Palbociclib: Comprehensive Breast Cancer Treatment Overview

Summary of Key Points

Palbociclib is a prescription medication used to treat specific types of breast cancer, including hormone receptor-positive and HER2-negative breast cancers. It works by slowing the growth of cancer cells and is often prescribed alongside other treatments, such as hormone therapy. Always consult your healthcare provider before starting or adjusting your treatment. Our telemedicine providers are available to assist with any questions or concerns you may have regarding Palbociclib or your breast cancer treatment.

Names of Medication

US Brand Name: Ibrance (Palbociclib)

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.

Pharmacologic Category

Palbociclib belongs to a class of medications known as Cyclin-dependent kinase (CDK) 4/6 inhibitors.

Other medications in this category include:

1. Ribociclib (Kisqali)
2. Abemaciclib (Verzenio)

Palbociclib Dosage

Palbociclib is used to treat various types of breast cancer in adults. It is essential to follow your doctor’s instructions closely. Do not adjust your dose without consulting your healthcare provider. If you have concerns about your Palbociclib dosage or breast cancer treatment, you can also speak with one of our telemedicine providers.

Breast Cancer (Hormone Receptor-Positive, HER2-Negative, Advanced or Metastatic)

The recommended dosage of Palbociclib is 125 mg taken orally once daily for 21 consecutive days, followed by 7 days off treatment. This cycle repeats every 28 days. Palbociclib is typically taken in combination with hormone therapy, such as letrozole or fulvestrant.

ER-Positive, HER2-Negative Breast Cancer

The standard Palbociclib dose is 125 mg once daily for 21 days, followed by 7 days off. This cycle repeats every 28 days and is often combined with hormone therapy.

Triple-Negative Breast Cancer (Advanced or Metastatic)

Palbociclib is generally not used for triple-negative breast cancer unless under specific circumstances. Consult your doctor for personalized advice on your treatment options.

Recurrent or Stage IV Breast Cancer

The dosage remains 125 mg once daily for 21 days, followed by 7 days off. This cycle repeats every 28 days. The duration of treatment depends on how well you respond to Palbociclib.

Dosage Forms and Strengths

Palbociclib is available in the following forms and strengths:

1. Capsules: 75 mg, 100 mg, 125 mg
2. Tablets: 75 mg, 100 mg, 125 mg

Administration Instructions

Palbociclib should be taken with food to improve absorption. Swallow the capsules or tablets whole; do not crush, chew, or open them. If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not take two doses at once. Always follow your doctor’s instructions, and if you have any questions about how to take Palbociclib, our telemedicine providers are here to assist you.

Contraindications

A contraindication is a specific condition or situation where a medication should not be used because it may cause harm. It’s important to be aware of any contraindications before taking Palbociclib, as it could lead to serious side effects or complications.

Allergic Reaction to Palbociclib

If you have a known allergy to Palbociclib or any of its ingredients, you should not take this medication. An allergic reaction may cause symptoms such as rash, itching, swelling, or difficulty breathing.

Severe Liver Impairment

Palbociclib is processed by the liver. If your liver is not functioning properly, the medication may not be cleared effectively, which could lead to toxicity.

Pregnancy

Palbociclib can harm an unborn baby, so it is contraindicated during pregnancy (more details in the pregnancy section below).

Breastfeeding

Palbociclib may pass into breast milk, which could harm a nursing infant (more details in the breastfeeding section below).

Drug-to-Drug Interactions

Palbociclib can interact with other medications, increasing the risk of side effects or reducing the effectiveness of either drug. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs, supplements, and herbal products. Below are some common medications that may interact with Palbociclib:

1. Ketoconazole (Nizoral): This antifungal medication can increase Palbociclib levels in your blood, raising the risk of side effects.
2. Rifampin (Rifadin): This antibiotic can decrease Palbociclib’s effectiveness by lowering its levels in your blood.
3. Carbamazepine (Tegretol): This seizure medication can reduce Palbociclib’s effectiveness by speeding up its breakdown in the body.
4. St. John’s Wort: This herbal supplement can decrease Palbociclib’s effectiveness by increasing its metabolism.
5. Clarithromycin (Biaxin): This antibiotic can increase Palbociclib levels in the body, leading to a higher risk of side effects.

Palbociclib in Pregnancy

Is it Safe to Take Palbociclib During Pregnancy?

No, Palbociclib is not considered safe during pregnancy. It can harm an unborn baby, potentially leading to birth defects or miscarriage. If you are pregnant or planning to become pregnant, it is important to avoid taking Palbociclib. Women of childbearing age should use effective contraception while on Palbociclib and continue doing so for at least three weeks after the last dose. If you become pregnant while taking Palbociclib, contact your healthcare provider immediately to discuss your options and next steps.

Palbociclib While Breastfeeding

Is it Safe to Take Palbociclib While Breastfeeding?

No, Palbociclib is not recommended during breastfeeding. Although it is unclear whether Palbociclib passes into breast milk, the potential risk to a nursing infant is significant. Therefore, breastfeeding should be avoided during treatment and for at least three weeks after the last dose. If you are breastfeeding, consult your healthcare provider to explore alternative feeding options for your baby.

Estimated Cost of Palbociclib

The cost of a 30-day supply of Palbociclib without insurance typically ranges from $11,000 to $13,000 when using a GoodRx coupon. Prices may vary depending on the pharmacy and location. It is advisable to check with your pharmacy or use a coupon service like GoodRx to find the most affordable price available.

Possible Alternatives to Palbociclib

If Palbociclib is not suitable for you, there are other treatment options and lifestyle changes that may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss your alternatives.

Breast Cancer Treatment Alternatives

1. Breast cancer: Alternatives include chemotherapy, radiation therapy, and surgery. Hormonal therapies, such as tamoxifen or aromatase inhibitors, may also be considered depending on the specific type of breast cancer.
2. Hormone receptor-positive breast cancer: Hormonal therapies like letrozole (Femara) or anastrozole (Arimidex) may be used to block estrogen’s effects, which can fuel the growth of this cancer type.
3. Metastatic breast cancer: Treatment options may include targeted therapies such as trastuzumab (Herceptin) or chemotherapy. Lifestyle changes, including maintaining a healthy diet and regular exercise, can also improve quality of life.
4. ER-positive breast cancer: Hormonal therapies like fulvestrant (Faslodex) or tamoxifen may be used to block estrogen receptors and slow cancer growth.
5. HER2-negative breast cancer: Chemotherapy and hormonal therapies are commonly used. In some cases, surgery or radiation may also be recommended.
6. Triple-negative breast cancer: Chemotherapy is the primary treatment option, but immunotherapy with drugs like pembrolizumab (Keytruda) may also be considered.
7. Advanced breast cancer: Treatment may involve a combination of chemotherapy, targeted therapies, and hormonal therapies. Palliative care can also help manage symptoms and improve quality of life.
8. Recurrent breast cancer: Treatment depends on the location and extent of the recurrence. Options may include surgery, radiation, chemotherapy, or targeted therapies.
9. Stage IV breast cancer: Treatment focuses on controlling the spread of the disease and managing symptoms. This may include chemotherapy, targeted therapy, and palliative care.
10. Invasive breast cancer: Surgery, radiation, and chemotherapy are common treatments. Hormonal therapy may also be used if the cancer is hormone receptor-positive.

Recent Updates on Palbociclib Research

Recent studies continue to explore Palbociclib’s effectiveness when combined with other therapies. Research indicates that Palbociclib, when used alongside hormonal therapies like letrozole, can significantly extend progression-free survival in patients with hormone receptor-positive, HER2-negative breast cancer. Ongoing clinical trials are also investigating Palbociclib’s potential use in other cancers, including lung and prostate cancer. These studies aim to determine whether Palbociclib could benefit a broader range of cancers by targeting similar cell cycle pathways.

As research evolves, staying informed about new developments is crucial. If you have questions about how these updates may affect your treatment plan, consider scheduling a telemedicine appointment with one of our healthcare providers to discuss your options.

James Kingsley

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