing stress, and maintaining a healthy weight
Peripheral Artery Disease
Alternative Medications: Cilostazol (Pletal), Aspirin, Clopidogrel (Plavix)
Lifestyle Changes: Quitting smoking, engaging in regular exercise, and managing cholesterol levels
Recent Updates on Perindopril Research
Recent studies have explored the long-term effects of ACE inhibitors like Perindopril in preventing cardiovascular events in high-risk patients. A 2022 study published in the Journal of Hypertension found that Perindopril, when combined with other antihypertensive medications, significantly reduced the risk of stroke and heart attack in patients with high blood pressure. Additionally, ongoing research is investigating the potential benefits of Perindopril in patients with chronic kidney disease, particularly in slowing the progression of kidney damage.
As more data becomes available, researchers are also examining the use of Perindopril alongside newer therapies to enhance its protective effects on the heart and kidneys. If you have questions about how these updates might impact your treatment, consider scheduling a telemedicine appointment with one of our providers to discuss the latest research and its relevance to your care plan.
