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Nystatin: Antifungal Uses, Dosage, and Side Effects Explained
Key Points About Nystatin
Nystatin is an antifungal medication used to treat various fungal infections, including oral thrush, vaginal yeast infections, and skin infections caused by Candida. It works by inhibiting fungal growth. Nystatin is available in several forms, such as oral suspension, tablets, and topical creams. Always consult your healthcare provider before starting or adjusting your dose. You can schedule a telemedicine appointment with one of our providers for personalized advice.
Nystatin Medication Names
US Brand Name: Mycostatin, Bio-Statin
Generic Name: Nystatin
The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.
Pharmacologic Category of Nystatin
Antifungal, Polyene
Nystatin Dosage and Uses
Nystatin is prescribed to treat a variety of fungal infections. The Nystatin dosage depends on the type of infection and the form of the medication. Always follow your healthcare provider’s instructions and consult them before making any changes to your dose. You can also speak to one of our telemedicine providers for guidance.
Nystatin for Oral Thrush (Candidiasis)
Oral Suspension: 400,000 to 600,000 units, 4 times daily. Swish the liquid in your mouth and hold it for as long as possible before swallowing. Treatment typically lasts 7 to 14 days or until symptoms resolve.
Nystatin for Vaginal Yeast Infection
Vaginal Cream: 100,000 units applied once daily for 14 days.
Nystatin for Skin Infections (Cutaneous Candidiasis)
Topical Cream or Ointment: Apply to the affected area 2 to 3 times daily until the infection clears.
Nystatin for Esophageal Candidiasis
Oral Suspension: 500,000 units 4 times daily. Treatment duration is typically 14 to 21 days.
Nystatin for Diaper Rash (Candidiasis)
Topical Cream or Ointment: Apply to the affected area 2 to 3 times daily until the rash clears.
Nystatin for Fungal Skin Infections
Topical Cream or Ointment: Apply to the affected area 2 to 3 times daily until the infection clears.
Nystatin for Intertrigo (Candidiasis in Skin Folds)
Topical Cream or Ointment: Apply to the affected area 2 to 3 times daily until the infection clears.
Nystatin for Fungal Nail Infection (Onychomycosis)
Topical Cream or Ointment: Apply to the affected area 2 to 3 times daily. Treatment may last several months due to the slow growth of nails.
Nystatin for Systemic Candidiasis
Oral Tablets: 500,000 units 3 to 4 times daily. The duration of treatment depends on the severity of the infection and your healthcare provider’s recommendation.
Nystatin Dosage Forms and Strengths
Oral Suspension: 100,000 units/mL
Tablets: 500,000 units
Topical Cream: 100,000 units/gram
Topical Ointment: 100,000 units/gram
Vaginal Cream: 100,000 units/gram
How to Use Nystatin: Administration Instructions
Nystatin should be used exactly as prescribed by your healthcare provider. For Nystatin oral suspension, swish the liquid in your mouth for as long as possible before swallowing. For topical forms, apply a thin layer to the affected area and gently rub it in. For vaginal cream, use the applicator provided to insert the medication. Always wash your hands before and after applying the medication. If you miss a dose, take it as soon as you remember, but do not double up on doses.
Contraindications for Nystatin
A contraindication is a specific situation where a medication should not be used because it may be harmful. For Nystatin, certain conditions or factors make it unsafe to take. Below are the main contraindications for Nystatin:
- Allergy to Nystatin or its ingredients: If you have a known allergy to Nystatin or any of its inactive ingredients, taking this medication could trigger a severe allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, or throat.
- Severe liver disease: Although Nystatin is not absorbed into the bloodstream in significant amounts when used topically or orally, patients with severe liver disease should still exercise caution. Liver disease may affect how the body processes medications, so it’s important to discuss your condition with a healthcare provider.
- Pregnancy (in certain forms): While topical and oral forms of Nystatin are generally considered safe, certain forms or dosages may not be recommended during pregnancy. Always consult your healthcare provider before starting any medication during pregnancy.
Drug Interactions with Nystatin
Nystatin is generally well-tolerated and has few known drug interactions. However, it’s still important to inform your healthcare provider about all the medications you are taking. Below are some medications that may interact with Nystatin:
- Clotrimazole (Lotrimin): Using other antifungal medications like Clotrimazole alongside Nystatin may reduce the effectiveness of either drug.
- Warfarin (Coumadin): Although rare, there is a potential for interaction with blood thinners like Warfarin, which could increase the risk of bleeding.
- Oral contraceptives (birth control pills): Some antifungal medications can reduce the effectiveness of birth control pills. While Nystatin is less likely to cause this, it’s important to discuss this with your healthcare provider.
Nystatin in Pregnancy
Is it safe to take Nystatin when pregnant?
Nystatin is generally considered safe to use during pregnancy, especially in topical or oral forms, as it is minimally absorbed into the bloodstream. However, it’s always important to consult your healthcare provider before starting any new medication while pregnant. If you are dealing with a fungal infection during pregnancy, one of our telemedicine providers can help determine whether Nystatin is the right treatment for you.
Nystatin while Breastfeeding
Is it safe to take Nystatin while breastfeeding?
Nystatin is typically regarded as safe to use while breastfeeding, as it is not absorbed in significant amounts into the bloodstream and is unlikely to pass into breast milk. Nevertheless, it’s always a good idea to discuss any medications with your healthcare provider, particularly when breastfeeding. If you have any concerns, consult one of our telemedicine providers for personalized guidance.
Estimated Cost of Nystatin Medication
The cost of a 30-day supply of Nystatin without insurance can vary depending on the form (oral suspension, cream, or powder). With a GoodRx coupon, the price for a 30-day supply of Nystatin oral suspension typically ranges from $15 to $30. Prices may differ based on your location and pharmacy, so it’s always a good idea to compare options to find the best deal.
Possible Alternatives to Nystatin
If Nystatin is not the most suitable antifungal medication for you, there are alternative treatments and lifestyle adjustments that may help manage fungal infections. Always discuss these alternatives with your healthcare provider before making any changes to your treatment plan. You can also consult one of our telemedicine providers for advice on these options.
Alternative Treatments for Common Fungal Infections
- Candidiasis: Alternatives include antifungal medications such as Fluconazole (Diflucan) or Clotrimazole (Lotrimin). Maintaining good hygiene and keeping affected areas dry can help prevent recurrence.
- Oral thrush: Fluconazole (Diflucan) or Clotrimazole (Mycelex) lozenges may be used as alternatives. Rinsing your mouth with saltwater and practicing good oral hygiene can help manage symptoms.
- Vaginal yeast infection: Over-the-counter antifungal creams like Miconazole (Monistat) or oral Fluconazole (Diflucan) are common alternatives. Wearing loose-fitting clothing and avoiding scented hygiene products can help prevent infections.
- Cutaneous candidiasis: Topical antifungal creams such as Clotrimazole (Lotrimin) or Miconazole (Monistat) can be effective. Keeping the skin clean and dry is essential for preventing fungal growth.
- Esophageal candidiasis: Oral Fluconazole (Diflucan) is often used as an alternative. Maintaining good oral hygiene and managing underlying conditions like diabetes can help reduce the risk of recurrence.
- Diaper rash: Zinc oxide creams or petroleum jelly can help soothe the skin. Keeping the diaper area clean and dry is crucial for preventing further irritation.
- Fungal skin infections: Topical antifungal creams like Terbinafine (Lamisil) or Clotrimazole (Lotrimin) are effective alternatives. Avoiding tight clothing and keeping the skin dry can help prevent fungal infections.
- Intertrigo: Keeping skin folds dry and using barrier creams can help manage symptoms. Antifungal creams like Clotrimazole (Lotrimin) may also be used.
- Onychomycosis (fungal nail infection): Oral antifungal medications such as Terbinafine (Lamisil) or topical treatments like Ciclopirox (Penlac) can be used. Keeping nails trimmed and dry can help prevent fungal infections.
- Systemic candidiasis: Oral or intravenous antifungal medications like Fluconazole (Diflucan) or Amphotericin B are typically used. Managing underlying health conditions such as diabetes or immunosuppression is also important.
Recent Updates on Nystatin Research
Recent research on Nystatin has explored its potential beyond treating fungal infections. Studies are investigating its anti-inflammatory properties and its ability to disrupt biofilms—protective layers formed by bacteria and fungi that make infections more difficult to treat. Researchers are also examining the potential for Nystatin to be used in combination with other antifungal medications to improve outcomes for resistant fungal infections. While these studies are still in the early stages, they offer promising insights into future uses of Nystatin. As always, consult your healthcare provider for the most up-to-date information on your treatment options.
