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Oxaliplatin Chemotherapy: Uses, Dosage, and Side Effects
Oxaliplatin Chemotherapy: Key Points
Oxaliplatin is a chemotherapy drug commonly used to treat several types of cancer, including colorectal, gastric, and pancreatic cancers. It works by preventing cancer cells from growing and dividing. Typically, Oxaliplatin is administered through an intravenous (IV) infusion and is often combined with other medications. Like all chemotherapy treatments, it can cause side effects, so it’s important to discuss your treatment plan thoroughly with your healthcare provider.
Oxaliplatin: Brand and Generic Names
US Brand Name: Eloxatin (Oxaliplatin)
The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. In this case, Oxaliplatin is the generic name, and Eloxatin is the brand name.
Pharmacologic Category: Platinum-Based Chemotherapy
Oxaliplatin belongs to a class of drugs known as platinum-based chemotherapy agents, which also includes Cisplatin and Carboplatin. These medications work by disrupting the DNA of cancer cells, preventing them from growing and dividing.
Oxaliplatin Dosage for Various Cancers
Oxaliplatin is used to treat a range of cancers. The dosage and frequency of administration depend on the specific type of cancer being treated. Always consult your doctor before making any changes to your prescribed dose.
Oxaliplatin for Colorectal Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: Treatment typically lasts for 6 months, but your doctor will determine the exact length based on your response to therapy.
Oxaliplatin for Gastric Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: The duration of treatment varies depending on the stage of the cancer and how well you respond to therapy.
Oxaliplatin for Pancreatic Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: Your healthcare provider will determine the appropriate treatment duration based on your condition.
Oxaliplatin for Esophageal Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: The length of treatment depends on the stage of the cancer and your response to therapy.
Oxaliplatin for Ovarian Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: Your healthcare provider will determine the treatment duration based on your individual condition.
Oxaliplatin for Head and Neck Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: The duration of treatment depends on the stage of the cancer and your response to therapy.
Oxaliplatin for Neuroendocrine Tumors
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: Your healthcare provider will determine the appropriate treatment duration based on your condition.
Oxaliplatin for Biliary Tract Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: The length of treatment depends on the stage of the cancer and your response to therapy.
Oxaliplatin for Rectal Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: Treatment typically lasts for 6 months, but your doctor will determine the exact length based on your response to therapy.
Oxaliplatin for Small Intestine Cancer
Dosage: 85 mg/m² IV every 2 weeks, in combination with other chemotherapy drugs.
Duration: Your healthcare provider will determine the treatment duration based on your condition.
Oxaliplatin Dosage Forms and Strengths
Oxaliplatin is available in the following dosage forms:
- Injection, solution: 50 mg/10 mL (5 mg/mL)
- Injection, solution: 100 mg/20 mL (5 mg/mL)
Oxaliplatin Infusion Process: Administration Instructions
Oxaliplatin is administered as an intravenous (IV) infusion, typically in a hospital or clinic setting, over a period of about 2 hours. Treatments are usually scheduled every 2 weeks. It’s important to follow your doctor’s instructions carefully and report any side effects you experience during or after treatment. If you have any concerns, you can consult one of our healthcare providers through telemedicine.
Oxaliplatin Contraindications
A contraindication is a specific situation in which a drug should not be used because it may cause harm. There are several conditions that may make Oxaliplatin unsafe for certain individuals.
Allergy to Oxaliplatin or other platinum-based drugs: If you have had an allergic reaction to Oxaliplatin or other platinum-containing medications (such as Cisplatin or Carboplatin), you should not take Oxaliplatin. Allergic reactions can range from mild to severe, with symptoms including rash, itching, difficulty breathing, and swelling.
Severe kidney disease: Oxaliplatin is processed by the kidneys. If you have severe kidney disease, your body may not be able to eliminate the drug properly, which could lead to toxic levels in your system.
Peripheral neuropathy: If you already have nerve damage (neuropathy), Oxaliplatin may worsen this condition. It is known to cause nerve-related side effects, such as tingling, numbness, and pain in the hands and feet.
Pregnancy: Oxaliplatin can harm an unborn baby. If you are pregnant or planning to become pregnant, avoid this medication unless absolutely necessary. See the section below on Oxaliplatin in pregnancy for more details.
Oxaliplatin Drug Interactions
Oxaliplatin can interact with other medications, potentially increasing the risk of side effects or reducing the effectiveness of your treatment. Be sure to inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, and supplements.
Warfarin (Coumadin): Oxaliplatin may increase the risk of bleeding when taken with blood thinners like Warfarin. Your doctor may need to monitor your blood clotting levels more closely.
Aminoglycoside antibiotics (e.g., Gentamicin, Tobramycin): These antibiotics can increase the risk of kidney damage and hearing loss when used with Oxaliplatin.
Live vaccines: Receiving live vaccines (such as MMR or varicella) while on Oxaliplatin can increase your risk of infection, as chemotherapy may weaken your immune system.
NSAIDs (e.g., Ibuprofen, Naproxen): Nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of kidney damage when used with Oxaliplatin.
Oxaliplatin in Pregnancy
Is it safe to take Oxaliplatin when pregnant?
Oxaliplatin is generally not recommended during pregnancy. This chemotherapy drug can pose risks to an unborn baby, particularly during the first trimester when vital organs are forming. If you are pregnant or planning to become pregnant, it is essential to discuss your treatment options with your healthcare provider. In some cases, the potential benefits of using Oxaliplatin may outweigh the risks, but this decision should be made with careful consideration. If you are of childbearing age, your doctor may advise you to use effective contraception during treatment and for a period after your last dose of Oxaliplatin.
Oxaliplatin while Breastfeeding
Is it safe to take Oxaliplatin while breastfeeding?
Breastfeeding is not recommended while undergoing treatment with Oxaliplatin. It is unclear whether the drug passes into breast milk, but due to the potential for serious side effects in a nursing infant, it is advised to avoid breastfeeding during treatment. If you are currently breastfeeding or planning to breastfeed, consult your healthcare provider to explore alternative feeding options for your baby.
Estimated Cost of Oxaliplatin Chemotherapy
The cost of Oxaliplatin can vary depending on your location and the pharmacy you use. Without insurance, the estimated cost for a 30-day supply of Oxaliplatin using a GoodRX coupon ranges from approximately $1,000 to $2,500. Prices may fluctuate, so it’s a good idea to check with your pharmacy or use a coupon service like GoodRX to find the most affordable option.
Possible Alternatives to Oxaliplatin
If Oxaliplatin is not the right treatment for you, there may be alternative chemotherapy drugs or other treatment strategies that can help manage your condition. It’s important to discuss these options with your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to explore your options.
Colorectal Cancer
Alternatives to Oxaliplatin for colorectal cancer include other chemotherapy drugs such as irinotecan or fluorouracil (5-FU). Targeted therapies like bevacizumab (Avastin) or cetuximab (Erbitux) may also be considered. In some cases, surgery or radiation therapy may be appropriate.
Gastric Cancer
Other chemotherapy options for gastric cancer include cisplatin, capecitabine (Xeloda), or paclitaxel (Taxol). Targeted therapies like trastuzumab (Herceptin) may be used for certain types of gastric cancer.
Pancreatic Cancer
Alternatives for pancreatic cancer include gemcitabine (Gemzar) or nab-paclitaxel (Abraxane). Surgery and radiation therapy may also be part of the treatment plan.
Esophageal Cancer
Chemotherapy options for esophageal cancer include cisplatin, fluorouracil (5-FU), or paclitaxel (Taxol). Radiation therapy and surgery are also common treatments.
Ovarian Cancer
Alternatives for ovarian cancer include carboplatin, paclitaxel (Taxol), or bevacizumab (Avastin). Surgery is often a key part of treatment for ovarian cancer.
Head and Neck Cancer
Other chemotherapy options for head and neck cancer include cisplatin, fluorouracil (5-FU), or cetuximab (Erbitux). Radiation therapy and surgery may also be considered.
Neuroendocrine Tumors
Treatment options for neuroendocrine tumors may include everolimus (Afinitor), sunitinib (Sutent), or peptide receptor radionuclide therapy (PRRT). Surgery may also be an option.
Biliary Tract Cancer
Alternatives for biliary tract cancer include gemcitabine (Gemzar) or cisplatin. Surgery and radiation therapy may also be part of the treatment plan.
Rectal Cancer
Other chemotherapy options for rectal cancer include fluorouracil (5-FU) or capecitabine (Xeloda). Radiation therapy and surgery are also common treatments for rectal cancer.
Small Intestine Cancer
Treatment options for small intestine cancer may include fluorouracil (5-FU), capecitabine (Xeloda), or surgery. Radiation therapy may also be considered.
Recent Updates on Oxaliplatin Research
Recent studies on Oxaliplatin have focused on improving its effectiveness and minimizing its side effects. One area of research involves developing combination therapies that pair Oxaliplatin with other drugs to enhance its cancer-fighting abilities. For example, researchers are exploring the use of immunotherapy drugs alongside Oxaliplatin to strengthen the immune system’s ability to target cancer cells.
Another area of research is aimed at reducing the nerve-related side effects (neuropathy) associated with Oxaliplatin. Studies are investigating the use of medications like gabapentin or supplements such as vitamin E to help prevent or manage neuropathy in patients receiving Oxaliplatin.
Ongoing clinical trials are also examining the use of Oxaliplatin in combination with newer targeted therapies and personalized medicine approaches. These trials aim to identify which patients are most likely to benefit from Oxaliplatin based on their genetic profile or the specific characteristics of their cancer.
If you are interested in learning more about the latest research or participating in a clinical trial, speak with your healthcare provider. You can also schedule a telemedicine appointment with one of our providers to discuss your treatment options and any new developments in cancer care.
